溴敌隆 | 28772-56-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 中文名称: 溴敌隆
• 中文别名: 3-{3-[4'-溴-(1,1'-联苯)-4-基]-3-羟基-1-苯基丙基}4-羟基-2H-1-苯并吡喃-2-酮；3-[3-(4-溴联苯基)-3-羟基-1-苯基丙基]-4-羟基香豆素；3-(3-(4-溴-(1,1-联苯)-4-基)-3-羟基-1-苯丙基)-4-羟基-2H-1-苯并吡喃-2-酮；3-(4'-羟基-3-香豆素基)-3-苯基-1-对溴联苯基丙醇；溴特隆；乐万通；3-[3-(4-溴联苯基)-3-羟基-1-苯基丙基]-4-羟基-2H-1-苯并吡喃-2-酮
• 英文名称: bromadiolone
• 英文别名: 3-[3-(4′-hydroxy-3′-coumarinyl)-3-phenyl]-1-(4′-bromo-4′-biphenyl)propan-1-ol；bromodiolone；bromone；3-{3-[4'-bromo(1,1'-biphenyl)-4-yl]-3-hydroxy-1-phenylpropyl}-4-hydroxy-2-benzopyrone；bromodialone；3-[3-[4-(4-bromophenyl)phenyl]-3-hydroxy-1-phenylpropyl]-4-hydroxychromen-2-one
• CAS: 28772-56-7
• 化学式: C₃₀H₂₃BrO₄
• mdl: MFCD00128053
• 分子量: 527.414
• InChiKey: OWNRRUFOJXFKCU-UHFFFAOYSA-N

物化性质

• 稳定性/保质期：

  如果按照规格正确使用和储存，则不会分解，也未有已知的危险反应。该物质对皮肤无明显刺激作用，但会对眼睛造成刺激。

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

ADMET

代谢

这项研究的目标是评估体外条件下华法林、氯法齐酮和溴鼠灵在瘤胃中的降解速率和程度，并确定每种抗凝血灭鼠剂在成年绵羊中的口服生物利用度以及临床和止血效果。瘤胃液样本与每种抗凝血剂一起培养，以评估24小时内瘤胃降解的动力学。为了确定抗凝血剂在血浆中的动力学，3只特塞尔绵羊中的每只绵羊在2个月的间隔内通过静脉注射或瘤胃植入插管接受每种抗凝血剂（每只绵羊暴露于3种灭鼠剂）。在处理后的240到360小时期间的不同时间点，测量凝血酶原时间（PT），评估血浆中抗凝血剂的浓度，并监测灭鼠剂中毒的临床症状。通过高效液相色谱法确定血浆和瘤胃提取物中的抗凝血剂浓度。在瘤胃提取物中，抗凝血剂在24小时内的降解非常轻微（小于15%）。在活体中，华法林、氯法齐酮和溴鼠灵的口服生物利用度分别估计为79%，92%和88%。尽管氯法齐酮和溴鼠灵处理后最大PT为80秒，但未检测到中毒的临床症状；PT在2周内恢复到基线值。在绵羊中，华法林、氯法齐酮和溴鼠灵在瘤胃中未发生降解，但口服给药后的生物利用度很高；这些化合物在绵羊和其他哺乳动物中的动力学非常相似。这些数据表明，反刍动物对这些抗凝血灭鼠剂的不易感性不能通过瘤胃降解或这些抗凝血剂的特定毒物动力学来解释。

/The goal of this study is/ to assess the rate and extent of ruminal degradation of warfarin, chlorophacinone, and bromadiolone in vitro and determine the oral availability and clinical and hemostatic effects of each anticoagulant rodenticide in adult sheep... Samples of ruminal fluid were incubated with each of the anticoagulants to assess the kinetics of ruminal degradation over 24 hours. To determine the plasma kinetics of the anticoagulants, each /of 3 Texel/ sheep received each of the anticoagulants IV or via a rumen implanted cannula at 2-month intervals (3 rodenticide exposures/sheep). At intervals during a 240- to 360- hour period after treatment, prothrombin time (PT) was measured, plasma anticoagulant concentration was assessed, and clinical signs of rodenticide poisoning were monitored. In plasma and rumen extracts, anticoagulant concentrations were determined via high-performance liquid chromatography. In the rumen extracts, anticoagulants were slightly degraded (< 15%) over 24 hours. In vivo, oral availability of warfarin, chlorophacinone, and bromadiolone was estimated at 79%, 92%, and 88%, respectively. Although maximum PT was 80 seconds after chlorophacinone and bromadiolone treatments, no clinical signs of toxicosis were detected; PT returned to baseline values within 2 weeks. In sheep, warfarin, chlorophacinone, and bromadiolone were not degraded in the rumen but their bioavailabilities were high after oral administration; the kinetics of these compounds in sheep and other mammals are quite similar. These data suggest that the lack of susceptibility of ruminants to these anticoagulant rodenticides cannot be explained by either ruminal degradation or the specific toxicokinetics of these anticoagulants.

