2,6-双[(2-羟基苯基)甲基]苯酚 | 2677-32-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 中文名称: 2,6-双[(2-羟基苯基)甲基]苯酚
• 英文名称: 2,6-Bis-(2-hydroxy-benzyl)-phenol
• 英文别名: 2,6-bis-(2-hydroxybenzyl)-phenol；2,6-Disalicyl-phenol；2,2'-[(2-Hydroxy-1,3-phenylene)bis(methylene)]diphenol；2,6-bis[(2-hydroxyphenyl)methyl]phenol
• CAS: 2677-32-9
• 化学式: C₂₀H₁₈O₃
• 分子量: 306.361
• InChiKey: IVHIQAKUMAQRAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-双[(2-羟基苯基)甲基]苯酚 在 氢氧化钾 、 caesium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 水 、 丙酮 为溶剂， 生成 triphenoxyacetic acid
  参考文献：
  名称：

  Chloride Transport Across Lipid Bilayers and Transmembrane Potential Induction by an Oligophenoxyacetamide

  摘要：

  This contribution describes the discovery and properties of a synthetic, low-molecular weight compound that transports Cl- across bilayer membranes. Such compounds have potential as therapeutics for cystic fibrosis and cancer. The H+/Cl- co-transport activities of acyclic tetrabutylamides 1-6 were compared by using a pH-stat assay with synthetic EYPC liposomes. The ion transport activity of the most active compound, trimer 3, was an order of magnitude greater than that of calix[4]arene tetrabutylamide C1 a macrocycle known to function as a synthetic ion channel. Trimer 3 has an unprecedented function for a synthetic compound, as it induces a stable potential in liposomes experiencing a transmembrane Cl-/SO42- gradient. Data from both pH-stat and 35Cl NMR experiments indicate that 3 co-transports H+/Cl-. Although 3 transports both Cl- and H+ the overall process is not electrically silent. Thus, trimer 3 induces a stable potential in LUVs due to a transmembrane anionic gradient. The ability of trimer 3 to transport Cl-, to maintain a transmembrane potential, along with its high activity at uM concentrations, its low molecular weight, and its simple preparation, make this compound a valuable lead in drug development for diseases caused by Cl- transport malfunction.

  DOI：

  10.1021/ja029372t
• 作为产物：
  描述：

  4-溴-2,6-双[(5-溴-2-羟基苯基)甲基]苯酚 在 氢氧化钾 、 锌 作用下， 反应 4.0h， 以88%的产率得到2,6-双[(2-羟基苯基)甲基]苯酚
  参考文献：
  名称：

  多官能芳环体系的合成。磷脂，阿霉素，隐孢菌素和土霉素的结构类似物

  摘要：

  描述了标题化合物的合成。发现所制备的某些化合物在体外对多种病原微生物具有活性。

  DOI：

  10.1002/hlca.19810640224

文献信息

• Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same
  申请人：Davis T. Jeffery

  公开号：US20050009921A1

  公开（公告）日：2005-01-13

  A compound containing at least two aromatic rings covalently bonded together, with each aromatic ring containing at least one oxyacetamide-based side chain, the compound being capable of forming a chloride ion channel across a lipid bilayer, and transporting chloride ion across the lipid bilayer.

  含有至少两个芳香环的化合物，这些芳香环以共价键结合在一起，每个芳香环至少含有一个氧乙酰胺基侧链，该化合物能够在脂质双分子层上形成氯离子通道，并在脂质双分子层上运输氯离子。
• POLYCYCLIC AROMATIC HYDROCARBON COMPOUNDS CONTAINING AN S ATOM OR S(=O)2 GROUP IN THEIR BASIC STRUCTURE
  申请人：Sicpa Holding SA

  公开号：US20130127150A1

  公开（公告）日：2013-05-23

  Polycyclic aromatic hydrocarbon compounds having an S atom or S(═O) 2 moiety incorporated in their basic polycyclic structure that can have a nitrogen-containing heterocycloaliphatic group and/or a substituted or unsubstituted phenoxy group and/or a polymeric moiety bonded to the polycyclic structure and to compositions such as, e.g., printing inks which comprise these polycyclic aromatic hydrocarbons as colorants.

