1-[2-Hydroxy-4-[3-(4-methoxyphenoxy)propoxy]phenyl]ethanone | 63360-03-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-Hydroxy-4-[3-(4-methoxyphenoxy)propoxy]phenyl]ethanone
• 英文别名: 1-[2-hydroxy-4-[3-(4-methoxyphenoxy)propoxy]phenyl]ethanone
• CAS: 63360-03-2
• 化学式: C₁₈H₂₀O₅
• 分子量: 316.354
• InChiKey: JSVULXSFTDECCB-UHFFFAOYSA-N

物化性质

• 沸点：
  493.2±35.0 °C(Predicted)
• 密度：
  1.176±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,4-二羟基苯乙酮 、 1-(3-溴丙氧基)-4-甲氧基苯 在 potassium carbonate 作用下， 生成 1-[2-Hydroxy-4-[3-(4-methoxyphenoxy)propoxy]phenyl]ethanone
  参考文献：
  名称：

  Aryloxyalkyloxy- and aralkyloxy-4-hydroxy-3-nitrocoumarins which inhibit histamine release in the rat and also antagonize the effects of a slow reacting substance of anaphylaxis

  摘要：

  The syntheses and structure--activity relationships of a number of 4-hydroxy-3-nitrocoumarins, which are both antagonists of a slow reacting substance of anaphylaxis and potent inhibitors of antigen-induced histamine release in the rat, are described. Most active among these are 7-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy(-2-hydroxypropoxy] derivatives having hydrogen or lower alkyl substituents at the C-8 position of the coumarin ring, 168, 171, 173, and 174.

  DOI：

  10.1021/jm00188a007

文献信息

• Aryloxyalkyloxy- and aralkyloxy-4-hydroxy-3-nitrocoumarins which inhibit histamine release in the rat and also antagonize the effects of a slow reacting substance of anaphylaxis
  作者：Derek R. Buckle、D. James Outred、Janet W. Ross、Harry Smith、Raymond J. Smith、Barbara A. Spicer、Brian C. Gasson

  DOI：10.1021/jm00188a007

  日期：1979.2

  The syntheses and structure--activity relationships of a number of 4-hydroxy-3-nitrocoumarins, which are both antagonists of a slow reacting substance of anaphylaxis and potent inhibitors of antigen-induced histamine release in the rat, are described. Most active among these are 7-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy(-2-hydroxypropoxy] derivatives having hydrogen or lower alkyl substituents at the C-8 position of the coumarin ring, 168, 171, 173, and 174.