4-{4-[(4-bromo-phenylimino)-methyl]-phenoxymethyl}-6-methyl-chromen-2-one | 1095704-50-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-{4-[(4-bromo-phenylimino)-methyl]-phenoxymethyl}-6-methyl-chromen-2-one
• 英文别名: 4-{4-[(4-bromophenylimino)methyl]-phenoxymethyl}-6-methyl-chromen-2-one；4-[[4-[(4-Bromophenyl)iminomethyl]phenoxy]methyl]-6-methylchromen-2-one
• CAS: 1095704-50-9
• 化学式: C₂₄H₁₈BrNO₃
• 分子量: 448.316
• InChiKey: UCGVZANXNJOKQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  47.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-{4-[(4-bromo-phenylimino)-methyl]-phenoxymethyl}-6-methyl-chromen-2-one 、 巯基乙酸 在 zinc(II) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以40%的产率得到3-(4-bromophenyl)-2-[4-(6-methyl-2-oxo-2H-chromen-4-ylmethoxy)phenyl]-thiazolidin-4-one
  参考文献：
  名称：

  Synthetic and Biological Studies on 4-Aryloxymethyl Coumarinyl Thiazolidinones

  摘要：

  A series of new thiazolidinonyl-4-aryloxymetlaylcoumarins (4a-h) have been synthesized from 4-Bromomethylcoumarins (1a-b) and 4-aryliminomethyl-phenols (2a-d). Structures of all the new compounds are elucidated by elemental analyses, IR, H-1 NMR, and mass spectral data. All these compounds have been subjected to in-vitro antimicrobial and in-vivo anti-inflammatory screening.

  DOI：

  10.1080/10426500701555801
• 作为产物：
  描述：

  4-hydroxybenzal-4-bromoaniline 、 6-methyl-4-bromomethylcoumarin 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 24.0h， 以66%的产率得到4-{4-[(4-bromo-phenylimino)-methyl]-phenoxymethyl}-6-methyl-chromen-2-one
  参考文献：
  名称：

  Synthetic and Biological Studies on 4-Aryloxymethyl Coumarinyl Thiazolidinones

  摘要：

  A series of new thiazolidinonyl-4-aryloxymetlaylcoumarins (4a-h) have been synthesized from 4-Bromomethylcoumarins (1a-b) and 4-aryliminomethyl-phenols (2a-d). Structures of all the new compounds are elucidated by elemental analyses, IR, H-1 NMR, and mass spectral data. All these compounds have been subjected to in-vitro antimicrobial and in-vivo anti-inflammatory screening.

  DOI：

  10.1080/10426500701555801

文献信息

• Synthetic and Biological Studies on 4-Aryloxymethyl Coumarinyl Thiazolidinones
  作者：K. Shivashankar、Lokesh A. Shastri、Manohar V. Kulkarni、Vijaykumar P. Rasal、Sandur V. Rajendra

  DOI：10.1080/10426500701555801

  日期：2007.12.24

  A series of new thiazolidinonyl-4-aryloxymetlaylcoumarins (4a-h) have been synthesized from 4-Bromomethylcoumarins (1a-b) and 4-aryliminomethyl-phenols (2a-d). Structures of all the new compounds are elucidated by elemental analyses, IR, H-1 NMR, and mass spectral data. All these compounds have been subjected to in-vitro antimicrobial and in-vivo anti-inflammatory screening.
• RETRACTED: 2-Azetidinone derivatives: Design, synthesis, in vitro anti-microbial, cytotoxic activities and DNA cleavage study
  作者：Rangappa S. Keri、Kallappa M. Hosamani、Ramya V. Shingalapur、Harisha R. Seetharama Reddy

  DOI：10.1016/j.ejmech.2009.09.011

  日期：2009.12

  A novel series of 3-chloro-4-[4-(2-oxo-2H-chromen-4-ylmethoxy)-phenyl]-1-phenyl-azetidin-2-one derivatives (5a-j) have been synthesized from 4-aryloxymethylcoumarins (la-e) and 4-aryliminomethylphenols (3a-b). The title compounds were screened for their in vitro anti-bacterial and anti-fungal activities. Results revealed that, compounds (5c), (5f), (5h) and (5j) showed excellent anti-microbial activity against a panel of microorganisms. Brine shrimp bioassay was also carried out to study their in vitro cytotoxic properties among which (5h) and (5j) displayed potent cytotoxic activity against Artemia salina. The DNA cleavage activity of some compounds was studied by agarose gel electrophoresis method. All synthesized compounds were characterized using IR, H-1 NMR, C-13 NMR, MS and elemental analysis. (C) 2009 Elsevier Masson SAS. All rights reserved.