(1S,5S,6R)-(cis,trans)-spiro[4.4]nonane-1,6-diol | 65167-79-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S,5S,6R)-(cis,trans)-spiro[4.4]nonane-1,6-diol
• CAS: 65167-79-5
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: ACIVJWAOSTYYEP-YIZRAAEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.06
• 重原子数：
  11.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.46
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  三氟甲磺酸酐 、 (1S,5S,6R)-(cis,trans)-spiro[4.4]nonane-1,6-diol 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 Trifluoro-methanesulfonic acid (1S,5S,6R)-6-trifluoromethanesulfonyloxy-spiro[4.4]non-1-yl ester
  参考文献：
  名称：

  手性恶唑硼烷催化的高效和立体定向硼烷还原螺[4,4]壬烷-1,6-二酮

  摘要：

  描述了由恶唑硼烷试剂催化的高度立体选择性和对映选择性还原外消旋螺[4,4]壬烷-1,6-二酮。外消旋螺二酮的不对称还原产生对映体纯的螺二醇，其是有用的手性助剂，也是合成其他高效手性配体的关键中间体。的反式，反式-和顺式，反式均在高对映体纯度通过手性采用恶唑硼烷作为催化剂制备-spirodiols。

  DOI：

  10.1016/s0040-4039(00)00606-7
• 作为产物：
  描述：

  (+/-)-trans-6-hydroxyspiro<4.4>nonan-1-one 以 水 为溶剂， 反应 72.0h， 生成 (1S,5S,6R)-(cis,trans)-spiro[4.4]nonane-1,6-diol 、 trans,trans-spiro<4.4>nonane-1,6-diol
  参考文献：
  名称：

  Microbial stereodifferentiating reduction of 1,6-spiro[4.4]nonanedione, a gyrochiral diketone with two homotopic carbonyl groups

  摘要：

  DOI：

  10.1021/jo00319a021

文献信息

• Asymmetric synthesis. Part 29: Asymmetric hydroformylation of styrene catalyzed by chiral spiro diphosphite–rhodium(I) complexes
  作者：Yaozhong Jiang、Song Xue、Zhi Li、Jingen Deng、Aiqiao Mi、Albert S.C. Chan

  DOI：10.1016/s0957-4166(98)00339-5

  日期：1998.9

  Chiral diphosphite ligands L1–L3 were prepared by the reaction of (1S,5S,6R)-(cis,trans)-spiro[4.4]nonane-1,6-diol with chlorophosphites. These ligands were tested in the rhodium catalyzed hydroformylation of styrene and enantioselectivities up to 69% were achieved. High regioselectivities (97%) to 2-phenylpropanal and high yields (98%) were obtained under mild reaction conditions. The influence of

  通过（1 S，5 S，6 R）-（顺式，反式）-螺[4.4]壬烷-1,6-二醇与氯代亚磷酸酯的反应制备手性二亚磷酸酯配体L 1 -L 3。在铑催化的苯乙烯的加氢甲酰化反应中测试了这些配体，对映选择性高达69％。在温和的反应条件下，对2-苯基丙醛的区域选择性高（97％），产率高（98％）。还讨论了反应条件的影响。
• PLATINUM COMPLEX AND MEDICAL COMPOUND CONTAINING SAME
  申请人：Unitech Co., Ltd

  公开号：EP2325163A1

  公开（公告）日：2011-05-25

  A new platinum complex which has strong antitumor activity and has effect with smaller doses and a pharmaceutical composition containing the same are provided. A spiro[4,4]nonme-1,6-diamineplatinum(II) complex which is represented by a following general formula (A). (In the formula, X and Y are same or different, and X and Y represent halogen atoms respectively, or X and Y cooperatively represent a divalent residue which is described by a formula (Z) .) The platinum complex has a strong antitumor activity and is efficacious as a therapeutic agent for malignant tumors.

  本研究提供了一种抗肿瘤活性强、剂量较小的新型铂络合物和含有该铂络合物的药物组合物。一种螺[4,4]壬-1,6-二氨铂(II)络合物，由以下通式（A）表示。(式中，X 和 Y 相同或不同，X 和 Y 分别代表卤素原子，或 X 和 Y 共同代表二价残基，二价残基用式（Z）表示）。铂络合物具有很强的抗肿瘤活性，可作为恶性肿瘤的有效治疗剂。
• PLATINUM COMPLEX AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：Arai Hisae

  公开号：US20110152555A1

  公开（公告）日：2011-06-23

  A new platinum complex which has strong antitumor activity and has effect with smaller doses and a pharmaceutical composition containing the same are provided. A spiro[4,4]nonane-1,6-diamineplatinum(II) complex which is represented by a following general formula (A). (In the formula, X and Y are same or different, and X and Y represent halogen atoms respectively, or X and Y cooperatively represent a divalent residue which is described by a formula (Z).) The platinum complex has a strong antitumor activity and is efficacious as a therapeutic agent for malignant tumors.
• US8501977B2
  申请人：——

  公开号：US8501977B2

  公开（公告）日：2013-08-06