[(2S,3S,4S,6R)-4-[tert-butyl(dimethyl)silyl]oxy-2-methyl-6-[[(1S,2R,6R,8R,9S)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methoxy]oxan-3-yl] acetate | 916993-22-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(2S,3S,4S,6R)-4-[tert-butyl(dimethyl)silyl]oxy-2-methyl-6-[[(1S,2R,6R,8R,9S)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methoxy]oxan-3-yl] acetate
• CAS: 916993-22-1
• 化学式: C₂₆H₄₆O₁₀Si
• 分子量: 546.731
• InChiKey: ZOZKDPZEFVENDW-MCLHYDDOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.86
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  100
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  4-O-Acetyl-1,5-anhydro-2,6-dideoxy-3-O-(tert-butyldimethylsilyl)-L-arabino-hex-1-enitol 、 双丙酮半乳糖 在 三苯基膦氢溴酸盐 作用下， 以 二氯甲烷 为溶剂， 以78%的产率得到[(2S,3S,4S,6R)-4-[tert-butyl(dimethyl)silyl]oxy-2-methyl-6-[[(1S,2R,6R,8R,9S)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-8-yl]methoxy]oxan-3-yl] acetate
  参考文献：
  名称：

  Recent advances in the synthesis of 2-deoxy-glycosides

  摘要：

  Glycosides of 2-deoxy-sugars, monosaccharides in which the hydroxyl group at C-2 is replaced with a hydrogen atom, occur widely in natural products and therefore have been the subject of intense synthetic activity. The report summarizes recent advances in this area, with a particular focus on work published since an earlier review on the topic, in 2000 (Marzabadi, C. H.: Franck, R. W. Tetrahedron 2000, 56, 8385-8417). (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2009.07.013