presence of mercuric cyanide gave, in 86% yield after O -deacetylation followed by column chromatography, benzyl 2,3,6-tri- O -benzyl-β-cellobioside, which was catalytically hydrogenolyzed to afford cellobiose. In a similar way, methyl α-cellobioside, cellotriose, methyl α- and β-cellotriosides, cellotetraose, lactose, and methyl α-lactoside were synthesized with high stereospecificity and in good yield
摘要1,3,4,6-四-O-乙酰基-α-d-
吡喃
葡萄糖基
溴化物(1)与1,2,3,6-三-O-苄基-β-d-
吡喃
葡萄糖苷(6)的缩合反应在
氰化汞存在下,用1:1的苯-
硝基甲烷进行O-脱乙酰化,然后进行柱色谱纯化,产率为86%,将苄基2,3,6-三-O-苄基-β-
纤维二糖苷催化
水解生成
纤维二糖。以类似的方式,使用甲基2,3,6,通过偶联反应以高立体特异性和高收率合成了甲基α-
纤维二糖苷,
纤维三糖,甲基α-和β-纤维糖苷,
纤维四糖,
乳糖和甲基α-
乳糖苷。 -三-O-苄基-α-和-β-d-
吡喃
葡萄糖苷6和苄基2,3,6,2',3',6'-六-O-苄基-β-
纤维二糖苷作为糖基受体,和1,2,3,4,6-四-O-乙酰基-α-d-
吡喃半
乳糖基
溴化物,