2-methacryloyloxyethyl-D-mannoside | 132153-56-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methacryloyloxyethyl-D-mannoside
• 英文别名: Mannosyloxyethyl methacrylate；2-[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyethyl 2-methylprop-2-enoate
• CAS: 132153-56-1
• 化学式: C₁₂H₂₀O₈
• 分子量: 292.286
• InChiKey: KUQRLZZWFINMDP-AIXJAHFHSA-N

物化性质

• 沸点：
  490.3±45.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  甲基丙烯酸羟乙酯 、 甲基-D-丙噻 在 phosphomolybdic acid 1-氯-2,4-二硝基苯 作用下， 以 氯苯 为溶剂， 反应 0.5h， 生成 2-methacryloyloxyethyl-D-mannoside
  参考文献：
  名称：

  Syntheses and Properties of Novel Vinyl Monomers Bearing a Glycoside Residue

  摘要：

  具有单糖残基的新型丙烯酸单体在杂多酸存在下，通过某些甲基糖苷与2-羟乙基丙烯酸酯或甲基丙烯酸酯反应合成。这些单体均具有良好的水溶性，并能被自由基引发剂快速聚合。

  DOI：

  10.1246/cl.1990.1733

文献信息

• [EN] STABLE PROTEIN LIGANDS AS ANTI-INFECTIVE AGENTS<br/>[FR] LIGANDS PROTÉIQUES STABLES UTILISÉS EN TANT QU'AGENTS ANTI-INFECTIEUX
  申请人：UNIV MONASH

  公开号：WO2019227173A1

  公开（公告）日：2019-12-05

  The present invention relates to compounds that inhibit the interaction between the SPRY-domain containing SOCS box protein and inducible nitric oxide synthase (iNOS). In particular, the present invention relates to compounds of Formula (I) and their use as anti- infective agents. (I)

  本发明涉及抑制SPRY域含SOCS盒蛋白与诱导型一氧化氮合酶（iNOS）相互作用的化合物。特别地，本发明涉及公式（I）的化合物及其作为抗感染剂的用途。(I)
• POLYMER HAVING VISIBILITY IN MAGNETIC RESONANCE IMAGE AND SURFACE LUBRICITY AND MEDICAL DEVICE
  申请人：Kurita Tomoka

  公开号：US20100019189A1

  公开（公告）日：2010-01-28

  Provided are a polymer which, when wetted, enables a medical apparatus for use in MRI diagnosis and therapy to be easily visible under MRI and, simultaneously, develops surface lubricity, and a medical apparatus coated with the polymer. The polymer including a copolymer composed of a substance for shortening relaxation time of a nuclear species capable of being detected by magnetic resonance, a moiety having a reactive group, and a moiety for developing lubricity is used to coat the medical apparatus, whereby excellent peel resistance, high lubricity, visibility under magnetic resonance, easy applicability, and high safety can be obtained.

  提供了一种聚合物，当它被润湿时，可以使用于MRI诊断和治疗的医疗器械在MRI下易于观察，并同时具有表面润滑性，以及用该聚合物涂覆的医疗器械。该聚合物包括由一种缩短核物种弛豫时间的物质、具有反应性基团的基团和用于发展润滑性的基团组成的共聚物，用于涂覆医疗器械，可以获得优异的剥离抗力、高润滑性、MRI下的可见性、易于应用和高安全性。
• Medical device having wet lubricity and method for its production
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP1103278A2

  公开（公告）日：2001-05-30

  A highly safe medical device which exhibits long-lasting low surface friction in a body fluid or in an aqueous medium is provided. Also provided is a method for producing such medical device wherein substantially no limitation is imposed on the type of the substrate used, and the hydrophilic high molecular weight compound or the water-soluble or water-swellable high molecular weight compound responsible for the surface lubricity can be readily coated on the surface. In the present invention, a hydrophilic high molecular weight compound having at least one carbonyl group or hydrazine residue in the molecule and a cross-linking agent having at least two hydrazine residues or carbonyl groups in the molecule are reacted to thereby form a surface lubrication layer comprising the reaction product. In another embodiment, an interpenetrating network is formed between the reaction product of a compound having at least one carbonyl group or hydrazine residue in the molecule and a cross-linking agent, and a water-soluble or water-swellable high molecular weight compound to thereby form a surface lubrication layer.

  本发明提供了一种高度安全的医疗器械，它在体液或水介质中表现出持久的低表面摩擦力。本发明还提供了一种生产这种医疗器械的方法，该方法对所用基材的类型基本没有限制，而且亲水性高分子量化合物或具有表面润滑性的水溶性或水溶性高分子量化合物可以很容易地涂覆在基材表面。在本发明中，分子中至少有一个羰基或肼残基的亲水性高分子量化合物和分子中至少有两个肼残基或羰基的交联剂发生反应，从而形成由反应产物组成的表面润滑层。在另一个实施方案中，在分子中至少有一个羰基或肼残基的化合物和交联剂的反应产物与水溶性或水溶性高分子量化合物之间形成互穿网络，从而形成表面润滑层。
• METHOD FOR PRODUCING MEDICAL DEVICE
  申请人：Terumo Kabushiki Kaisha

  公开号：EP2583699A1

  公开（公告）日：2013-04-24

  Disclosed is a method for firmly fixing a hydrophilic polymer on a polyamide surface. The method is characterized by including a step of applying a solution containing a phenolic compound to a base material of which at least a part of the surface is a polyamide and a step of coating the base material with a hydrophilic polymer after the application step.

  本发明公开了一种在聚酰胺表面牢固固定亲水性聚合物的方法。该方法的特点是包括以下步骤：将含有酚类化合物的溶液涂抹在基材上，基材表面至少有一部分是聚酰胺；涂抹步骤结束后，在基材上涂抹亲水性聚合物。
• MEDICAL DEVICE
  申请人：Terumo Kabushiki Kaisha

  公开号：EP2589344A1

  公开（公告）日：2013-05-08

  Disclosed is a device capable of providing a space, said space allowing a medical instrument to move, in an area of the brain in which the medical instrument can hardly move. Specifically disclosed is a medical device which comprises a catheter provided with an expandable member, characterized in that said expandable member is expanded to provide a space in which at least a part of a second medical instrument can move.

  本发明公开了一种能够在医疗器械难以移动的大脑区域提供空间的装置，所述空间允许医疗器械移动。具体地说，本发明公开了一种医疗器械，它包括一个带有可膨胀部件的导管，其特征在于所述可膨胀部件膨胀后可提供一个空间，在该空间中，第二医疗器械的至少一部分可以移动。