6-methyl-N-(5-methylisoxazol-3-yl)-2-(pyridin-3-yl)quinoline-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-methyl-N-(5-methylisoxazol-3-yl)-2-(pyridin-3-yl)quinoline-4-carboxamide
• 英文别名: 6-methyl-N-(5-methyl-1,2-oxazol-3-yl)-2-(pyridin-3-yl)quinoline-4-carboxamide；6-methyl-N-(5-methyl-1,2-oxazol-3-yl)-2-pyridin-3-ylquinoline-4-carboxamide
• 化学式: C₂₀H₁₆N₄O₂
• 分子量: 344.373
• InChiKey: JGIKKTMKAMYYQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  80.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-氨基-5-甲基异恶唑 、 6-甲基-2-(3-吡啶基)喹啉-4-羧酸 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以39%的产率得到6-methyl-N-(5-methylisoxazol-3-yl)-2-(pyridin-3-yl)quinoline-4-carboxamide
  参考文献：
  名称：

  [EN] QUINOLINE COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF
  [FR] COMPOSÉS DE QUINOLÉINE UTILISÉS EN TANT QUE MODULATEURS DE L'ACTIVITÉ DE RAGE ET LEURS UTILISATIONS

  摘要：

  披露了具有以下公式表示的喹啉化合物：其中Cy、R1、R4a、R4b和n如本文所述。这些化合物可以制备为药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的各种疾病，例如糖尿病并发症、炎症、神经退行性疾病、肥胖、癌症、缺血/再灌注损伤、心血管疾病和其他与RAGE活性相关的疾病。

  公开号：

  WO2017184547A1

文献信息

• Quinoline compounds as modulators of RAGE activity and uses thereof
  申请人：NEW YORK UNIVERSITY

  公开号：US11192859B2

  公开（公告）日：2021-12-07

  Quinoline compounds are disclosed that have a formula represented by the following: and wherein Cy, R1, R4a, R4b, and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.

  所公开的喹啉化合物具有下式所代表的式子： 其中 Cy、R1、R4a、R4b 和 n 如本文所述。这些化合物可制备成药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的各种疾病，包括非限制性的糖尿病并发症、炎症、神经变性、肥胖、癌症、缺血/再灌注损伤、心血管疾病和其他与 RAGE 活性有关的疾病。
• QUINOLINE COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF
  申请人：NEW YORK UNIVERSITY

  公开号：US20190194136A1

  公开（公告）日：2019-06-27

  Quinoline compounds are disclosed that have a formula represented by the following: and wherein Cy, R 1 , R 4a , R 4b , and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.
• [EN] QUINOLINE COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF<br/>[FR] COMPOSÉS DE QUINOLÉINE UTILISÉS EN TANT QUE MODULATEURS DE L'ACTIVITÉ DE RAGE ET LEURS UTILISATIONS
  申请人：UNIV NEW YORK

  公开号：WO2017184547A1

  公开（公告）日：2017-10-26

  Quinoline compounds are disclosed that have a formula represented by the following: and wherein Cy, R1, R4a, R4b, and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.

  披露了具有以下公式表示的喹啉化合物：其中Cy、R1、R4a、R4b和n如本文所述。这些化合物可以制备为药物组合物，并可用于预防和治疗包括人类在内的哺乳动物的各种疾病，例如糖尿病并发症、炎症、神经退行性疾病、肥胖、癌症、缺血/再灌注损伤、心血管疾病和其他与RAGE活性相关的疾病。