5-羟基己醛 | 143956-84-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 5-羟基己醛
• 英文名称: 5-hydroxyhexanal
• CAS: 143956-84-7
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: YRMUTQRWVGDUBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-羟基己醛 在 copper(I) sulfate 、 乙醚 作用下， 生成 bis-(6-methyl-tetrahydro-pyran-2-yl)-ether
  参考文献：
  名称：

  Helferich; Weidenhagen, Chemische Berichte, 1922, vol. 55, p. 3350

  摘要：

  DOI：
• 作为产物：
  描述：

  2H-吡喃,3,4-二氢-2-甲基- 在 水 作用下， 生成 5-羟基己醛
  参考文献：
  名称：

  Colonge,J.; Girantet,A., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1962, vol. 254, p. 498 - 500

  摘要：

  DOI：

文献信息

• [EN] [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINES AS LIGANDS OF THE ANDROGEN RECEPTOR<br/>[FR] [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINES EN TANT QUE LIGANDS DU RÉCEPTEUR DES ANDROGÈNES
  申请人：ASTRAZENECA AB

  公开号：WO2010131022A1

  公开（公告）日：2010-11-18

  The invention concerns bicyclic compounds of Formula (I): wherein, R1, R2, R3, R4, R5, X1, X2, Y, k, m, n and p are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of androgen- receptor associated conditions, particularly prostate cancer.

  本发明涉及式(I)的双环化合物：其中，R1、R2、R3、R4、R5、X1、X2、Y、k、m、n和p如描述中定义。本发明还涉及制备此类化合物的过程、包含它们的药物组合物以及它们在治疗雄激素受体相关状况，尤其是前列腺癌方面的用途。
• CHEMICAL COMPOUNDS 751
  申请人：Bradbury Robert Hugh

  公开号：US20100292222A1

  公开（公告）日：2010-11-18

  The invention concerns bicyclic compounds of Formula (I) wherein, R 1 , R 2 , R 3 , R 4 , R 5 , X 1 , X 2 , Y, k, m, n and p are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of androgen-receptor associated conditions, particularly prostate cancer.

  本发明涉及式（I）的双环化合物，其中R1、R2、R3、R4、R5、X1、X2、Y、k、m、n和p如描述中所定义。本发明还涉及制备这种化合物的方法、包含它们的制药组合物以及它们在治疗与雄激素受体相关的疾病，特别是前列腺癌方面的用途。
• FUSED HETEROAROMATIC CYCLOPENTENE DERIVATIVE HAVING ENDOTHELIN-ANTAGONIST ACTIVITY
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0714897A1

  公开（公告）日：1996-06-05

  A cyclopentene derivative represented by general formula (I) and a pharmaceutically acceptable salt thereof: wherein Ar¹ and Ar² represent each independently phenyl, thienyl, pyridyl, indolyl, benzofuranyl or dihydrobenzofuranyl; A represents a group that is combined with the adjacent carbon-carbon double bond to form a 5-or 6-membered heteroaromatic ring containing one to four heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; and Y represents -CO-R⁴, SO₃H, PO₃H₂, tetrazol-5-yl, 2-oxo-3H-1,2,3,5-oxathiadiazol-4-yl or 5-oxo-4H-1,2,4-oxadiazol-3-yl.

  通式 (I) 所代表的环戊烯衍生物及其药学上可接受的盐：其中 Ar¹ 和 Ar² 各自独立地代表苯基、噻吩基、吡啶基、吲哚基、苯并呋喃基或二氢苯并呋喃基；A 代表一个基团，该基团与相邻的碳碳双键结合形成一个 5 或 6 元杂芳环，该环含有一至四个杂原子，这些杂原子选自由氮、氧和硫组成的组；Y 代表-CO-R⁴、SO₃H、PO₃H₂、四唑-5-基、2-氧代-3H-1,2,3,5-噁二唑-4-基或 5-氧代-4H-1,2,4-噁二唑-3-基。
• PROCESS FOR PRODUCING ALIPHATIC ALDEHYDIC ACID AND/OR ALIPHATIC DICARBOXYLIC ACID AND CATALYST FOR THE PRODUCTION
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP1142858A1

  公开（公告）日：2001-10-10

  A process for producing an aliphatic aldehydic acid (e.g., adipaldehydic acid) and/or aliphatic dicarboxylic acid (e.g., adipic acid) which comprises oxidizing a cyclic ketone (e.g., cyclohexanone) with molecular oxygen in the presence of an immobilized catalyst which comprises a composite comprising a support and supported thereon at least one metallic element belonging to Groups 4 to 11 of the Periodic Table and has an acid amount of 0.06 mmol or larger per gram of the support.

  一种生产脂肪族醛酸（如己二酸）和/或脂肪族二羧酸（如己二酸）的工艺，该工艺包括在固定催化剂存在下用分子氧氧化环酮（如环己酮），固定催化剂包括一种复合材料，该复合材料由载体组成，载体上支撑有至少一种属于元素周期表第4至11族的金属元素，每克载体的酸量为0.06毫摩尔或更大。
• Method for removal of unwanted organism from the human body and a treatment for removal of unwanted organism from the human body
  申请人：Vanmoor Arthur

  公开号：US20060116353A1

  公开（公告）日：2006-06-01

  A method and treatment for removing an unwanted living organism from a person includes administering topically to the person an effective amount of a solution including a pyrethrin compound and piperonyl butoxide. The term “pyrethrin compound” includes pyrethrin, cinerin, and allethrin. A carrier formulation can be added to said piperonyl butoxide and said pyrethrin compound to form a cream, an emulsion, a lotion, an ointment, or a paste. The carrier formulation can be based on petrolatum, mineral oil, vegetable oil, denatured ethanol, or isopropyl alcohol. The method and treatment can be applied for treating cuts and bruises, reducing body odor, repelling insects, and diminishing parasites.

  一种清除人体内不想要的生物体的方法和治疗方法包括向人局部施用有效量的溶液，该溶液包括除虫菊酯化合物和胡椒基丁醚。术语 "除虫菊酯化合物 "包括除虫菊酯、西尼林和艾菊酯。可向所述除虫菊酯化合物和丁氧化胡椒中添加载体制剂，以形成霜剂、乳剂、洗剂、软膏或糊剂。载体制剂可以基于凡士林油、矿物油、植物油、变性乙醇或异丙醇。该方法和疗法可用于治疗割伤和瘀伤、减少体味、驱虫和减少寄生虫。