来源:Hazardous Substances Data Bank (HSDB)

代谢

华法林是一种广泛用于治疗和预防血栓、慢性房颤、机械瓣膜、肺栓塞和扩张型心肌病的抗凝剂。它无味无色，曾被用作毒药，并且仍然作为针对老鼠的杀虫剂销售。几种长效华法林衍生物——超级华法林抗凝剂，如溴敌隆、二苯恶嗪、氯鼠灵、溴敌鼠隆等，被用作杀虫剂，并可以产生深刻和持久的抗凝作用。有几个因素会增加华法林中毒的风险。然而，细胞色素P450基因的多态性和药物相互作用是导致毒性并发症风险的主要原因。每个人对有毒物质的易感程度都是独特的。大多数有毒物质的毒性解释和健康风险是一个不确定性的主题。个体基因决定的低代谢能力可以显著改变毒素和代谢物水平，这与正常预期不同，这对于治疗指数狭窄的药物（如华法林）至关重要。个性化的解释方法有潜力消除毒性案例中的一些科学不确定性。

Warfarin is a widely used anticoagulant in the treatment and prevention of thrombosis, in the treatment for chronic atrial fibrillation, mechanical valves, pulmonary embolism, and dilated cardiomyopathy. It is tasteless and colorless, was used as a poison, and is still marketed as a pesticide against rats and mice. Several long-acting warfarin derivatives-superwarfarin anticoagulants-such as brodifacoum, diphenadione, chlorophacinone, bromadiolone, are used as pesticides and can produce profound and prolonged anticoagulation. Several factors increase the risk of warfarin toxicity. However, polymorphisms in cytochrome P450 genes and drug interactions account for most of the risk for toxicity complications. Each person is unique in their degree of susceptibility to toxic agents. The toxicity interpretation and the health risk of most toxic substances are a subject of uncertainty. Genetically determined low metabolic capacity in an individual can dramatically alter the toxin and metabolite levels from those normally expected, which is crucial for drugs with a narrow therapeutic index, like warfarin. Personalized approaches in interpretation have the potential to remove some of the scientific uncertainties in toxicity cases.

来源:Hazardous Substances Data Bank (HSDB)

代谢

在挪威鼠（Rattus norvegicus (Berk.)）中，抗凝剂耐药性被认为是由VKORC1基因的突变赋予的，该基因编码抗凝剂灭鼠剂的目标蛋白。其他因素，例如药物代谢动力学，也可能有助于耐药性。为了研究药物代谢动力学在雄性和雌性大鼠对溴敌隆耐药性中的作用，从丹麦溴敌隆耐药大鼠株（具有Y139C-VKORC1突变）的七个细胞色素P450基因的肝脏表达谱与易感株的表达谱进行了比较。在溴敌隆存在的情况下，Cyp2e1、Cyp2c13、Cyp3a2和Cyp3a3基因在耐药雌性大鼠中的表达显著上调，而Cyp2c12基因的表达与易感雌性相比受到抑制。与易感雄性相比，耐药雄性显示出Cyp2a1、Cyp2e1、Cyp3a2和Cyp3a3基因的显著过表达。在接触溴敌隆时，雌性的Cyp2e1表达高于雄性，这可能是雌性大鼠通常对抗凝剂比雄性大鼠更耐受的原因。结果表明，丹麦株挪威大鼠的溴敌隆耐药性涉及细胞色素P450-2e1、-3a2和-3a3催化的抗凝剂代谢增强。这种基于药物代谢动力学的溴敌隆耐药性在一定程度上具有性别差异，因为雌性耐药还涉及细胞色素P450-2c13的过表达和P450-2c12的抑制，而雄性耐药似乎涉及P450-2a1的过表达。

