ethyl 2-((E)-4-methoxybenzylidene)butyrate | 162213-19-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: ethyl 2-((E)-4-methoxybenzylidene)butyrate
• 英文别名: ethyl (2E)-2-[(4-methoxyphenyl)methylidene]butanoate
• CAS: 162213-19-6
• 化学式: C₁₄H₁₈O₃
• 分子量: 234.295
• InChiKey: FDWYHUUQGAURAS-ZRDIBKRKSA-N

物化性质

• 沸点：
  348.2±17.0 °C(predicted)
• 密度：
  1.047±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 2-((E)-4-methoxybenzylidene)butyrate 生成 (E)-2-(4-methoxybenzylidene)butan-1-ol
  参考文献：
  名称：

  Nitro aliphatic compounds, process for preparation thereof and use

  摘要：

  新的硝基脂肪化合物及其药用可接受的盐已被披露。

  公开号：

  US04767768A1
• 作为产物：
  描述：

  2-羟基正丁酸乙酯 在 吡啶 、 aluminum oxide 、 potassium fluoride 作用下， 以 四氯化碳 、 甲苯 、 乙腈 为溶剂， 反应 97.0h， 生成 ethyl 2-((E)-4-methoxybenzylidene)butyrate
  参考文献：
  名称：

  1-Alkoxycarbonylalkylidenetriphenylarsoranes: Preparation and reactions

  摘要：

  The higher homologues of the well-studied alkoxycarbonylmethylenetriphenylarsonium(1) ylide (3, R=H) can be easily obtained through the sequence: a). preparation of alkyl 2-trifloxyalkanoates (1); b), reaction between these trifloxyderivatives and triphenylphosphine to give 1-alkoxycarbonylalkyltriphenylarsonium triflates (2); and c), basic treatment of the triphenylarsonium triflates (2) with alumina-supported potassium fluoride to give 1-alkoxycarbonylalkyledenetriphenylarsonium ylides (3). These higher homologues of(3, R=H) react with aromatic aldehydes in good to excellent yields. and give rise to synthetically interesting ''coupling'' and cyclopropanation reactions.

  DOI：

  10.1016/s0040-4020(01)85688-x

文献信息

• Substituted phenylpropionic acid derivatives
  申请人：——

  公开号：US20030187068A1

  公开（公告）日：2003-10-02

  The invention provides novel substituted phenylpropionic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor a (PPAR&agr;) to activate and exhibit potent lipid-decreasing action, and processes for preparing them. It relates to substituted phenylpropionic acid derivatives represented by a general formula (1) 1 [wherein R 1 denotes a lower alkyl group with carbon atoms of 1 to 4, lower alkoxy group with carbon atoms of 1 to 3, trifluoromethyl group, trifluoromethoxy group, phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents, R 2 denotes a hydrogen atom, lower alkyl group with carbon atoms of 1 to 4 or lower alkoxy group with carbon atoms of 1 to 3, R 3 denotes a lower alkoxy group with carbon atoms of 1 to 3, and the binding mode of A portion denotes —CH 2 CONH—, —NHCOCH 2 —, —CH 2 CH 2 CO—, —CH 2 CH 2 CH 2 —, —CH 2 CH 2 O—, —CONHCH 2 —, —CH2NHCH 2 —, —COCH 2 O—, —OCH 2 CO—, —COCH 2 NH— or —CHCH 2 CO—], their pharmaceutically acceptable salts and their hydrates, and processes for preparing them.

  该发明提供了新型取代苯丙酸衍生物，它们作为人类过氧化物酶体增殖物激活受体α（PPARα）的配体结合，激活并表现出强效的降脂作用，并提供了制备它们的方法。它涉及由通式（1）1表示的取代苯丙酸衍生物，其中R1表示具有1至4个碳原子的较低烷基基团，具有1至3个碳原子的较低烷氧基团，三氟甲基基团，三氟甲氧基团，苯基（未取代或可能具有取代基团），苯氧基（未取代或可能具有取代基团）或苄氧基（未取代或可能具有取代基团），R2表示氢原子，具有1至4个碳原子的较低烷基基团或具有1至3个碳原子的较低烷氧基团，R3表示具有1至3个碳原子的较低烷氧基团，A部分的结合模式表示为—CH2CONH—，—NHCOCH2—，—CH2CH2CO—，—CH2CH2CH2—，—CH2CH2O—，—CONHCH2—，—CH2NHCH2—，—COCH2O—，—OCH2CO—，—COCH2NH—或—CHCH2CO—，它们的药学上可接受的盐和水合物，以及制备它们的方法。
• Nitro aliphatic compounds and use thereof
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04782088A1

