2-hydroxy-quinoline-3,4-dicarboxylic acid | 103646-21-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-hydroxy-quinoline-3,4-dicarboxylic acid
• 英文别名: 2-Hydroxy-chinolin-3,4-dicarbonsaeure；2-hydroxy-3,4-quinolinedicarboxylic acid；2-Hydroxy-chinolin-dicarbonsaeure-(3,4)；2-Oxo-1,2-dihydroquinoline-3,4-dicarboxylic acid；2-oxo-1H-quinoline-3,4-dicarboxylic acid
• CAS: 103646-21-5
• 化学式: C₁₁H₇NO₅
• mdl: MFCD03043403
• 分子量: 233.18
• InChiKey: VTPQFYZNFAEAQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-hydroxy-quinoline-3,4-dicarboxylic acid 、 三氯氧磷 在 ice water 作用下， 以 氯仿 为溶剂， 反应 2.0h， 以to afford Furo[3,4-c]quinoline-1,3,4(5H)-trione as a yellow solid的产率得到Furo[3,4-c]quinoline-1,3,4(5H)-trione
  参考文献：
  名称：

  Certain pyrroloquinolinones; a new class of gaba brain receptor ligands

  摘要：

  本发明涵盖了式(I)的化合物及其药学上可接受的非毒性盐，其中X和Y相同或不同，分别表示氧或H.sub.2，但不得同时为H.sub.2；W表示苯基、噻吩基或吡啶基，每个基团可以是未取代的或单取代或双取代的有机或无机取代基；R.sub.1、R.sub.2、R.sub.3和R.sub.4是代表有机和无机取代基的变量。这些化合物是高度选择性的GABAa脑受体激动剂、拮抗剂或反向激动剂，或其前药，可用于诊断和治疗焦虑、睡眠和癫痫过量的苯二氮卓类药物以及增强记忆。

  公开号：

  US05604235A1
• 作为产物：
  描述：

  cyano-(2-oxo-indolin-3-yliden)-acetic acid methyl ester 在 盐酸 、 溶剂黄146 作用下， 生成 2-hydroxy-quinoline-3,4-dicarboxylic acid
  参考文献：
  名称：

  Fiesselmann; Ehmann, Chemische Berichte, 1958, vol. 91, p. 1706,1712

  摘要：

  DOI：

文献信息

• Process for the preparation of 2-hydroxypyridine or quinoline compounds
  申请人：Allied-Signal Inc.

  公开号：US04968803A1

  公开（公告）日：1990-11-06

  The present invention relates to a process for the preparation of hydroxypyridine based compounds. The process comprises the step of: in water, reacting a pyridine based compound with the proviso that the second position on the nitrogen ring is unsubstituted and the fourth position in the nitrogen ring is not substituted with halogen, with elemental fluorine at a temperature of about -25.degree. to about +30.degree. C. for a time sufficient to form a 2-hydroxypyridine based compound. The resulting 2-hydroxypyridine or quinoline carboxylic acids and esters are useful as herbicide and pharmaceutical intermediates.

  本发明涉及一种制备羟基吡啶基化合物的方法。该方法包括以下步骤：在水中，将一种吡啶基化合物与元素氟在温度约为-25度至+30度之间反应，其中氮环上的第二位置未取代，氮环中的第四位置未用卤素取代，反应时间足以形成一种2-羟基吡啶基化合物。所得的2-羟基吡啶或喹啉羧酸和酯可用作除草剂和药物中间体。
• COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS
  申请人：Chodorowski-Kimmes Sandrine

  公开号：US20100239509A1

  公开（公告）日：2010-09-23

  The present patent application relates to a cosmetic or dermatological composition comprising, in a cosmetically or dermatologically acceptable medium, a polymer comprising: (a) a polymer backbone that may be obtained by reaction: of a polyol comprising 3 to 6 hydroxyl groups; of a monocarboxylic acid containing 6 to 32 carbon atoms; of a polycarboxylic acid comprising at least two carboxylic groups COOH, and/or of a cyclic anhydride such as a polycarboxylic acid and/or of a lactone comprising at least one carboxylic group COOH; and (b) at least one junction group linked to the said polymer backbone and capable of establishing H bonds with one or more partner junction groups, each pairing of a junction group involving at least three H (hydrogen) bonds. The patent application also concerns a cosmetic treatment process using the said composition.

