2-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-1-(4-methoxy-phenyl)-ethanone | 51254-38-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-1-(4-methoxy-phenyl)-ethanone
• 英文别名: 1-(p-Methoxyacetophenonyl)-hydrocotarnin；2-(4-Methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-1-(4-methoxyphenyl)ethanone；2-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-1-(4-methoxyphenyl)ethanone
• CAS: 51254-38-7
• 化学式: C₂₁H₂₃NO₅
• mdl: MFCD02115528
• 分子量: 369.417
• InChiKey: OWDPAOQLSAOHNV-UHFFFAOYSA-N

物化性质

• 沸点：
  515.9±50.0 °C(Predicted)
• 密度：
  1.217±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  57.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-1-(4-methoxy-phenyl)-ethanone 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 2-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-1-(4-methoxy-phenyl)-ethanol
  参考文献：
  名称：

  Goeber; Bauer; Pfeifer, Pharmazie, 1973, vol. 28, # 5, p. 310 - 317

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-二氧杂环戊烯并[4,5-g]异喹啉-5-醇,5,6,7,8-四氢-4-甲氧基-6-甲基- 在 sodium amalgam 作用下， 以 甲醇 、 乙醚 、 水 为溶剂， 生成 2-(4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-1-(4-methoxy-phenyl)-ethanone
  参考文献：
  名称：

  Goeber; Bauer; Pfeifer, Pharmazie, 1973, vol. 28, # 4, p. 221 - 232

  摘要：

  DOI：

文献信息

• NOVEL ANALGESIC THAT BINDS FILAMIN A
  申请人：Barbier Lindsay Burns

  公开号：US20100280061A1

  公开（公告）日：2010-11-04

  A compound, composition and method are disclosed that can bind to FLNA and provide analgesia. A contemplated compound has a structure that corresponds to Formula I, wherein R 1 and R 2 are substituents on W that is a ring structure, R 3 and R 4 are substituents on the depicted nitrogen atom, m, n and the dotted lines are all defined within.
• ALZHEIMER'S DISEASE ASSAY IN A LIVING PATIENT
  申请人：WANG HOAU-YAN

  公开号：US20140017698A1

  公开（公告）日：2014-01-16

  An assay for Alzheimer's disease (AD) pathology in a living patient is disclosed wherein an amount of α7nAChR or TLR4 in a FLNA-captured protein complex or α7nAChR in an Aβ-captured protein complex or α7nAChR-FLNA, or TLR4-FLNA and/or α7nAChR-Aβ 42 complex present as a protein-protein complex in a sample is compared to the amount in a standard sample from a person free of AD pathology. An amount greater than in the standard sample indicates AD pathology. Also disclosed is an assay predictive of prognosis for treatment with a medicament in which the amount of an above protein or protein complex is compared to an amount in the presence of a medicament that binds to a FLNA pentapeptide and contains at least four pharmacophores of FIGS. 7 - 12 . An amount of protein or protein complex determined in the presence of medicament that is less than the first amount indicates a favorable treatment prognosis.
• US9354223B2
  申请人：——

  公开号：US9354223B2

  公开（公告）日：2016-05-31
• Goeber; Bauer; Pfeifer, Pharmazie, 1973, vol. 28, # 4, p. 221 - 232
  作者：Goeber、Bauer、Pfeifer、Dube、Engelhardt、Jancke

  DOI：——

  日期：——
• Goeber; Bauer; Pfeifer, Pharmazie, 1973, vol. 28, # 5, p. 310 - 317
  作者：Goeber、Bauer、Pfeifer、Dube、Engelhardt、Jancke

  DOI：——

  日期：——