Acetic acid (2R,3S,4R,5R,6S)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-[4-(6-amino-hexanoylamino)-2-difluoromethyl-phenoxy]-tetrahydro-pyran-4-yl ester 在
水 、
三乙胺 作用下,
以
乙醇 、
N,N-二甲基甲酰胺 为溶剂,
生成 6-[3-[[3-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethylamino]-3-oxopropyl]disulfanyl]propanoylamino]-N-[4-[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(difluoromethyl)phenyl]hexanamide