5-chloroacetyl-2-morpholino-4-phenylthiazole | 209049-88-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-chloroacetyl-2-morpholino-4-phenylthiazole
• CAS: 209049-88-7
• 化学式: C₁₅H₁₅ClN₂O₂S
• 分子量: 322.815
• InChiKey: LVGISVAVLNEOQX-UHFFFAOYSA-N

物化性质

• 沸点：
  520.9±60.0 °C(predicted)
• 密度：
  1.324±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.07
• 重原子数：
  21.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  42.43
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  5-chloroacetyl-2-morpholino-4-phenylthiazole 在 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 5-[5-formyl-2-(4-morpholino)-4-thiazolyl]-2-(4-morpholino)-4-phenylthiazole
  参考文献：
  名称：

  SYNTHESIS AND SOLVATOCHROMIC PROPERTIES OF 5-DICYANOVINYL-AND 5-TRICYANOVINYL-SUBSTITUTED 2-AMINO-THIAZOLES AND 2-AMINO-THIOPHENES

  摘要：

  Starring from 2-morpholinothiazoles 6 and 2-morpholinothiophenes 7 and following known routes several 5-dicyanovinyl and 5-tricyanovinyl-substituted derivatives 10 - 13 have been prepared and their solvatochromic properties estimated.

  DOI：

  10.1080/10426509908031622
• 作为产物：
  描述：

  N-morpholine-N’-benzoylthiourea 、 1,3-二氯丙酮 在 三乙胺 作用下， 生成 5-chloroacetyl-2-morpholino-4-phenylthiazole
  参考文献：
  名称：

  Preparation and properties of 2-Dialkylamino-5-haloacetyl-thiazoles and 4-(2-Dialkylamino-5-thiazolyl)-thiazoles

  摘要：

  By the reaction of N-acylthioureas 7 with 1,3-dichloroacetone 9 2-dialkylamino-5-chloroacetyl-thiazoles 11 are avialable. These compounds react with thioureas or aryl thioamides under heterocyclisation to give bis-(2-dialkylamino-5-thiazolyl)-ketones 13, 2-aryl-4-(2-dialkylamino-5-thiazolyl)thiazoles 14, or 2-dialkylamino-4-(2-dialkylamino-5-thiazolyl)-thiazoles 15, resp., from which the last-mentioned compound exhibit a high reactivity towards several electrophilic reagents. Thus, deeply colored cyanovinyl, arylazo, and arylmethine substituted bisthiazole dyes 17, 18, and 19, resp., have been formed.

  DOI：

  10.1002/prac.19983400413