(E)-8-chloro-N-(4-isopropylstyryl)-4-methoxyquinoline-2-carboxamide | 1421606-80-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (E)-8-chloro-N-(4-isopropylstyryl)-4-methoxyquinoline-2-carboxamide
• 英文别名: 8-chloro-4-methoxy-N-[(E)-2-(4-propan-2-ylphenyl)ethenyl]quinoline-2-carboxamide
• CAS: 1421606-80-5
• 化学式: C₂₂H₂₁ClN₂O₂
• 分子量: 380.874
• InChiKey: BSNSVLSHPUGQII-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-异丙基肉硅酸 在 N-溴代丁二酰亚胺(NBS) 、 噻吩-2-甲酸亚铜(I) 、 caesium carbonate 、 三乙胺 、 N,N'-二甲基乙二胺 作用下， 以 二氯甲烷 为溶剂， 生成 (E)-8-chloro-N-(4-isopropylstyryl)-4-methoxyquinoline-2-carboxamide
  参考文献：
  名称：

  Synthesis of Perspicamide A and Related Diverse Analogues: Their Bioevaluation as Potent Antileishmanial Agents

  摘要：

  The first protocol for the synthesis of perspicamide A and related diverse analogues has been developed from economical and readily available starting materials. Furthermore, a few synthesized analogues, 24a, 246, 24c, 24d, and 241, exhibited potent activity against Leishmania donovani with IC50 values ranging from 3.75 to 10.37 mu M and a selectivity index (SI) ranging from 9.58 to 53.12, which is improved compared to the standard drug Miltefosine (IC50 12.4 mu M and SI 4.1).

  DOI：

  10.1021/jo3025626

文献信息

• Synthesis of Perspicamide A and Related Diverse Analogues: Their Bioevaluation as Potent Antileishmanial Agents
  作者：Anand Kumar Pandey、Rashmi Sharma、Rahul Shivahare、Ashish Arora、Neeraj Rastogi、Suman Gupta、Prem M. S. Chauhan

  DOI：10.1021/jo3025626

  日期：2013.2.15

  The first protocol for the synthesis of perspicamide A and related diverse analogues has been developed from economical and readily available starting materials. Furthermore, a few synthesized analogues, 24a, 246, 24c, 24d, and 241, exhibited potent activity against Leishmania donovani with IC50 values ranging from 3.75 to 10.37 mu M and a selectivity index (SI) ranging from 9.58 to 53.12, which is improved compared to the standard drug Miltefosine (IC50 12.4 mu M and SI 4.1).