| 1386972-47-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1386972-47-9
• 化学式: C₄₈H₅₂N₄O₈Si
• 分子量: 841.048
• InChiKey: HRZQMFCUPJMEAQ-SXRASJEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.04
• 重原子数：
  61.0
• 可旋转键数：
  16.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  150.31
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  在 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以99%的产率得到2'-aminoethyl 3-O-acetyl-2-azido-4-O-benzyl-6-O-(tert-butyldiphenylsilyl)-2-deoxy-β-D-glucopyranoside
  参考文献：
  名称：

  Solid-Phase Synthesis of 2-Aminoethyl Glucosamine Sulfoforms

  摘要：

  Mono- and disaccharides of sulfonated glucosamines (GlcN sulfoforms) conjugated to 2-aminoethyl linkers were generated by solid-phase synthesis. Orthogonally protected intermediates were tethered onto tritylated polystyrene resin beads, subjected to a modular sequence of deprotection and sulfonation steps, then cleaved from solid support without degradation of N- or O-sulfate esters using solvolytic conditions, and finally purified by reverse-phase HPLC to afford the title compounds.

  DOI：

  10.1080/07328303.2012.658274
• 作为产物：
  描述：

  (2S,3R,4R,5S,6R)-3-azido-5-(benzyloxy)-6-(hydroxymethyl)-2-(p-tolylthio)tetrahydro-2H-pyran-4-yl acetate 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 19.0h， 生成
  参考文献：
  名称：

  Solid-Phase Synthesis of 2-Aminoethyl Glucosamine Sulfoforms

  摘要：

  Mono- and disaccharides of sulfonated glucosamines (GlcN sulfoforms) conjugated to 2-aminoethyl linkers were generated by solid-phase synthesis. Orthogonally protected intermediates were tethered onto tritylated polystyrene resin beads, subjected to a modular sequence of deprotection and sulfonation steps, then cleaved from solid support without degradation of N- or O-sulfate esters using solvolytic conditions, and finally purified by reverse-phase HPLC to afford the title compounds.

  DOI：

  10.1080/07328303.2012.658274