3-Methyl-2-[3-(1-methylquinolin-1-ium-4-yl)-2-phenylprop-2-enylidene]-1,3-benzothiazole | 305802-23-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-Methyl-2-[3-(1-methylquinolin-1-ium-4-yl)-2-phenylprop-2-enylidene]-1,3-benzothiazole
• 英文别名: 3-methyl-2-[3-(1-methylquinolin-1-ium-4-yl)-2-phenylprop-2-enylidene]-1,3-benzothiazole
• CAS: 305802-23-7
• 化学式: C₂₇H₂₃N₂S
• 分子量: 407.559
• InChiKey: IRIDIUNKOFSFNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  32.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(3-甲基-1,3-苯并噻唑-2-亚基)-1-苯基乙酮 、 1,4-二甲基异喹啉-4-甲基苯磺酸盐 在 三氯氧磷 、 三乙胺 作用下， 以 1,2-二氯乙烷 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 3-Methyl-2-[3-(1-methylquinolin-1-ium-4-yl)-2-phenylprop-2-enylidene]-1,3-benzothiazole
  参考文献：
  名称：

  Aza-benzazolium containing cyanine dyes

  摘要：

  描述了包含aza-苯并唑环部分的非对称花青染料，包括通过阳离子侧链取代的花青染料、单体和多聚花青染料、化学活性花青染料以及花青染料偶联物。主题染料在水溶液中稀释时几乎无荧光，但当与核酸聚合物如DNA或RNA结合，或与洗涤剂-蛋白质复合物结合时，则表现出明亮的荧光。描述了用于检测和定量各种样品中的核酸和洗涤剂-蛋白质复合物的一组应用，包括溶液、电泳凝胶、细胞和微生物。

  公开号：

  US06664047B1

文献信息

• Aza-Benzazolium Containing Cyanine Dyes
  申请人：Haugland P. Richard

  公开号：US20080044811A1

  公开（公告）日：2008-02-21

  Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject dyes are virtually non-fluorescent when diluted in aqueous solution, but exhibit bright fluorescence when associated with nucleic acid polymers such as DNA or RNA, or when associated with detergent-complexed proteins. A variety of applications are described for detection and quantitation of nucleic acids and detergent-complexed proteins in a variety of samples, including solutions, electrophoretic gels, cells, and microorganisms.

  本文描述了包含氮杂苯并咪唑环基团的非对称青光菁染料，包括带有阳离子侧链的青光菁染料、单体和二聚体青光菁染料、化学反应性青光菁染料和青光菁染料的共轭物。当在水溶液中稀释时，这些染料几乎不发荧光，但当与核酸聚合物如DNA或RNA结合或与复合物化的蛋白质结合时，表现出明亮的荧光。本文还描述了在各种样品中检测和定量核酸和复合物化蛋白质的各种应用，包括溶液、电泳凝胶、细胞和微生物。
• AZA-BENZAZOLIUM CONTAINING CYANINE DYES
  申请人：HAUGLAND Richard P.

  公开号：US20110217696A1

  公开（公告）日：2011-09-08

  Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject dyes are virtually non-fluorescent when diluted in aqueous solution, but exhibit bright fluorescence when associated with nucleic acid polymers such as DNA or RNA, or when associated with detergent-complexed proteins. A variety of applications are described for detection and quantitation of nucleic acids and detergent-complexed proteins in a variety of samples, including solutions, electrophoretic gels, cells, and microorganisms.

  本文描述了包含氮杂苯并咪唑环基团的非对称青光菁染料，包括带有阳离子侧链的青光菁染料、单体和二聚体青光菁染料、化学反应性青光菁染料以及青光菁染料的共轭物。当在水溶液中稀释时，这些染料几乎不发荧光，但当与核酸聚合物（如DNA或RNA）或与洗涤剂复合的蛋白质结合时，会展现出明亮的荧光。本文描述了在各种样品中检测和定量核酸和洗涤剂复合蛋白质的各种应用，包括溶液、电泳凝胶、细胞和微生物。
• Aza-benzazolium Containing Cyanine Dyes
  申请人：Haugland Richard P.

  公开号：US20120295817A1

  公开（公告）日：2012-11-22

  Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject dyes are virtually non-fluorescent when diluted in aqueous solution, but exhibit bright fluorescence when associated with nucleic acid polymers such as DNA or RNA, or when associated with detergent-complexed proteins. A variety of applications are described for detection and quantitation of nucleic acids and detergent-complexed proteins in a variety of samples, including solutions, electrophoretic gels, cells, and microorganisms.

  本文介绍了包含氮杂苯并咪唑环基团的非对称青烷染料，包括带有阳离子侧链的青烷染料、单体和二聚体青烷染料、化学反应性青烷染料以及青烷染料的共轭物。这些染料在水溶液中稀释后几乎不发荧光，但与核酸聚合物如DNA或RNA或与复合物化蛋白质结合时会产生明亮的荧光。本文描述了在各种样品中检测和定量核酸和复合物化蛋白质的各种应用，包括溶液、电泳凝胶、细胞和微生物。
• Methine-substituted cyanine dye compounds
  申请人：Life Technologies Corporation

  公开号：EP2610315A1

  公开（公告）日：2013-07-03

  Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula (I) where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.

  具有取代的甲基的氰基染料化合物，可作为核酸染色剂，特别是用于 RNA 的荧光染色，包括具有式 (I) 的化合物 其中 R1 是 C1-C6 烷基、磺酰基、羧基烷基或 C1-C6 烷氧基；每个 R2 都独立地选自 H、C1-C6 烷基、C1-C6 烷氧基、熔融苯并、三氟甲基、氨基、磺酰基、羧基和卤素组成的组，可任选地被进一步取代；R3、R4 和 R5 中至少一个是任选被烷基、氨基、氨基烷基、羧基、硝基或卤素取代的烷基、芳基、杂芳基、环状或杂环分子；其余 R3、R4 或 R5 为氢；X 为 S、O 或 Se；D 为取代或未取代的吡啶鎓、喹啉鎓或苯并唑鎓分子。
• [EN] METHINE-SUBSTITUTED CYANINE DYE COMPOUNDS<br/>[FR] COLORANTS DE CYANINE A SUBSTITUTION DE METHINE
  申请人：MOLECULAR PROBES INC

  公开号：WO2005056687A3

  公开（公告）日：2005-11-17