(R)-sodium 2,2-dimethyl-1,3-dioxolane-4-carboxylate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-sodium 2,2-dimethyl-1,3-dioxolane-4-carboxylate
• 英文别名: sodium 2,3-O-isopropylidene-D-glycerate；sodium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate；sodium;(4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate
• 化学式: C₆H₉O₄*Na
• 分子量: 168.125
• InChiKey: IRJQADBKWNAHDO-PGMHMLKASA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.11
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  58.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  二甲羟胺盐酸盐 、 (R)-sodium 2,2-dimethyl-1,3-dioxolane-4-carboxylate 在 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以57%的产率得到(2R)-2,3-O-isopropylidene-N-methoxy-N-methylpropanamide
  参考文献：
  名称：

  (S)-(-)-伞形内酯和相关α,β-丁烯内酯的合成

  摘要：

  描述了从市售 D-甘露醇开始合成 α,β-丁烯内酯构件的不对称路线的开发。将设计的路线应用于抗病毒天然产物伞形内酯的 (S)-(-)-对映异构体的合成，以及其他合成有用的内酯结构的构建。

  DOI：

  10.1055/s-0029-1219181
• 作为产物：
  描述：

  双丙酮-D-甘露糖醇 在 ruthenium trichloride 、 sodium hydroxide 、 sodium hypochlorite 作用下， 反应 0.5h， 以95%的产率得到(R)-sodium 2,2-dimethyl-1,3-dioxolane-4-carboxylate
  参考文献：
  名称：

  A new convenient method for the synthesis of chiral C3-synthons

  摘要：

  Routes are described for the facile preparation of protected optically pure D- and L-glyceric acid (1a,b; 2a,b) starting from D-mannitol, D-isoascorbic acid and L-ascorbic acid. The key step is a ruthenium catalyzed oxidative cleavage of the vicinal diols 4a,b or the alpha-hydroxy acids 7a,b; 10a,b.

  DOI：

  10.1016/s0957-4166(00)82119-9

文献信息

• Process for the separation of R and S-2,2-R.sub.1,R.sub.2
  申请人：Shell Internationale Research Maatschappij B.V.

  公开号：US05164519A1

  公开（公告）日：1992-11-17

  A process is disclosed for preparing a 2,2-R.sub.1, R.sub.2 -1,3-dioxolane-4-carboxylic acid or salt thereof rich in either the R or S enantiomer which process comprises a) preparing a solution which contains a non-racemic mixture of R and S enantiomer of a carboxylate of the formula ##STR1## and M.sup.n+ ions, wherein R.sub.1 and R.sub.2 are each, independently, H or an unsubstituted or substituted alkyl group, or R.sub.1 and R.sub.2, together with the carbon atom to which they are attached, form an unsubstituted or substituted carbocyclic ring, and M is an alkali metal, an alkaline earth metal, a group IIb metal, boron, or an ammonium, di- or tri-alkanolammonium ion having 2 or 3 carbon atoms or a tetra C.sub.1 -C.sub.16 alkyl ammonium ion, and n is the valency of M; b) reducing the solubility of the M.sup.n+ salt of compound (I); and c) separating the resulting crystals from the mother liquor.

  公开了一种制备2,2-R.sub.1，R.sub.2-1,3-二氧兰-4-羧酸或其盐的过程，其中该过程包括：a）制备含有式的羧酸盐的R和S对映体的非外消旋混合物及M.sup.n+离子的溶液：##STR1## 其中R.sub.1和R.sub.2各自独立地为H或未取代或取代的烷基，或R.sub.1和R.sub.2与它们所连接的碳原子一起形成未取代或取代的碳环；M是碱金属，碱土金属，IIb族金属，硼或具有2或3个碳原子的铵，二元或三元醇铵离子或四个C.sub.1-C.sub.16烷基铵离子，n是M的价；b）降低化合物（I）的M.sup.n+盐的溶解度；c）从母液中分离出所得的晶体。
• BIODEGRADABLE POLYMER - BIOACTIVE MOIETY CONJUGATES
  申请人：O'Shea Michael Shane

  公开号：US20110243884A1

  公开（公告）日：2011-10-06

  The invention relates to a biodegradable polymer comprising a plurality of releasable bioactive moieties, the releasable bioactive moieties being pendant from and covalently bonded to the biodegradable polymer backbone, wherein the biodegradable polymer backbone is formed from monomeric units that are each coupled via a biodegradable moiety, and wherein the bioactive moieties are capable of being released at a rate equal to or faster than the rate of biodegradation of the polymer backbone.

  该发明涉及一种可生物降解的聚合物，其包含多个可释放的生物活性基团，这些可释放的生物活性基团悬挂在并与可生物降解的聚合物主链上共价键合，其中可生物降解的聚合物主链由通过可生物降解基团耦合的单体单元形成，而生物活性基团能够以与聚合物主链的降解速率相等或更快的速率释放出来。
• Biodegradable polymer—bioactive moiety conjugates
  申请人：O'Shea Michael Shane

  公开号：US08535655B2

  公开（公告）日：2013-09-17

  The invention relates to a biodegradable polymer comprising a plurality of releasable bioactive moieties, the releasable bioactive moieties being pendant from and covalently bonded to the biodegradable polymer backbone, wherein the biodegradable polymer backbone is formed from monomeric units that are each coupled via a biodegradable moiety, and wherein the bioactive moieties are capable of being released at a rate equal to or faster than the rate of biodegradation of the polymer backbone.

  该发明涉及一种可生物降解的聚合物，其包含多个可释放的生物活性基团，这些可释放的生物活性基团悬挂在并与可生物降解的聚合物主干共价键合，其中可生物降解的聚合物主干由通过可生物降解基团耦合的单体单元形成，而生物活性基团能够以等于或快于聚合物主干生物降解速率的速率释放。
• Carlsen, Per H. J.; Misund, Kristin; Roee, Johan, Acta Chemica Scandinavica, 1995, vol. 49, # 4, p. 297 - 300
  作者：Carlsen, Per H. J.、Misund, Kristin、Roee, Johan

  DOI：——

  日期：——
• POLYMER-BIOACTIVE AGENT CONJUGATES
  申请人：The Bionic Ear Institute

  公开号：EP2340271A1

  公开（公告）日：2011-07-06