N-(6-(4-hydroxyphenyl)quinolin-4-yl)-N-phenyl-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(6-(4-hydroxyphenyl)quinolin-4-yl)-N-phenyl-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide
• 英文别名: N-[6-(4-hydroxyphenyl)quinolin-4-yl]-N-phenyl-2,3-dihydro-1,4-benzodioxine-6-sulfonamide
• 化学式: C₂₉H₂₂N₂O₅S
• 分子量: 510.57
• InChiKey: XTRWTCKRPJZGGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  97.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6-溴-4-碘-喹啉 在 四(三苯基膦)钯 、 palladium diacetate 、 potassium carbonate 、 caesium carbonate 、 三乙胺 作用下， 以 1,4-二氧六环 、 甲苯 为溶剂， 反应 26.0h， 生成 N-(6-(4-hydroxyphenyl)quinolin-4-yl)-N-phenyl-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide
  参考文献：
  名称：

  4-(N-Phenyl-N′-substituted benzenesulfonyl)-6-(4-hydroxyphenyl)quinolines as inhibitors of mammalian target of rapamycin

  摘要：

  A series of 4-(N-phenyl-N'-substituted benzenesulfonyl)-6-(4-hydroxyphenyl) quinolines was designed, synthesized and evaluated for their biological potential as anticancer agents by screening the molecules against panel of five human cancer cell lines viz. HL-60, MiaPaCa-2, HCT116, PC-3 and HEP-G2. The series has shown good mTOR inhibitory activity at 0.5 mu M concentration. The representative compound 7h was found to be most active with the IC50 of 613 nM against mTOR. In supportive evidence, the western blotting experiment revealed that compound 7h is more potent in inhibiting p-mTOR (S2448) activity in 2-4 h at 5 and 10 mu M concentrations and was selective and specific towards mTORC1 versus mTORC2. Towards understanding the mechanistic aspects we studied cell cycle analysis, mitochondrial membrane potential loss in MiaPaca-2 cells for compound 7h. The docking study for this series was performed to understand the binding mode of the compounds and its consequent effect in biological activity, the initial interaction studies were found to be useful in design of molecules, where compound 7h has shown additional H-bond interaction with Lys2171 apart from Val2240 and also a small hydrophobic cleft was observed with Leu2185, Met2345 and Ile2356. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.06.046

文献信息

• 4-(N-Phenyl-N′-substituted benzenesulfonyl)-6-(4-hydroxyphenyl)quinolines as inhibitors of mammalian target of rapamycin
  作者：Vunnam Venkateswarlu、Anup Singh Pathania、K.A. Aravinda Kumar、Priya Mahajan、Amit Nargotra、Ram A. Vishwakarma、Fayaz A. Malik、Sanghapal D. Sawant

  DOI：10.1016/j.bmc.2015.06.046

  日期：2015.8

  A series of 4-(N-phenyl-N'-substituted benzenesulfonyl)-6-(4-hydroxyphenyl) quinolines was designed, synthesized and evaluated for their biological potential as anticancer agents by screening the molecules against panel of five human cancer cell lines viz. HL-60, MiaPaCa-2, HCT116, PC-3 and HEP-G2. The series has shown good mTOR inhibitory activity at 0.5 mu M concentration. The representative compound 7h was found to be most active with the IC50 of 613 nM against mTOR. In supportive evidence, the western blotting experiment revealed that compound 7h is more potent in inhibiting p-mTOR (S2448) activity in 2-4 h at 5 and 10 mu M concentrations and was selective and specific towards mTORC1 versus mTORC2. Towards understanding the mechanistic aspects we studied cell cycle analysis, mitochondrial membrane potential loss in MiaPaca-2 cells for compound 7h. The docking study for this series was performed to understand the binding mode of the compounds and its consequent effect in biological activity, the initial interaction studies were found to be useful in design of molecules, where compound 7h has shown additional H-bond interaction with Lys2171 apart from Val2240 and also a small hydrophobic cleft was observed with Leu2185, Met2345 and Ile2356. (C) 2015 Elsevier Ltd. All rights reserved.