  在其基本多环结构中具有S原子或S(═O)2基团的多环芳烃化合物，可以具有含氮杂环脂肪族基团和/或取代或未取代的苯氧基团和/或与多环结构结合的聚合基团，以及诸如印刷油墨等组合物，这些组合物包括这些多环芳烃作为着色剂。
• Solvent-free synthesis of trisphenols as starting precursors for the synthesis of calix[4]arenes using sulfonated multi-walled carbon nanotubes
  作者：Reza Fareghi-Alamdari、Mohsen Golestanzadeh、Negar Zekri

  DOI：10.1039/c5nj03136b

  日期：——

  enols (BMP) (6 examples) is reported using sulfonated multi-walled carbon nanotubes (SO3H@MWCNTs) under solvent-free conditions as starting precursors for the synthesis of macrocyclic molecules of calix[4]arenes. The new protocol provides a series of trisphenol derivatives (21 examples) in high yields (up to 94%) and relatively short reaction times (15–120 min). Also, direct synthesis of calix[4]arenes

  据报道，在无溶剂条件下使用磺化多壁碳纳米管（SO 3 H @ MWCNTs）作为苯酚衍生物（12种底物）与2,6-双（羟甲基）苯酚（BMP）的缩合（6个实例）用于合成杯[4]芳烃的大环分子。该新方案以高收率（高达94％）和相对较短的反应时间（15-120分钟）提供了一系列三酚衍生物（21个实例）。另外，已有报道通过使用催化剂由不同的三酚直接合成杯[4]芳烃（5个实例）。此外，合成的杯[4]芳烃是通过一锅法从简单易得的原料（如p）获得的。-甲酚合成5,11,17,23-四甲基杯[4]芳烃-25,26,27,28-四醇。同样，在此过程中，SO 3 H @ MWCNTs可以以几乎一致的效率重复使用七次，并且可以通过简单的过滤回收。
• COMPOUND FOR FORMING ORGANIC FILM, COMPOSITION FOR FORMING ORGANIC FILM, METHOD FOR FORMING ORGANIC FILM, AND PATTERNING PROCESS
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20170184968A1

  公开（公告）日：2017-06-29

  A compound for forming an organic film shown by the formula (1A), R—(—X) m1 (1A) wherein R represents a single bond or an organic group having 1 to 50 carbon atoms; X represents a group shown by formula (1B); and ml represents an integer satisfying 2≦m1≦10, wherein X 2 represents a divalent organic group having 1 to 10 carbon atoms; n1 represents 0 or 1; n2 represents 1 or 2; X 3 represents a group shown by the formula (1C); and n5 represents 0, 1, or 2, wherein R 10 represents a hydrogen atom or a saturated or unsaturated hydrocarbon group having 1 to 10 carbon atoms, wherein a hydrogen atom of the benzene ring in formula (1C) may be substituted with a methyl group or methoxy group. This compound for forming an organic film can provide organic film composition having good dry etching resistance, heat resistance to 400° C. or higher, high filling and planarizing properties.

  一种用于形成有机薄膜的化合物，其化学式为(1A)，R—(—X)m1(1A)，其中R代表一个单键或具有1至50个碳原子的有机基团；X代表化学式(1B)所示的基团；m1代表满足2≦m1≦10的整数，其中X2代表具有1至10个碳原子的二价有机基团；n1代表0或1；n2代表1或2；X3代表化学式(1C)所示的基团；n5代表0、1或2，其中R10代表氢原子或具有1至10个碳原子的饱和或不饱和碳氢基团，化学式(1C)中苯环的氢原子可能被甲基基团或甲氧基取代。这种用于形成有机薄膜的化合物可以提供具有良好干法刻蚀抗性、耐高温至400°C或更高、高填充和平整化性能的有机薄膜组合物。
• [EN] IMPROVED MANUFACTURING PROCESS FOR DIHYDROXYDIPHENYLMETHANE WITH HIGH SELECTIVITY FOR 2,4'- DIHYDROXYDIPHENYLMETHANE<br/>[FR] PROCÉDÉ DE FABRICATION AMÉLIORÉ POUR LA PRODUCTION DE DIHYDROXYDIPHÉNYLMÉTHANE CONTENANT UNE HAUTE SÉLECTIVITÉ POUR LA PRODUCTION DE 2,4'- DIHYDROXYDIPHÉNYLMÉTHANE
  申请人：ADITYA BIRLA CHEMICALS THAILAND LTD

  公开号：WO2015041614A1

  公开（公告）日：2015-03-26

  The invention relates to an improved manufacturing process for the preparation of high 2, 4 '-dihydroxydiphenylmethane, by a process involving reaction of phenol and formaldehyde, in the presence of an inorganic polyprotic acid. According to this process, the reaction conditions are selected to favour a high yield of dihydroxydiphenylmethane, with a relatively high concentration of the 2,4'-isomer, by using a relatively low molar excess of phenol than conventional methods.

  本发明涉及一种改进的制造高2,4'-二羟基二苯甲烷的方法，该方法涉及苯酚和甲醛在无机多元酸存在下反应的过程。根据该方法，选择反应条件以促进高产率的二羟基二苯甲烷，并使用相对较低的苯酚摩尔过量，以获得相对较高浓度的2,4'-异构体，与传统方法相比。