1,3-bis(aminooxy)propane dihydrochloride

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,3-bis(aminooxy)propane dihydrochloride
• 英文别名: O,O'-1,3-propanediylbishydroxylamine dihydrochloride；O,O'-(Propane-1,3-diyl)bis(hydroxylamine) hydrochloride；O-(3-aminooxypropyl)hydroxylamine;hydrochloride
• 化学式: C₃H₁₀N₂O₂*2ClH
• 分子量: 179.046
• InChiKey: ZUMGIQPLFQOCAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.42
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  70.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  丹酰氯 、 1,3-bis(aminooxy)propane dihydrochloride 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以17%的产率得到N-(3-(aminooxy)propoxy)-5-(dimethylamino)naphthalene-1-sulfonamide
  参考文献：
  名称：

  [EN] FLUORESCENT PROBES FOR ABASIC SITE DETECTION
  [FR] SONDES FLUORESCENTES POUR UNE DÉTECTION DU SITE ABASIQUE

  摘要：

  公开号：

  WO2016168467A3
• 作为产物：
  描述：

  1,3-diaminoxypropanebis(5-norbornene-2,3-dicarboxy)imide 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 0.25h， 以50%的产率得到1,3-bis(aminooxy)propane dihydrochloride
  参考文献：
  名称：

  Imine exchange inO-aryl andO-alkyl oximes as a base reaction for aqueous ‘dynamic’ combinatorial libraries. A kinetic and thermodynamic study

  摘要：

  Kinetics and mechanisms of the imine exchange reactions of O-alkyl and O-aryl oximes with O-alkyl and O-aryloxyamines, respectively, were studied by H-1 NMR spectroscopy in aqueous solutions,The reaction between benzaldehyde O-methyloxime and O-ethylhydroxylamine at 60 degrees C is first order in both oxime and the alkoxylamine (the second-order rate constant k(2) = 0.86 +/- 0.08 l mol(-1) min(-1) at pD 2.9), the reaction being subject to acidic catalysis. A similar imine transfer was studied in the reaction of 1,3-diaminooxypropane with bifunctional oximes. Testing of various additives as potential catalysts for the reaction revealed imidazole as a moderately effective catalyst. The exchange in O-aryl oximes was studied in the interaction between 3-pyridinealdehyde O-phenyloxime and O-(p-nitrophenyl)hydroxylamine. The reaction is first order in the oxime, but its rate is independent on the aryloxyamine concentration and pD. The proposed mechanism involves a rate-limiting hydration of the oxime molecule. Mechanisms of the exchange reactions are discussed in relation to their possible use to generate diverse pools of compounds for the recently proposed 'dynamic' combinatorial chemistry approach. Copyright (C) 1999 John Wiley & Sons, Ltd.

  DOI：

  10.1002/(sici)1099-1395(199905)12:5<357::aid-poc129>3.0.co;2-y

文献信息

• Modification of Factor VIII
  申请人：Zundel Magali

  公开号：US20110306551A1

  公开（公告）日：2011-12-15

  A Factor VIII derivative of formula (I): wherein: B represents C 2 to C 10 alkylene; m represents 0 or an integer from 1 to 19, n represents an integer from 1 to 20, and the sum of m and n is from 1 to 20; P represents a mono or polyradical of Factor VIII obtained by removing m+n carbamoyl groups from the side chains of glutamine residues in Factor VIII; and M represents a moiety (M 1 ) that increases the plasma half-life of the Factor VIII derivative or a reporter moiety (M 2 ); or a pharmaceutically acceptable salt thereof.

  公式（I）的因子VIII衍生物：其中：B代表C2到C10烷基；m代表0或1到19之间的整数，n代表1到20之间的整数，m和n的和为1到20；P代表通过从因子VIII的谷氨酰残基的侧链中去除m+n个氨基甲酰基团而获得的因子VIII的单基或多基团；M代表增加因子VIII衍生物血浆半衰期的团（M1）或报告团（M2）；或其药用盐。
• Synthesis of Novel Adamantylalkoxyurea Derivatives from 2-(1-Adamantylimino)-1,3-oxathiolane
  作者：Andrey Shirayev、Paul Kong Thoo lin、Igor K. Moiseev

  DOI：10.1055/s-1997-1510

  日期：1997.1

  2-(1-Adamantylimino)-5-methyl-1,3-oxathiolane 1 was synthesised from the reaction between adamantan-1-ol and 1-thiocyanopropan-2-ol in sulphuric acid. Compound 1 undergoes ring opening followed by elimination to afford novel adamantane alkoxyureas 3 a-d and 5 a, b with a number of oxyamino nucleophiles 2 a-d and 4 a, b.

