4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid imidazolide | 1133823-83-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid imidazolide
• 英文别名: 3-(imidazole-1-carbonyl)-4-methyl-1H-quinolin-2-one
• CAS: 1133823-83-2
• 化学式: C₁₄H₁₁N₃O₂
• 分子量: 253.26
• InChiKey: SJVBHNOJMNDDJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.72
• 重原子数：
  19.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  67.75
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid imidazolide 在 盐酸 作用下， 以 四氯化碳 为溶剂， 反应 0.25h， 生成 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid chloride
  参考文献：
  名称：

  4-羟基-2-喹诺酮类150 *。4-甲基-2-氧代-1,2-二氢喹啉-3-羧酸烷基酰胺的高效合成，结构和生物学活性

  摘要：

  A simple and efficient method for preparing 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkyl amides is proposed. The results of a study of the diuretic activity of the compounds synthesized are reported.

  DOI：

  10.1007/s10593-009-0209-7
• 作为产物：
  描述：

  N,N'-羰基二咪唑 、 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 生成 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid imidazolide
  参考文献：
  名称：

  4-羟基-2-喹诺酮类150 *。4-甲基-2-氧代-1,2-二氢喹啉-3-羧酸烷基酰胺的高效合成，结构和生物学活性

  摘要：

  A simple and efficient method for preparing 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkyl amides is proposed. The results of a study of the diuretic activity of the compounds synthesized are reported.

  DOI：

  10.1007/s10593-009-0209-7

文献信息

• 4-Hydroxy-2-quinolones 142. 4-Methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides as potential diuretics
  作者：I. V. Ukrainets、N. L. Bereznyakova、V. A. Parshikov、O. I. Naboka

  DOI：10.1007/s10593-008-0029-1

  日期：2008.2

  A large series of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides has been prepared as potential diuretic agents. The effect of all of the synthesized compounds on the urinary function of the kidney has been investigated. The appearance of a "structure - diuretic activity" relationship is discussed.
• 4-hydroxy-2-quinolones. 153*. Synthesis of hetarylamides of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid
  作者：I. V. Ukrainets、N. L. Bereznyakova、V. A. Parshikov

  DOI：10.1007/s10593-009-0266-y

  日期：2009.3

  4-Methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hetarylamides can be prepared by two fundamentally different routes with allowance made for the thermal stability of the starting hetarylamines.