Anticoagulant resistance in Norway rats, Rattus norvegicus (Berk.), has been suggested to be conferred by mutations in the VKORC1 gene, encoding the target protein of anticoagulant rodenticides. Other factors, e.g. pharmacokinetics, may also contribute to resistance, however. To examine the involvement of pharmacokinetics in bromadiolone resistance in male and female rats, liver expression profiles of seven cytochrome P450 genes from a Danish bromadiolone-resistant rat strain (with an Y139C-VKORC1 mutation) were compared with profiles from an anticoagulant-susceptible strain. In the presence of bromadiolone, the Cyp2e1, Cyp2c13, Cyp3a2 and Cyp3a3 genes were significantly overexpressed, while Cyp2c12 expression was suppressed in resistant female rats compared with susceptible females. Relative to susceptible males, resistant males showed significant overexpression of the Cyp2a1, Cyp2e1, Cyp3a2 and Cyp3a3 genes. On exposure to bromadiolone, females had higher Cyp2e1 expression than males, which possibly explains why female rats are generally more tolerant to anticoagulants than male rats. Results suggest that bromadiolone resistance in a Danish strain of Norway rats involves enhanced anticoagulant metabolism catalyzed by cytochrome P450-2e1, -3a2 and -3a3. This pharmacokinetically based bromadiolone resistance is to some extent sex differentiated, as female resistance furthermore seems to involve overexpression of cytochrome P450-2c13 and suppression of P450-2c12, whereas male resistance appears to involve P450-2a1 overexpression.

来源:Hazardous Substances Data Bank (HSDB)

代谢

Bromadiolone, brodifacoum 和 coumatetralyl 也同样在大鼠体内发现，作为未改变的母化合物。

Bromadiolone, brodifacoum and coumatetralyl were also found in rats as unchanged parent compounds... .

来源:Hazardous Substances Data Bank (HSDB)

代谢

长效化合物通过肝脏细胞色素P-450同种物（例如，CYP3A4）进行代谢。/长效杀鼠剂/

Long-acting compounds are metabolized by hepatic cytochrome P-450 isozymes (e.g., CYP3A4). /Long-Acting Rodenticides/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

非甾体抗炎药布洛芬和苯丁唑酮在大鼠中增强了溴鼠隆和溴敌隆的抗凝作用。

The non-steroid anti-inflammatory drugs ibuprofen and phenylbutazone potentiated the anticoagulant effects of brodifacoum and bromadiolone in rats.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

以下药物可能会增加对香豆素或香豆素衍生物的反应：酒精（急性中毒）、别嘌醇、氨基水杨酸、胺碘酮、雄激素类固醇、水合氯醛、氯霉素、西咪替丁、氯贝特、复方新诺明、达那唑、右甲状腺素钠、二氮嗪、二氟尼柳、双硫仑、红霉素、依他尼酸、非诺洛芬钙、胰高血糖素、布洛芬、吲哚美辛、流感病毒疫苗、异烟肼、米索前列醇、甲芬那酸、甲巯咪唑、甲硝唑、咪康唑、萘啶酸、新霉素（口服）、己酮可可碱、保泰松、丙氧酚、丙硫氧嘧啶、奎尼丁、奎宁、水杨酸盐、链激酶、磺吡酮、磺胺类药物、舒林酸、四环素、噻嗪类利尿剂、甲状腺药物、三环类抗抑郁药、尿激酶、维生素E。/香豆素和香豆素衍生物/

The following drugs ... may increase ... response to coumarin or indandione derivatives: alcohol (acute intoxication), allopurinol, aminosalicylic acid, amiodarone, anabolic steroids, chloral hydrate, chloramphenicol, cimetidine, clofibrate, co-trimoxazole, danazol, dextrothyroxine sodium, diazoxide, diflunisal, disulfiram, erythromycin, ethacrynic acid, fenoprofen calcium, glucagon, ibuprofen, indomethacin, influenza virus vaccine, isoniazid, meclofenamate, mefenamic acid, methylthiouracil, metronidazole, miconazole, nalidixic acid, neomycin (oral), pentoxifylline, phenylbutazone, propoxyphene, propylthiouracil, quinidine, quinine, salicylates, streptokinase, sulfinpyrazone, sulfonamides, sulindac, tetracyclines, thiazides, thyroid drugs, tricyclic antidepressants, urokinase, vitamin E. /Coumarin and indandione derivatives/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

