2',4'-di-O-acetyldesmycosin | 56858-50-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2',4'-di-O-acetyldesmycosin
• 英文别名: [(2R,3S,4S,5R,6R)-5-acetyloxy-4-(dimethylamino)-6-[[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-2-methyloxan-3-yl] acetate
• CAS: 56858-50-5
• 化学式: C₄₃H₆₉NO₁₆
• 分子量: 856.018
• InChiKey: LBFIXWMSXUDJQE-FRGKLBKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  60.0
• 可旋转键数：
  13.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  212.12
• 氢给体数：
  2.0
• 氢受体数：
  17.0

反应信息

• 作为反应物：
  描述：

  2',4'-di-O-acetyldesmycosin 生成 2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4S,5S,6R)-3,5-diacetyloxy-4-(dimethylamino)-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetic acid
  参考文献：
  名称：

  VATANABEH, XIDEHYUKI;OGAMI, YUDZI;OXARA, TAKUMI;FUDZIVARA, TATSURO;FUKUGA+

  摘要：

  DOI：
• 作为产物：
  描述：

  泰乐菌素B 生成 2',4'-di-O-acetyldesmycosin
  参考文献：
  名称：

  VATANABEH, XIDEHYUKI;OGAMI, YUDZI;OXARA, TAKUMI;FUDZIVARA, TATSURO;FUKUGA+

  摘要：

  DOI：

文献信息

• Peptide derivatives of tylosin-related macrolides
  作者：G. A. Korshunova、N. V. Sumbatyan、N. V. Fedorova、I. V. Kuznetsova、A. V. Shishkina、A. A. Bogdanov

  DOI：10.1134/s1068162007020033

  日期：2007.3

  Approaches to the synthesis of model compounds based on the tylosin-related macrolides desmycosin and O=mycaminosyltylonolide were developed to study the conformation and topography of the nascent peptide chain in the ribosome tunnel using specially designed peptide derivatives of macrolide antibiotics. A method for selective bromoacetylation of desmycosin at the hydroxyl group of mycinose was developed

  开发了基于泰乐菌素相关的大环内酯类去霉素和 O=mycaminosyltylonolide 的模型化合物的合成方法，以使用专门设计的大环内酯类抗生素的肽衍生物研究核糖体隧道中新生肽链的构象和形貌。开发了一种在mycinose 羟基上选择性溴乙酰化脱粘菌素的方法，该方法涉及mycaminose 的初步乙酰化。抗生素的 4″-溴乙酰基衍生物与二肽 Boc-Ala-Ala-OH 和六肽 MeOTr-Gly-Pro-Gly-Pro-Gly-Pro-OH 的铯盐反应生成相应的肽衍生物去霉菌素。受保护的肽 Boc-Ala-Ala-OH、Boc-Ala-Ala-Phe-OH 和 Boc-Gly-Pro-Gly-Pro-Gly-Pro-OH 与 O-mycaminosyltylonolide 的 C23-羟基缩合。
• 3,6-BRIDGED TYLOSIN DERIVATIVES
  申请人：Qiu Yao-Ling

  公开号：US20080039406A1

  公开（公告）日：2008-02-14

  The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

  本发明公开了化合物I的结构，或其药学上可接受的盐、酯或前药：这些化合物具有抗菌性能。本发明还涉及包含上述化合物的药物组合物，用于给需要抗生素治疗的受试者进行治疗。本发明还涉及通过给受试者施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。本发明还包括制备本发明化合物的方法。
• FUJIWARA, TATSURO;WATANABE, HIDEYUKI;KOGAMI, YUJI;SHIRITANI, YOSHINORI;SA+, J. ANTIBIOTICS, 42,(1989) N, C. 903-912
  作者：FUJIWARA, TATSURO、WATANABE, HIDEYUKI、KOGAMI, YUJI、SHIRITANI, YOSHINORI、SA+

  DOI：——

  日期：——