1,4-dioxaspiro[4.5]decan-8-yl acetate | 54621-09-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,4-dioxaspiro[4.5]decan-8-yl acetate
• 英文别名: 4.4-Ethylendioxycyclohexyl-acetat
• CAS: 54621-09-9
• 化学式: C₁₀H₁₆O₄
• 分子量: 200.235
• InChiKey: AWDZDJSARGZRJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4-dioxaspiro[4.5]decan-8-yl acetate 在 diethylzinc 、 lithium chloride 、 sodium hydroxide 作用下， 以 四氢呋喃 、 正己烷 、 水 为溶剂， 反应 14.0h， 以98%的产率得到4-羟基环己酮乙二醇缩醛
  参考文献：
  名称：

  轻度条件下高效高效的锌选择性化学催化的锌氢化硅烷化

  摘要：

  使用二乙基锌作为催化剂，已开发出一种温和而高效的催化氢化硅烷化方案，可用于室温酯的还原。该方法操作简单，显示出较高的官能团耐受性，并且可以轻松获得各种不同醇的高收率。

  DOI：

  10.1002/chem.201406176
• 作为产物：
  描述：

  1,4-环己二酮单乙二醇缩酮 在 吡啶 、 甲醇 、 sodium tetrahydroborate 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 1,4-dioxaspiro[4.5]decan-8-yl acetate
  参考文献：
  名称：

  [EN] TARGETED DELIVERY OF 1, 2, 4, 5-TETRAOXANE COMPOUNDS AND THEIR USES
  [FR] ADMINISTRATION CIBLÉE DE COMPOSÉS DE 1,2,4,5-TÉTRAOXANE ET LEURS UTILISATIONS

  摘要：

  1, 2, 4, 5-tetraoxane compounds and derivatives thereof that have anticancer properties are disclosed. Pharmaceutical compositions and pharmaceutical formulations in unit dosage form suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical compositions or formulations may include one or more active agents in addition to the compounds, such as one or more additional anticancer agents. Methods for treating a cancer, reducing a cancer, or treating or ameliorating one or more symptoms associated with a cancer in a subject are also disclosed. The methods include (i) administering to a subject in need thereof an effective amount of the compound (s). The compound (s) can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. The compound can selectively kill cancer cells and/or cancer stem cells over non-cancerous cells by triggering ferroptosis in the cancer cells and/or cancer stem cells.

  公开号：

  WO2022161490A1

文献信息

• Highly Efficient and Chemoselective Zinc-Catalyzed Hydrosilylation of Esters under Mild Conditions
  作者：Oleksandr O. Kovalenko、Hans Adolfsson

  DOI：10.1002/chem.201406176

  日期：2015.2.9

  A mild and highly efficient catalytic hydrosilylation protocol for room‐temperature ester reductions has been developed using diethylzinc as the catalyst. The methodology is operationally simple, displays high functional group tolerance and provides for a facile access to a broad range of different alcohols in excellent yields.

  使用二乙基锌作为催化剂，已开发出一种温和而高效的催化氢化硅烷化方案，可用于室温酯的还原。该方法操作简单，显示出较高的官能团耐受性，并且可以轻松获得各种不同醇的高收率。
• [EN] TARGETED DELIVERY OF 1, 2, 4, 5-TETRAOXANE COMPOUNDS AND THEIR USES<br/>[FR] ADMINISTRATION CIBLÉE DE COMPOSÉS DE 1,2,4,5-TÉTRAOXANE ET LEURS UTILISATIONS
  申请人：[en]YANG, Dan

  公开号：WO2022161490A1

  公开（公告）日：2022-08-04

  1, 2, 4, 5-tetraoxane compounds and derivatives thereof that have anticancer properties are disclosed. Pharmaceutical compositions and pharmaceutical formulations in unit dosage form suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical compositions or formulations may include one or more active agents in addition to the compounds, such as one or more additional anticancer agents. Methods for treating a cancer, reducing a cancer, or treating or ameliorating one or more symptoms associated with a cancer in a subject are also disclosed. The methods include (i) administering to a subject in need thereof an effective amount of the compound (s). The compound (s) can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. The compound can selectively kill cancer cells and/or cancer stem cells over non-cancerous cells by triggering ferroptosis in the cancer cells and/or cancer stem cells.