以下是可能会减少对香豆素或香豆素衍生物反应的药物：酒精（慢性酒精中毒）、巴比妥类药物、卡马西平、皮质类固醇、促皮质激素、乙氯戊烯醇、 glutethimide、灰黄霉素、巯嘌呤、美沙酮、含有雌激素的口服避孕药、利福平、螺内酯、维生素K。/香豆素和香豆素衍生物/

The following drugs ... may ... decrease ... response to coumarin or indandione derivatives: alcohol (chronic alcoholism), barbiturates, carbamazepine, corticosteroids, corticotropin, ethchlorvynol, glutethimide, griseofulvin, mercaptopurine, methaqualone, oral contraceptives containing estrogen, rifampin, spironolactone, vitamin K. /Coumarin and indandione derivatives/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

兽医：受损的毛细血管无法修复，但其他措施可能挽救动物的生命。应尽量减少约束和操作。在约束时，使用镇静剂或安眠药可能会有所帮助，以减少活动，从而降低组织的氧需求。可以给予氧气，但不建议手动按压胸部。呼吸困难可以通过胸腔穿刺缓解。应通过输血（20毫升/千克，一半快速注射）提供凝血因子。华法林应通过缓慢静脉注射维生素K1来拮抗。狗和猫给予5毫克/千克。这个剂量重复两天，使用肌内注射途径。大型动物给予0.5至1毫克/千克，并且每天口服维生素K1，持续4-6天。维生素不会产生突然的戏剧性治愈效果；但随着凝血因子的开始合成，出血倾向将逐渐减轻... 甲萘醌（维生素K3）不如维生素K1有效... 由于局部出血导致的残余缺陷，如跛行或中枢神经系统症状，随着外渗血液的逐渐吸收可能会消失。肝损伤可以通过肝细胞的再生来补偿。/华法林/

VETERINARY: Injured capillaries cannot be mended, but other measures may save the animal. Restraint & handling should be minimized. A sedative or tranquilizer may be of assistance in restraint, calming ... and reducing locomotion, thus decr tissue oxygen demand. Oxygen may be given, but manual pumping of chest is not advisable. Dyspnea may be relieved by thoracentesis. Clotting factors should be provided in form of blood transfusion (20 mL/kg, 1/2 injected quickly). Warfarin should be antagonized with slow iv injection of vitamin K1. Dogs and cats are given 5 mg/kg. This dose is repeated for 2 more days, using im route. Larger animals are given 0.5 to 1 mg/kg, and oral vitamin K1 should be admin daily for 4-6 days. The vitamin will not evoke a sudden dramatic cure; but bleeding tendency will gradually abate as clotting factors begin to be synthesized ... Menadione (vitamin K3) is not as effective as vitamin K1 ... Residual defects such as lameness or CNS signs from localized hemorrhages may disappear with gradual resorption of extravasated blood. Liver damage may be compensated by regeneration of hepatic cells. /Warfarin/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

对于自杀性大量摄入，如果不确定摄入的诱饵量或患者的总体健康状况，口服叶绿素（维生素K1）可以防止这些杀鼠剂的抗凝作用，对患者基本上没有风险。在健康儿童意外摄入，仅涉及尝一下或单独吞咽的情况下，不需要医疗治疗，但应观察儿童是否有出血和瘀伤。如果可能摄入了更大剂量，应在24小时和48小时监测凝血酶原时间（PT），并在PT升高或出现出血的临床症状时开始叶绿素治疗。注意：特别需要叶绿素。维生素K3（亚甲基蓝，Hykinone）和维生素K4（亚甲基红）都不是这些抗凝剂的解毒剂。/香豆素和茚满二酮/

Vitamin K1. ... For suicidal ingestions with large amounts taken, if there is uncertainty about the amount of bait ingested or the general health of the patient, phytonadione (vitamin K1) given orally protects against the anticoagulant effect of these rodenticides, with essentially no risk to the patient. In accidental ingestions with healthy children involving only a taste or single swallow, no medical treatment is required, but children should be observed for bleeding and bruising. If a larger amount may have been ingested, prothrombin time (PT) should be monitored at 24 and 48 hours, with phytonadione therapy initiated for elevated PT or clinical signs of bleeding. CAUTION: Phytonadione, specificaly, is required. Neither vitamin K3 (menadione, Hykinone) nor vitamin K4 (menadiol) is an antidote for these anticoagulants. /Coumarins and Indandiones/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

