methyl 6-deoxy-6-(morpholin-4-yl)-2,3,4-tri-O-benzyl-α-D-glucopyranoside

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 6-deoxy-6-(morpholin-4-yl)-2,3,4-tri-O-benzyl-α-D-glucopyranoside
• 英文别名: 4-[[(2R,3R,4S,5R,6S)-6-methoxy-3,4,5-tris(phenylmethoxy)oxan-2-yl]methyl]morpholine
• 化学式: C₃₂H₃₉NO₆
• 分子量: 533.665
• InChiKey: QZOSZBPMLVLJRT-VJLURNNQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  58.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  methyl 2,3,4-tri-O-benzyl-6-O-trifluoromethylsulfonyl-α-D-glucopyranoside 在 氨 、 臭氧 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 48.0h， 生成 methyl 6-deoxy-6-(morpholin-4-yl)-2,3,4-tri-O-benzyl-α-D-glucopyranoside
  参考文献：
  名称：

  Synthetic entry to functionalised morpholines and [1,4]-oxazepanes via reductive amination reactions of carbohydrate derived dialdehydes

  摘要：

  The rapid synthesis of functionalised morpholines and [1,4]-oxazepanes displaying up to three stereocentres, by reductive amination reactions between carbohydrate derived dialdehydes and a range of amines, is described. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.10.002

文献信息

• Synthetic entry to functionalised morpholines and [1,4]-oxazepanes via reductive amination reactions of carbohydrate derived dialdehydes
  作者：Stuart M. Clark、Helen M.I. Osborn

  DOI：10.1016/j.tetasy.2004.10.002

  日期：2004.11

  The rapid synthesis of functionalised morpholines and [1,4]-oxazepanes displaying up to three stereocentres, by reductive amination reactions between carbohydrate derived dialdehydes and a range of amines, is described. (C) 2004 Elsevier Ltd. All rights reserved.