  本专利申请涉及一种化妆品或皮肤科学组合物，包括在化妆品或皮肤科学上可接受的介质中，包含以下聚合物的组合物：(a) 由以下反应得到的聚合物骨架：含有3至6个羟基的多元醇；含有6至32个碳原子的一元羧酸；至少含有两个羧基COOH的多元羧酸，和/或类似多元羧酸的环酐和/或至少含有一个羧基COOH的内酯；以及(b) 至少一个连接到所述聚合物骨架的连接基团，并能够与一个或多个配对连接基团建立H键，每个连接基团的配对涉及至少三个H（氢）键。该专利申请还涉及使用所述组合物的化妆品处理过程。
• COMPOSITION COMPRISING A POLYCONDENSATE, METHOD OF TREATMENT, POLYCONDENSATE, AND METHOD OF PREPARATION
  申请人：GIUSTINIANI Pascal

  公开号：US20090028807A1

  公开（公告）日：2009-01-29

  The present application relates to a cosmetic or pharmaceutical, in particular lipstick, composition comprising a polycondensate The application also relates to a method of cosmetic treatment using the composition, the polycondensate thus defined and a method of preparing the polycondensate.

  本申请涉及一种化妆品或药用品，特别是口红，包括聚缩酸酯的组合物。该申请还涉及一种使用该组合物进行化妆处理的方法，所述聚缩酸酯的定义以及一种制备聚缩酸酯的方法。
• COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT
  申请人：Malle Gerard

  公开号：US20100272660A1

  公开（公告）日：2010-10-28

  The present application relates to a cosmetic or pharmaceutical composition comprising a polycondensate capable of being obtained by the reaction of the following monomers alone: of 10 to 30% by weight, relative to the total weight of the polycondensate, of one or more polyols comprising 3 to 6 hydroxyl groups; of 30 to 80% by weight, relative to the total weight of the polycondensate, of one or more linear, branched and/or cyclic, saturated or unsaturated, non-aromatic monocarboxylic acids comprising 6 to 32 carbon atoms; of 1 to 40% by weight, relative to the total weight of the polycondensate, of one or more polycarboxylic acids and/or cyclic anhydrides of such a polycarboxylic acid and/or lactones comprising at least one COOH group; and optionally of 0.1 to 15% by weight, relative to the total weight of the polycondensate, of one or more silicones having a hydroxyl and/or carboxyl functional group. The application also relates to a method of cosmetic treatment using the said composition, and the polycondensate thus defined.

  本申请涉及一种化妆品或药用组合物，包括由以下单体反应而得的聚缩酸酯：相对于聚缩酸酯的总重量，占10至30%的一种或多种含有3至6个羟基的多元醇；占30至80%的一种或多种线性、支链和/或环状、饱和或不饱和、非芳香族的单羧酸，含有6至32个碳原子；占聚缩酸酯总重量的1至40%的一种或多种多羧酸和/或多羧酸的环状酐和/或含有至少一个COOH基团的内酯；以及可选地占聚缩酸酯总重量的0.1至15%的一种或多种硅氧烷，具有羟基和/或羧基官能团。该申请还涉及使用所述组合物进行化妆处理的方法，以及如此定义的聚缩酸酯。
• Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
  申请人：Neurogen Corporation

  公开号：US05243049A1

  公开（公告）日：1993-09-07

  This invention encompasses compounds of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein X and Y are the same or different and represent oxygen or H.sub.2 with the proviso that not both X and Y are H.sub.2 ; W represents phenyl, thienyl, or pyridyl, each of which may be unsubstituted or momo or disubstituted with organic or inorganic substituents; and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are variables representing organic and inorganic substituents. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.

  本发明涵盖如下式的化合物：##STR1##及其药学上可接受的非毒性盐，其中X和Y相同或不同，分别代表氧或H.sub.2，但X和Y不同时为H.sub.2；W代表苯基、噻吩基或吡啶基，每种基团可以是未取代的或仅有机或无机取代基团或二取代基团；R.sub.1、R.sub.2、R.sub.3和R.sub.4是代表有机和无机取代基团的变量。这些化合物是高度选择性的GABAa脑受体的激动剂、拮抗剂或反向激动剂或其前药物，可用于诊断和治疗焦虑、睡眠和癫痫障碍、苯二氮平类药物过量以及增强记忆。