老鼠（Rattus norvegicus）口服给予杀鼠剂溴敌隆（剂量为0.8和3毫克/千克），在给药后97小时内分批处死，每批4只老鼠。检测了血浆、肝脏和肾脏中的溴敌隆含量。...该化合物从生物体中缓慢消失，0.8毫克/千克剂量的半衰期为25.7小时，3毫克/千克剂量的半衰期为57.5小时。肝脏中的浓度迅速建立，并且比血浆浓度高出14到46倍。/在0.8毫克/千克剂量给药后97小时，肝脏浓度约为1.5微克/克。肾脏中的溴敌隆水平略高于血浆中观察到的水平，且半衰期更长。

Rats (Rattus norvegicus) dosed orally with the rodenticide bromadiolone (0.8 and 3 mg/kg) were sacrificed in groups of 4 rats at various times up to 97 hr after administration. Bromadiolone was assayed in plasma, liver and kidney. ... The compound disappeared slowly from the organism with a half-life of 25.7 hr for the 0.8 mg/kg dose and 57.5 hr for the 3 mg/kg. Concentrations in liver were rapidly established and were 14- to 46-fold higher than plasma concentrations. /Liver concentrations were about 1.5 ug/g/ 97 hr after 8 mg/kg dose. Bromadiolone levels in kidney were slightly higher than those observed in plasma with a longer half-life.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

Sprague-Dawley雄性大鼠分组后通过灌胃接受单一剂量的溴敌隆、溴鼠灵或氟鼠灵（剂量为0.2毫克/千克体重）。研究中还包括了一个由9只未接受任何处理的雄性大鼠组成的对照组。......在给药后的前28天内，溴鼠灵和氟鼠灵在肝脏中的浓度下降速度比溴敌隆快，这可以通过这三种化学物质在最初28天内的半衰期（t1/2）来指示（溴敌隆：t1/2，63天；溴鼠灵：t1/2，17天；氟鼠灵：t1/2，6天）。这三种测试化学物质在肝脏中的浓度下降呈现出“双指数方式”。估计这三种化学物质的第二个半衰期分别为282天、318天和159天，对应溴敌隆、溴鼠灵和氟鼠灵。总的来说，任何这三种化学物质的口服给药都将在肝脏中长时间保留化学物质。

Groups of male Sprague-Dawley rats received a single dose (0.2 mg/kg bw) of brodifacoum, bromadiolone, or flocoumafen by gavage. A control group consisting of 9 male rats which received nothing was also included in the study. .... During the first 28 days after dosing, the decline of the liver concns of bromadiolone and flocoumafen was faster than that of brodifacoum as indicated by the t1/2's of these 3 chemicals at the first 28 days (brodifacoum: t1/2, 63 days; bromadiolone: t1/2, 17 days; flocoumafen: t1/2, 6 days). The decline of the liver concns of these 3 test chemicals occurred in a "bi-exponential manner". The second t1/2's were estimated to be 282, 318, and 159 days for brodifacoum, bromadiolone, and flocoumafen, respectively. In general, oral admin of any of these 3 chemicals would result in substantial retention of the chemical in the liver for a very long time.

来源:Hazardous Substances Data Bank (HSDB)

制备方法与用途

制备方法

1. 乙酰对溴联苯的制备：将定量的溴联苯、催化剂和溶剂混合后，在一定温度下滴加乙酸酐，加热回流数小时，蒸除溶剂。剩余物移入盛有酸液的水解瓶中分解，过滤，洗涤至中性，滤饼真空干燥，得粗品。再经处理得含量＞98%的乙酰对溴联苯。

2. 苯乙烯基对(4’-溴苯基)苯甲酮的制备：将一定量的第一步产物加入到反应瓶中，加溶剂、苯甲醛、缩合剂，在一定温度下反应。反应完毕后静置、冷却、过滤、干燥、粉碎，得粗品。含量94%。

3. 3-{2-[对(对溴苯基)苯甲酰甲基]苄基}-4-羟基香豆素的制备：依次加入上步产物、4-羟基香豆素（见杀鼠灵的制备）、溶剂、催化剂于反应瓶中，搅拌升温一定时间。然后加入溶剂，冷却结晶、过滤、干燥、粉碎，得粗品。含量94.5%。

4. 溴敌隆的合成：将上步反应产物、还原剂及两种溶剂投入反应瓶中，搅拌、升温，加入异丙醇，再搅拌一定时间。反应物料移入盛有酸液的水解瓶中进行水解，过滤、洗涤、干燥得粗产品，再经酸化处理得溴敌隆，含量95%。

