摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

1-苯基苯并三唑-5-胺 | 54883-78-2

中文名称
1-苯基苯并三唑-5-胺
中文别名
——
英文名称
1-phenyl-1H-benzo[1,2,3]triazol-5-ylamine
英文别名
1-phenyl-1H-benzotriazol-5-ylamine;1-Phenyl-1H-benzotriazol-5-ylamin;1-Phenyl-5-amino-benztriazol;5-Amino-1-phenylbenzotriazol;Benzotriazol-5-amine, 1-phenyl-;1-phenylbenzotriazol-5-amine
1-苯基苯并三唑-5-胺化学式
CAS
54883-78-2
化学式
C12H10N4
mdl
——
分子量
210.238
InChiKey
AASWUWVVKDFAMD-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.1
  • 重原子数:
    16
  • 可旋转键数:
    1
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.0
  • 拓扑面积:
    56.7
  • 氢给体数:
    1
  • 氢受体数:
    3

SDS

SDS:caca46247dcd58bc73fc5dda9f59dacb
查看

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-<i>a</i>]pyridine Scaffold: SAR of the Aryloxyaryl Moiety
    作者:Stefano Sainas、Marta Giorgis、Paola Circosta、Giulio Poli、Marta Alberti、Alice Passoni、Valentina Gaidano、Agnese C. Pippione、Nicoletta Vitale、Davide Bonanni、Barbara Rolando、Alessandro Cignetti、Cristina Ramondetti、Alessia Lanno、Davide M. Ferraris、Barbara Canepa、Barbara Buccinnà、Marco Piccinini、Menico Rizzi、Giuseppe Saglio、Salam Al-Karadaghi、Donatella Boschi、Riccardo Miggiano、Tiziano Tuccinardi、Marco L. Lolli
    DOI:10.1021/acs.jmedchem.2c00496
    日期:2022.10.13
    In recent years, human dihydroorotate dehydrogenase inhibitors have been associated with acute myelogenous leukemia as well as studied as potent host targeting antivirals. Starting from MEDS433 (IC50 1.2 nM), we kept improving the structure–activity relationship of this class of compounds characterized by 2-hydroxypyrazolo[1,5-a]pyridine scaffold. Using an in silico/crystallography supported design
    近年来,人类二氢乳清酸脱氢酶抑制剂与急性髓性白血病有关,并被研究为有效的靶向抗病毒药物宿主。从MEDS433(IC 50 1.2 nM)开始,我们不断完善这类以2-羟基吡唑并[1,5- a ]吡啶骨架为特征的化合物的构效关系。使用计算机/晶体学支持的设计,我们鉴定了化合物4 (IC 50 7.2 nM),其特征是存在取代联苯支架的修饰芳氧基芳基部分,对 AML THP1 细胞具有有效的抑制和促分化能力 (EC 50 74 nM),优于布喹那 (EC 50 249 nM),与双嘧达莫合用时效果增强。最后,化合物4对非 AML 细胞以及 MEDS433 具有极低的细胞毒性;它在 AML 异种移植小鼠模型中显示出显着的体内抗白血病活性。
  • NONAQUEOUS ELECTROLYTE AND NONAQUEOUS SECONDARY BATTERY
    申请人:ASAHI KASEI KABUSHIKI KAISHA
    公开号:EP3467930A1
    公开(公告)日:2019-04-10
    The purpose of the present invention is to provide a nonaqueous electrolyte that contains acetonitrile having an excellent balance between viscosity and the dielectric constant and a fluorine-containing inorganic lithium salt, wherein the generation of complex cations comprising a transition metal and acetonitrile is suppressed, excellent load characteristics are exhibited, and increases in internal resistance upon repeated charge/discharge cycles are suppressed; a further purpose of the present invention is to provide a nonaqueous secondary battery. The present invention relates to a nonaqueous electrolyte which contains: a nonaqueous solvent comprising acetonitrile; a fluorine-containing inorganic lithium salt; and a specific nitrogenous cyclic compound typified by benzotriazole.
    本发明的目的是提供一种非电解液,该电解液含有在粘度和介电常数之间具有极佳平衡的乙腈和含无机盐,其中包含过渡属和乙腈的复合阳离子的生成受到抑制,显示出极佳的负载特性,并且在重复充放电循环中内阻的增加受到抑制;本发明的另一个目的是提供一种非二次电池。本发明涉及一种非电解液,其中包含:由乙腈组成的非溶剂;含无机盐;以及以苯并三唑为典型代表的特定含氮环状化合物。
  • Nonaqueous electrolyte and nonaqueous secondary battery
    申请人:Asahi Kasei Kabushiki Kaisha
    公开号:US10756394B2
    公开(公告)日:2020-08-25
    The purpose of the present invention is to provide a nonaqueous electrolyte that contains acetonitrile having an excellent balance between viscosity and the dielectric constant and a fluorine-containing inorganic lithium salt, wherein the generation of complex cations comprising a transition metal and acetonitrile is suppressed, excellent load characteristics are exhibited, and increases in internal resistance upon repeated charge/discharge cycles are suppressed; a further purpose of the present invention is to provide a nonaqueous secondary battery. The present invention relates to a nonaqueous electrolyte which contains: a nonaqueous solvent comprising acetonitrile; a fluorine-containing inorganic lithium salt; and a specific nitrogenous cyclic compound typified by benzotriazole.
    本发明的目的是提供一种非电解液,该电解液含有在粘度和介电常数之间具有极佳平衡的乙腈和含无机盐,其中包含过渡属和乙腈的复合阳离子的生成受到抑制,显示出极佳的负载特性,并且在重复充放电循环中内阻的增加受到抑制;本发明的另一个目的是提供一种非二次电池。本发明涉及一种非电解液,其中包含:由乙腈组成的非溶剂;含无机盐;以及以苯并三唑为典型代表的特定含氮环状化合物。
  • Fries, Justus Liebigs Annalen der Chemie, 1927, vol. 454, p. 204
    作者:Fries
    DOI:——
    日期:——
  • Ullmann, Chemische Berichte, 1898, vol. 31, p. 1698
    作者:Ullmann
    DOI:——
    日期:——
查看更多