(R)-((2S)-3t,4c-dihydroxy-tetrahydro-[2r]furyl)-hydroxy-acetic acid | 54060-56-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (R)-((2S)-3t,4c-dihydroxy-tetrahydro-[2r]furyl)-hydroxy-acetic acid
• 英文别名: (R)-((2S)-3t,4c-Dihydroxy-tetrahydro-[2r]furyl)-hydroxy-essigsaeure；(2R)-2-[(2S,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyacetic acid
• CAS: 54060-56-9
• 化学式: C₆H₁₀O₆
• 分子量: 178.142
• InChiKey: ZDDQAAZBPZGPRB-LECHCGJUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (R)-((2S)-3t,4c-dihydroxy-tetrahydro-[2r]furyl)-hydroxy-acetic acid 在 氯化亚砜 、 三氟乙酸 作用下， 以 甲苯 为溶剂， 反应 1.5h， 生成
  参考文献：
  名称：

  通过转化为相应的非对映体乙酰化3,6-脱水半乳糖仲丁基对映体，分离和定量对映体3,6-脱水半乳糖

  摘要：

  摘要以甲基3,6-脱水-α-d-半乳糖苷为模型化合物，建立了测定样品中3,6-脱水半乳糖对映体比例的方法。它涉及氧化水解以获得相应的醛糖酸，将其进一步转化为乙酰化的非对映异构的仲丁酯。使用标准柱进行碳水化合物分析，并通过GLC进行分离和定量；该程序已扩展到海藻多糖。

  DOI：

  10.1016/s0008-6215(98)00215-8
• 作为产物：
  描述：

  D-半乳糖酸-1,4-内酯 在 氢溴酸 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 74.0h， 生成 (R)-((2S)-3t,4c-dihydroxy-tetrahydro-[2r]furyl)-hydroxy-acetic acid
  参考文献：
  名称：

  Enantiomerically pure, highly functionalized tetrahydrofurans from simple carbohydrate precursors

  摘要：

  6-Bromo-6-deoxy-1,4-aldonolactones and 6-bromo-6-deoxy-alditols with D-galacto-, D-altro-, D-manno- and D-ido-configuration were selectively converted into hydroxylated tetrahydrofuran derivatives by simple heating in water. The 6-bromo-6-deoxy-D-altritol (10) and 6-bromo-6-deoxy-D-iditol (25) reacted even at room temperature. Likewise, the 6-bromo-2,6-dideoxy-aldonolactones with D-arabino- (29) and D-lyxo-configuration (31) gave the corresponding 2-deoxy-3,6-anhydrides, when heated in water. The rate of formation of the furan ring by intramolecular nucleophilic substitution was determined by the conformation of the bromopolyols in water.

  DOI：

  10.1016/s0040-4020(01)89337-6

文献信息

• Haworth et al., Journal of the Chemical Society, 1940, p. 620,629
  作者：Haworth et al.

  DOI：——

  日期：——
• EP2995684A1
  申请人：——

  公开号：EP2995684A1

  公开（公告）日：2016-03-16
• RECOMBINANT MICROORGANISM METABOLIZING 3,6-ANHYDRIDE-L-GALACTOSE AND A USE THEREOF
  申请人：Korea University Research and Business Foundation

  公开号：EP2995684B1

  公开（公告）日：2019-07-03
• NOVEL MARINE BACTERIUM OF METABOLIZING 3,6-ANHYDRO-L-GALACTOSE AND USE OF THE SAME
  申请人：KIM Kyoung Heon

  公开号：US20130102036A1

  公开（公告）日：2013-04-25

  Disclosed is a novel marine microorganism which can metabolize 3,6-anhydro-L-galactose and use of the same. The novel marine microorganism belongs to Vibrio sp. which utilizes 3,6-anhydro-L-galactose (3,6-L-AHG) as a single carbon source to convert 3,6-L-AHG to ribose and 3,6-anhydrogalactonic acid.
• NOVEL 3,6-ANHYDRO-L-GALACTOSE DEHYDROGENASE ACTING ON 3,6-ANHYDRO-L-GALACTOSE, AND PRODUCTION OF 3,6-ANHYDROGALACTONIC ACID BY USING THE ENZYME
  申请人：Choi In-Geol

  公开号：US20130303743A1

  公开（公告）日：2013-11-14

  The present invention relates to a novel 3,6-anhydro-L-galactose dehydrogenase and to a novel compound produced therefrom. More specifically, provided is a 3,6-anhydro-L-galactose dehydrogenase which can produce 3,6-anhydrogalactonic acid of a novel type by metabolizing 3,6-anhydro-L-galactose.