N-(4-amino-2-methylquinolin-6-yl)-2-[(4-fluorophenoxy)methyl]benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(4-amino-2-methylquinolin-6-yl)-2-[(4-fluorophenoxy)methyl]benzamide
• 化学式: C₂₄H₂₀FN₃O₂
• 分子量: 401.44
• InChiKey: MMDYFXPOSJWRFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  77.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-甲基-4-氨基-六硝基癸啉 在 吡啶 、 氢氧化钾 、 aluminum nickel 作用下， 以 甲醇 、 水 为溶剂， 反应 5.0h， 生成 N-(4-amino-2-methylquinolin-6-yl)-2-[(4-fluorophenoxy)methyl]benzamide
  参考文献：
  名称：

  A new synthetic approach of N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide (JTC-801) and its analogues and their pharmacological evaluation as nociceptin receptor (NOP) antagonists

  摘要：

  A series of 4-amino-2-methylquinoline and 4-aminoquinazoline derivatives, including the reference NOP antagonist JTC-801, were synthesized by an alternative pathway and their in vitro pharmacological properties were investigated. 3-Substitution of the quinoline ring resulted very critical for affinity. So 3-methyl derivative 4j showed a similar potency compared with the reference 4h while bulky lipophilic or electron withdrawing groups in the same position strongly decreased affinity. Structural and conformational requirements for affinity were outlined by NOE NMR and computational methods and suggestions for a pharmacophore model design were provided. (C) 2004 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.09.009