(N¹-(2-aminoethyl)-N²-(7-trifluoromethyl)quinolin-4-yl)ethane-1,2-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (N¹-(2-aminoethyl)-N²-(7-trifluoromethyl)quinolin-4-yl)ethane-1,2-diamine
• 英文别名: N-(2-Aminoethyl)-N'-[7-(trifluoromethyl)quinoline-4-yl]ethane-1,2-diamine；N'-[2-[[7-(trifluoromethyl)quinolin-4-yl]amino]ethyl]ethane-1,2-diamine
• 化学式: C₁₄H₁₇F₃N₄
• 分子量: 298.311
• InChiKey: FXYIHSZDPJMZHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  63
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-氯-7-三氟甲基喹啉 、 二乙烯三胺 反应 3.0h， 以75%的产率得到(N¹-(2-aminoethyl)-N²-(7-trifluoromethyl)quinolin-4-yl)ethane-1,2-diamine
  参考文献：
  名称：

  Synthesis and evaluation of the anti-nociceptive and anti-inflammatory activity of 4-aminoquinoline derivatives

  摘要：

  In this paper, we describe the synthesis and pharmacological evaluation of a series of 4-aminoquinolines. The compounds were characterised and tested in models of pain and inflammation, using the writhing test with acetic acid, formalin test, peritonitis test by zymosan and arthritis test with Freund's adjuvant complete assay. The results revealed that all of the 4-aminoquinolines that were prepared promoted anti-nociceptive activity as well as acute and chronic anti-inflammatory effects, with marked activity in the derivates labelled with BAQ and 7-CF3-MAQ. After 7 days of treatment, 7-CF3-MAQ did not induce significant hepatotoxicity, gastrotoxicity or nephrotoxicity. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.06.029

文献信息

• Synthesis and evaluation of the anti-nociceptive and anti-inflammatory activity of 4-aminoquinoline derivatives
  作者：Raquel de Meneses Santos、Pooline Rocha Barros、Janaína Heberle Bortoluzzi、Mario Roberto Meneghetti、Yolanda Karla Cupertino da Silva、Amanda Evelyn da Silva、Mariana da Silva Santos、Magna Suzana Alexandre-Moreira

  DOI：10.1016/j.bmc.2015.06.029

  日期：2015.8

  In this paper, we describe the synthesis and pharmacological evaluation of a series of 4-aminoquinolines. The compounds were characterised and tested in models of pain and inflammation, using the writhing test with acetic acid, formalin test, peritonitis test by zymosan and arthritis test with Freund's adjuvant complete assay. The results revealed that all of the 4-aminoquinolines that were prepared promoted anti-nociceptive activity as well as acute and chronic anti-inflammatory effects, with marked activity in the derivates labelled with BAQ and 7-CF3-MAQ. After 7 days of treatment, 7-CF3-MAQ did not induce significant hepatotoxicity, gastrotoxicity or nephrotoxicity. (C) 2015 Elsevier Ltd. All rights reserved.