2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate | 1190927-36-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate
• CAS: 1190927-36-6
• 化学式: C₁₅H₁₄N₂O₄S₂
• 分子量: 350.419
• InChiKey: SRGFPEXFXKIUFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  115
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  哌啶-4-甲酰胺 、 2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以23%的产率得到1-{2-[4-([1,3]Thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl}piperidine-4-carboxamide
  参考文献：
  名称：

  Azabenzthiazole inhibitors of leukotriene A4 hydrolase

  摘要：

  Previously, benzthiazole containing LTA4H inhibitors were discovered that were potent (1-3), but were associated with the potential for a hERG liability. Utilizing medicinal chemistry first principles (e. g., introducing rigidity, lowering cLogD) a new benzthiazole series was designed, congeners of 1-3, which led to compounds 7a, 7c, 12a-d which exhibited LTA4H IC50 = 3-6 nM and hERG Dofetilide Binding IC50 = 8.9-> >10 mu M. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.036
• 作为产物：
  描述：

  2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethanol 、 甲基磺酸酐 在 4-二甲氨基吡啶 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以91%的产率得到2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yloxy)phenyl]ethyl methanesulfonate
  参考文献：
  名称：

  Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase

  摘要：

  描述了噻唑吡啶-2-氧基苯基和噻唑吡嗪-2-氧基苯基胺化合物，这些化合物可作为LTA4水解酶（LTA4H）调节剂。这些化合物可以用于制备药物组合物，用于调节LTA4H并治疗由LTA4水解酶活性介导的疾病状态、疾病和症状。

  公开号：

  US20090258854A1

文献信息

• Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
  申请人：Bacani Genesis M.

  公开号：US20110159563A1

  公开（公告）日：2011-06-30

  Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.

  本文介绍了一种Thiazolopyridin-2-yloxy-phenyl和thiazolopyrazin-2-yloxy-phenyl胺类化合物，这些化合物可用作LTA4水解酶（LTA4H）调节剂。这些化合物可以用于制备药物组合物和方法，用于调节LTA4H并治疗由LTA4水解酶活性介导的疾病状态、疾患和病情。
• THIAZOLOPYRIDIN-2-YLOXY-PHENYL AND THIAZOLOPYRAZIN-2-YLOXY-PHENYL AMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2268646B1

  公开（公告）日：2013-10-02
• US7939527B2
  申请人：——

  公开号：US7939527B2

  公开（公告）日：2011-05-10
• US8357684B2
  申请人：——

  公开号：US8357684B2

  公开（公告）日：2013-01-22
• [EN] THIAZOLOPYRIDIN-2-YLOXY-PHENYL AND THIAZOLOPYRAZIN-2-YLOXY-PHENYL AMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE<br/>[FR] AMINES DE THIAZOLOPYRIDIN-2-YLOXY-PHENYL ET DE THIAZOLOPYRAZIN-2-YLOXY-PHENYL EN TANT QUE MODULATEURS DE LEUKOTRIENE A4 HYDROLASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2009126806A2

  公开（公告）日：2009-10-15

  Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.