dimethyl 2,6-diisopropyl-4-oxo-2H-pyran-3,5-dicarboxylate | 470717-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: dimethyl 2,6-diisopropyl-4-oxo-2H-pyran-3,5-dicarboxylate
• 英文别名: Dimethyl 4-oxo-2,6-di(propan-2-yl)pyran-3,5-dicarboxylate；dimethyl 4-oxo-2,6-di(propan-2-yl)pyran-3,5-dicarboxylate
• CAS: 470717-48-7
• 化学式: C₁₅H₂₀O₆
• 分子量: 296.32
• InChiKey: WLBCYQBHEWGWFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  dimethyl 2,6-diisopropyl-4-oxo-2H-pyran-3,5-dicarboxylate 在 palladium on activated charcoal lithium aluminium tetrahydride 、 氨 、 氢气 、 potassium carbonate 、 红铝 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 乙醇 、 二氯甲烷 、 丙酮 、 甲苯 为溶剂， 反应 0.5h， 生成 2,6-Diisopropyl-3-(1-hydroxyethyl)-4-(2-hydroxyphenyl)-5-propylpyridine
  参考文献：
  名称：

  Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists

  摘要：

  Optimized substituent patterns in 4-arul-puridine glucagon receptor antagonists were merged to produce highly potent derivatives containing both a 3-[(1R)-hydroxyethyl] and a 2'-hydroxy group. Due to restricted rotation of the phenyl-pyridine bond, these analogues exist as four isomers. A diastereoselective methylcopper reaction as developed to facilitate the synthesis, and single isomers ere isolated with activities in the range IC50 = 10 25 nM. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00736-9
• 作为产物：
  描述：

  1,3-丙酮二羧酸二甲酯 、 异丁酰氯 在 吡啶 、 magnesium bromide 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 0.5h， 以64%的产率得到dimethyl 2,6-diisopropyl-4-oxo-2H-pyran-3,5-dicarboxylate
  参考文献：
  名称：

  Optimization of the 4-aryl group of 4-aryl-pyridine glucagon antagonists: development of an efficient, alternative synthesis

  摘要：

  A narrow structure-activity relationship was established for the 4-aryl group in 4-aryl-pyridine glucagon antagonists, with only small substituents being well-tolerated, and only at the 3'- and 4'-positions. However, substitution with a 2'-hydroxy group gave a ca. 3-fold increase in activity (e.g., 4'-fluoro-2'-hydroxy analogue 33, IC50 = 190 nM). For efficient preparation of 2'-substituted phenylpyridines, a novel synthesis via pyrones and 4-methoxy-pyridines was developed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00143-9