合成制备方法

1. 分四步进行。

   • 第一步中间体：乙酰对溴联苯（简称第一步中间体）的制备。
   • 第二步中间体：苯乙烯基-对-(4'-溴苯基)苯甲酮（简称第二步中间体）的制备。
   • 第三步中间体：3-{2-[对-(对溴苯基)苯甲酰甲基]苄基}-4-羟基香豆素（简称第三步中间体）的制备。
   • 溴敌隆的制备。

2. 原料消耗定额：

   • 对溴联苯1100kg/t
   • 乙酐650kg/t
   • 苯甲醛500kg/t
   • 4-羟基香豆素700kg/t

3. 详细制备过程：将定量的溴联苯、催化剂和溶剂混合后，在一定温度下滴加乙酸酐，加热回流数小时，蒸除溶剂。剩余物移入盛有酸液的水解瓶中分解，过滤，洗涤至中性，滤饼真空干燥，得粗品。再经处理得到含量＞98%的乙酰对溴联苯。

   由该产物与苯甲醛等缩合得到的产物再与4-羟基香豆素反应制得3-{2-[对-(对溴苯基)苯甲酰甲基]苄基}-4-羟基香豆素。最后将该化合物、还原剂及溶剂投入反应瓶中，搅拌、升温，加入异丙醇反应，经水解、过滤、洗涤、干燥得粗产品，再经酸化处理得溴敌隆。

反应信息

• 作为反应物：
  描述：

  溴敌隆 、 trimethylsilyl 2,2,2-trifluoro-N-(trimethylsilyl)acetimidate 、 乙腈 生成 3-[3-[4-(4-bromophenyl)phenyl]-1-phenyl-3-trimethylsilyloxypropyl]-4-trimethylsilyloxychromen-2-one
  参考文献：
  名称：

  MORIN, M. F.;MERLET, N.;DORE, M.;LECHEVIN, J. C., ANALUSIS., 17,(1989) N, C. 526-531

  摘要：

  DOI：
• 作为试剂：
  描述：

  丙烯酸甲酯（MA） 、 丙二酸二乙酯 在 溴敌隆 、 五羰基铁 作用下， 反应 2.0h， 以7%的产率得到丙烷-1,1,3-三羧酸三乙酯
  参考文献：
  名称：

  Addition of malonic ester to acrylic compounds initiated by coordination initiators based on iron pentacarbonyl

  摘要：

  DOI：

  10.1007/bf00949954

文献信息

• [EN] MICROBIOCIDAL OXADIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'OXADIAZOLE MICROBIOCIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017157962A1

  公开（公告）日：2017-09-21

  Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially fungicides.

  式(I)的化合物，其中取代基如权利要求1所定义，作为杀虫剂特别是杀菌剂有用。
• [EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013079350A1

  公开（公告）日：2013-06-06

  Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.

  式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
• [EN] NEW BIARYL AMIDE DERIVATIVES<br/>[FR] NOUVEAUX DÉRIVÉS DE BIARYLAMIDE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012089601A1

  公开（公告）日：2012-07-05

  The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and A are as described herein, compositions including the compounds and methods of using the compounds.

  这项发明提供了具有通式（I）的新化合物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12和A如本文所述，包括这些化合物的组合物以及使用这些化合物的方法。
• Novel insecticides
  申请人：Syngenta Participations AG

  公开号：EP2540718A1

  公开（公告）日：2013-01-02

  Compounds of formula I wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can be used as insecticides and can be prepared in a manner known per se.

  式I的化合物 其中取代基如权利要求1所定义，并且式I化合物的农药可接受盐以及所有立体异构体和互变异构形式可用作杀虫剂，并且可以按照已知的方法制备。
• Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
  申请人：Dow AgroSciences LLC

  公开号：US20180279612A1

  公开（公告）日：2018-10-04

  This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

  这份披露涉及具有对节肢动物门、软体动物门和线虫门害虫具有杀虫效用的分子领域，用于生产此类分子的过程，用于此类过程的中间体，含有此类分子的杀虫组合物，以及使用此类杀虫组合物对抗此类害虫的过程。这些杀虫组合物可以用作螨虫剂、杀虫剂、螨虫剂、软体动物杀虫剂和线虫杀虫剂。本文件披露了具有以下式（“式一”）的分子。