  2-(1-金刚烷基亚氨基)-5-甲基-1,3-氧硫杂环戊烷 1 是由金刚烷-1-醇和 1-硫氰基丙烷-2-醇在硫酸中反应合成的。化合物 1 经过开环和消去反应，生成了新型金刚烷烷氧基脲 3 a-d 和 5 a、b，以及一些氧氨基亲核物 2 a-d 和 4 a、b。
• [EN] NOVEL MICROBIOCIDAL DIOXIME ETHER DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS ÉTHERS DE DIOXIME MICROBICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2012013754A1

  公开（公告）日：2012-02-02

  The present invention provides compounds of formula (I) wherein G1, G2, G3, G4, G5, G6, Y1, Y2, Y3, Y4, Y5 and Y6 and p and q are as defined in the claims. The invention further relates to compositions which comprise these compounds and to their use in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.

  本发明提供了式（I）中的化合物，其中G1、G2、G3、G4、G5、G6、Y1、Y2、Y3、Y4、Y5和Y6以及p和q如权利要求中所定义。本发明还涉及包含这些化合物的组合物，以及它们在农业或园艺中用于控制或预防植物受植物病原微生物，尤其是真菌的侵害的用途。
• Reducing-End Functionalization of 2,5-Anhydro-d-mannofuranose-Linked Chitooligosaccharides by Dioxyamine: Synthesis and Characterization
  作者：Maxence Coudurier、Jimmy Faivre、Agnès Crépet、Catherine Ladavière、Thierry Delair、Christophe Schatz、Stéphane Trombotto

  DOI：10.3390/molecules25051143

  日期：——

  The nitrous acid depolymerization of chitosan enables the synthesis of singular chitosan oligosaccharides (COS) since their reducing-end unit is composed of 2,5-anhydro-d-mannofuranose (amf). In the present study, we describe a chemical method for the reducing-end conjugation of COS-amf by the commercially available dioxyamine O,O′-1,3-propanediylbishydroxylamine in high mass yields. The chemical structure

  壳聚糖的亚硝酸解聚能够合成单一的壳寡糖 (COS)，因为它们的还原端单元由 2,5-脱水-d-呋喃甘露糖 (amf) 组成。在本研究中，我们描述了一种通过市售二氧胺 O,O'-1,3-丙二基双羟胺以高质量收率还原 COS-amf 末端共轭的化学方法。通过肟化和还原胺化方式合成的二氧胺连接的 COS-amf 的化学结构通过 1H-和 13C-NMR 光谱和 MALDI-TOF 质谱进行了充分表征。在 COS-amf 的还原端偶联具有化学吸引力的接头，例如二氧胺，形成了开发先进的基于 COS 的功能性偶联物的相关策略。
• Against the Norm: Non Irving–Williams Transmetalation in Transition Metal Dimers
  作者：Sidney S. Woodhouse、Tyson N. Dais、Alvaro Etcheverry-Berríos、Euan K. Brechin、Joseph R. Lane、Paul G. Plieger

  DOI：10.1021/acs.inorgchem.2c03113

  日期：2022.11.7

  We report the synthesis and characterization of three dinuclear 3d3d′ complexes, CuCu ([CuII2L(NO3)2] ), MnMn ([MnII2L(MeOH)2(NO3)2] ), and CuMn ([CuIIMnIIL(NO3)2]), that utilize the ligand, H2L (6,6′-dimethoxy-2,2’-[(1,3-propylene)dioxybis(nitrilomethylidyne)]diphenol). The relative stabilities of these complexes were investigated using experimental and computational techniques, revealing a non-Irving-Williams

  我们报告了三种双核 3 d 3 d ' 配合物CuCu ([ C u I I 2 L ( N O 3 ) 2 ] ),锰锰([ M n I I 2 L ( M e O H ) 2 ( N O 3 ) 2 ] ) 和CuMn ([Cu II Mn II L (NO 3 ) 2 ])，它们利用配体 H 2 L (6,6'-dimethoxy-2,2'-[(1,3-丙烯)dioxybis(次氮基亚甲基）]二苯酚）。使用实验和计算技术研究了这些配合物的相对稳定性，揭示了非 Irving-Williams 金属转移，其中 Mn II离子可以将 Cu II离子从其在CuCu中的结合袋中置换出来，从而产生更稳定的CuMn 配合物。所报道的配合物的磁性表征揭示了两个 Cu II之间的意外铁磁耦合J = +63.0 cm –1的CuCu离子。