3,8-bis(tert-butyloxycarbonylamino)-6-phenylphenanthridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3,8-bis(tert-butyloxycarbonylamino)-6-phenylphenanthridine
• 英文别名: tert-butyl N-[3-[(2-methylpropan-2-yl)oxycarbonylamino]-6-phenylphenanthridin-8-yl]carbamate
• 化学式: C₂₉H₃₁N₃O₄
• 分子量: 485.583
• InChiKey: IZINVFNJVBBSQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  36
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,8-bis(tert-butyloxycarbonylamino)-6-phenylphenanthridine 在 sodium cyanoborohydride 作用下， 以 四氢呋喃 为溶剂， 生成 tert-butyl N-[5-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]-6-phenyl-6H-phenanthridin-8-yl]carbamate
  参考文献：
  名称：

  [EN] DIHYDROETHIDINE ANALOGUES AND USES THEREOF
  [FR] ANALOGUES DE DIHYDROÉTHIDINE ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2011084585A3
• 作为产物：
  描述：

  二碳酸二叔丁酯 、 3,8-二氨基-6-苯基菲啶 生成 3,8-bis(tert-butyloxycarbonylamino)-6-phenylphenanthridine
  参考文献：
  名称：

  [EN] DIHYDROETHIDINE ANALOGUES AND USES THEREOF
  [FR] ANALOGUES DE DIHYDROÉTHIDINE ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2011084585A3

文献信息

• Fabrication of Chemical Microarrays by Efficient Immobilization of Hydrazide-Linked Substances on Epoxide-Coated Glass Surfaces
  作者：Myung-ryul Lee、Injae Shin

  DOI：10.1002/anie.200462720

  日期：2005.5.6
• DIHYDROETHIDINE ANALOGUES AND USES THEREOF
  申请人：Mach Robert H.

  公开号：US20130079522A1

  公开（公告）日：2013-03-28

  Tracers for imaging distribution of reactive oxygen species (ROS) are disclosed. The tracers include radiolabeled dihydroethidine (DHE) analogues. Further disclosed are uses of the compounds, including methods of imaging tissue distribution of ROS in vivo by positron emission tomography (PET). Methods of synthesizing the compounds are also disclosed.
• US9035057B2
  申请人：——

  公开号：US9035057B2

  公开（公告）日：2015-05-19
• [EN] VITAL FLUOROCHROME CONJUGATES AND METHODS OF USE<br/>[FR] CONJUGUÉS DE FLUOROCHROME VITAUX ET PROCÉDÉS D'UTILISATION
  申请人：GEN HOSPITAL CORP

  公开号：WO2010141833A2

  公开（公告）日：2010-12-09

  The present invention provides compositions and methods based on vital fluorochrome conjugates that are useful for imaging dying and dead cells.
• [EN] NONCOVALENT TAGS AND RELATED METHODS FOR CYTOSOLIC DELIVERY OF MACROBIOMOLECULES<br/>[FR] ÉTIQUETTES NON COVALENTES ET MÉTHODES ASSOCIÉES DESTINÉES À FAIRE PARVENIR DES MACROBIOMOLÉCULES DANS LE CYTOSOL
  申请人：UNIV WASHINGTON

  公开号：WO2020160499A1

  公开（公告）日：2020-08-06

  The disclosure provides bifunctional tag constructs and related methods useful for transporting macrobiomolecules, such as nucleic acids and proteins, across plasma membranes. The bifunctional tags comprise an affinity domain conjugated to hydrophobic domain. The affinity domain is configured to noncovalently bind to the macrobiomolecule, whereas the hydrophobic domain is configured to interact with the plasma membrane. In certain embodiments, the plurality of bifunctional tags can noncovalently associate along the length of a macrobiomolecule, thus increasing the interaction with and penetration through the plasma membrane.