  公开（公告）日：1988-11-01

  The invention relates to compounds of antihypertensive and antithrombotic activity of the formula or its pharmaceutically acceptable salt: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, or lower alkoxyphenyl, R.sup.2 is hydrogen or lower alkyl, R.sup.4 is lower alkyl, R.sup.6 is hydrogen or lower alkyl, R.sup.7 is lower alkyl which is optionally substituted by hydroxy or lower alkanoyloxy, and R.sup.10 is hydrogen or lower alkyl which is optionally substituted by carboxy or esterified carboxy.

  本发明涉及具有抗高血压和抗血栓活性的化合物的公式或其药学上可接受的盐：##STR1## 其中R.sup.1是氢，低碳基或低碳氧基苯基，R.sup.2是氢或低碳基，R.sup.4是低碳基，R.sup.6是氢或低碳基，R.sup.7是低碳基，可选地被羟基或低碳酰氧基取代，而R.sup.10是氢或低碳基，可选地被羧基或酯化羧基取代。
• SUBSTITUTED PHENYLPROPIONIC ACID DERIVATIVES
  申请人：KYORIN PHARMACEUTICAL CO., LTD.

  公开号：EP1285908A1

  公开（公告）日：2003-02-26

  The invention provides novel substituted phenylpropionic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor α (PPARα) to activate and exhibit potent lipid-decreasing action, and processes for preparing them.    It relates to substituted phenylpropionic acid derivatives represented by a general formula (1) [wherein R1 denotes a lower alkyl group with carbon atoms of 1 to 4, lower alkoxy group with carbon atoms of 1 to 3, trifluoromethyl group, trifluoromethoxy group, phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents, R2 denotes a hydrogen atom, lower alkyl group with carbon atoms of 1 to 4 or lower alkoxy group with carbon atoms of 1 to 3, R3 denotes a lower alkoxy group with carbon atoms of 1 to 3, and the binding mode of A portion denotes -CH2CONH-, -NHCOCH2-, -CH2CH2CO-, -CH2CH2CH2-, -CH2CH2O-, -CONHCH2-, -CH2NHCH2-, -COCH2O-, -OCH2CO-, -COCH2NH- or -NHCH2CO-], their pharmaceutically acceptable salts and their hydrates, and processes for preparing them.

  本发明提供了新型取代的苯基丙酸衍生物，这些衍生物作为人类过氧化物酶体增殖激活受体α（PPARα）的配体与受体结合，从而激活并表现出强效的降脂作用，本发明还提供了制备这些衍生物的工艺。 它涉及通式（1）所代表的取代苯丙酸衍生物 [其中 R1 表示碳原子数为 1 至 4 的低级烷基、碳原子数为 1 至 3 的低级烷氧基、三氟甲基、三氟甲氧基、未取代或可能有取代基的苯基、未取代或可能有取代基的苯氧基或未取代或可能有取代基的苄氧基，R2 表示氢原子、R2表示氢原子、碳原子数为 1 至 4 的低级烷基或碳原子数为 1 至 3 的低级烷氧基，R3 表示碳原子数为 1 至 3 的低级烷氧基，A 部分的结合方式表示-CH2CONH-、-NHCOCH2-、-CH2CH2CO-、-CH2CH2CH2-、-CH2CH2O-、-CONHCH2-、-CH2NHCH2-、-COCH2O-、-OCH2CO-、-COCH2NH-或-NHCH2CO-]，它们的药学上可接受的盐和它们的水合物，以及制备它们的工艺。
• New nitro aliphatic compounds, process for preparation thereof and use thereof
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0113106B1

  公开（公告）日：1986-05-14
• OKAMOTO, MASANORI;IWAMI, MORITA;TAKASE, SHIGEHIRO;UCHIDA, ITSUO;UMEHARA, +
  作者：OKAMOTO, MASANORI、IWAMI, MORITA、TAKASE, SHIGEHIRO、UCHIDA, ITSUO、UMEHARA, +

  DOI：——

  日期：——