| 861401-13-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 861401-13-0
• 化学式: C₄₂H₇₆N₆O₁₈
• 分子量: 953.095
• InChiKey: HOGNSGQZQIVZLX-RIFODQPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.14
• 重原子数：
  66.0
• 可旋转键数：
  14.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  346.51
• 氢给体数：
  11.0
• 氢受体数：
  19.0

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal 氢气 、 三乙胺 作用下， 以 1,4-二氧六环 、 甲醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and antibacterial activity of 5-deoxy-5-episubstituted arbekacin derivatives

  摘要：

  5-Deoxy-5-episubstituted arbekacin derivatives have been designed and efficiently synthesized. The synthetic compounds showed potent antibacterial activity against both Staphylococcus aureus, including methicillin-resistant S. aureus, and Pseudomonas aeruginosa. In particular, these derivatives were superior to arbekacin against MRSA strains expressing the bifunctional aminoglycoside-modifying enzyme AAQ6')-APH(2"). The antibacterial activity of the 5-deoxy-5-episubstituted arbekacin derivatives against Pseudomonas aeruginosa was markedly influenced by the efflux system of MexXY/OprM. The 6'-N-methyl derivative of the 5-epi arbekacin was effective against Pseudomonas aeruginosa expressing the aminoglycoside-modifying enzyme AAC(6'). (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.065
• 作为产物：
  描述：

  6'-N-benzyloxycarbonyl-arbekacin 在 palladium on activated charcoal 氢气 、 三乙胺 作用下， 以 1,4-二氧六环 、 甲醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and antibacterial activity of 5-deoxy-5-episubstituted arbekacin derivatives

  摘要：

  5-Deoxy-5-episubstituted arbekacin derivatives have been designed and efficiently synthesized. The synthetic compounds showed potent antibacterial activity against both Staphylococcus aureus, including methicillin-resistant S. aureus, and Pseudomonas aeruginosa. In particular, these derivatives were superior to arbekacin against MRSA strains expressing the bifunctional aminoglycoside-modifying enzyme AAQ6')-APH(2"). The antibacterial activity of the 5-deoxy-5-episubstituted arbekacin derivatives against Pseudomonas aeruginosa was markedly influenced by the efflux system of MexXY/OprM. The 6'-N-methyl derivative of the 5-epi arbekacin was effective against Pseudomonas aeruginosa expressing the aminoglycoside-modifying enzyme AAC(6'). (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.065

文献信息

• EP1710248
  申请人：——

  公开号：——

  公开（公告）日：——