5-[4-[2-[(pyridin-2-yl)oxy]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 5-[4-[2-[(pyridin-2-yl)oxy]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione
• 英文别名: 5-[4-[2-[(pyridin-2-yl)oxy]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepin-2,4(3H,5H)-dione；5-[4-[2-[(Pyridin-2-yl)oxy]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione；N-[4-(2,4-dioxo-1H-benzo[g][1,5]benzodiazepin-5-yl)phenyl]-2-pyridin-2-yloxyacetamide
• 化学式: C₂₆H₂₀N₄O₄
• 分子量: 452.469
• InChiKey: RQVODWRHAFGVHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  特定基氨基甲酸脂酶 在 platinum(IV) oxide 、 四(三苯基膦)钯 、 氢气 、 sodium hydride 、 碳酸氢钠 、 potassium carbonate 、 三乙胺 、 三苯基膦 、 三氟乙酸 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 氯仿 、 N,N-二甲基甲酰胺 、 甲苯 、 mineral oil 为溶剂， 反应 31.5h， 生成 5-[4-[2-[(pyridin-2-yl)oxy]acetylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione
  参考文献：
  名称：

  P2X4 RECEPTOR ANTAGONIST

  摘要：

  公开号：

  EP2803662B1

文献信息

• P2X4 receptor antagonist
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：US09382236B2

  公开（公告）日：2016-07-05

  The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R1 and R2 represent hydrogen atom and the like, or R1 and R2 bind together to form a naphthalene ring and the like together with the benzene ring to which they bind, R3 and R4 represent hydrogen atom and the like, R5 represents hydrogen atom and the like, R6 and R7 represent hydrogen atom and the like, X represents C, CH or N, Y represents N, NH or C(═O), provided that when X is N, Y is not N or NH, and when X is C or CH, Y is not C(═O), Z represents oxygen atom or sulfur atom, A represents benzene ring and the like, B represents NHC(═O) and the like, D represents an atomic bond and the like, E represents an atomic bond and the like, G represents benzene which may be substituted and the like, and m represents an integer of 0 to 5) or a pharmacologically acceptable salt thereof, and a P2X4 receptor antagonist.

  本发明涉及一种二氮杂吡啶衍生物，其由下述通式（I）表示（在该式中，R1和R2表示氢原子等，或者R1和R2结合在一起形成萘环等，与它们结合的苯环一起，R3和R4表示氢原子等，R5表示氢原子等，R6和R7表示氢原子等，X表示C、CH或N，Y表示N、NH或C（=O），前提是当X为N时，Y不是N或NH，当X为C或CH时，Y不是C（=O），Z表示氧原子或硫原子，A表示苯环等，B表示NHC（=O）等，D表示原子键等，E表示原子键等，G表示苯环，可以被取代等，m表示0至5的整数），或其药学上可接受的盐，以及P2X4受体拮抗剂。
• MEDICINE FOR DIABETIC PERIPHERAL NEUROPATHY
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：EP3848051A1

  公开（公告）日：2021-07-14

  The present invention relates to a medicine for preventing or treating pain in nociceptive pain, inflammatory pain, or neuropathic pain, the medicine comprising, as an active ingredient, a compound having a P2X4 receptor antagonist action, a tautomer of the compound, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof. The medicine has no effect on driving or machine operation ability, has no effect on car driving ability, does not require any restriction to administration thereof to a patient engaging in operation of a dangerous machine including driving a car, or can be administered to a patient engaging in operation of a dangerous machine including driving a car.

  本发明涉及一种用于预防或治疗痛觉疼痛、炎症性疼痛或神经病理性疼痛的药物，该药物作为活性成分包括具有P2X4受体拮抗剂作用的化合物、该化合物的同系物、其立体异构体、其药学上可接受的盐、其水合物或其溶液。该药物对驾驶或机器操作能力无影响，对汽车驾驶能力无影响，对从事危险机器操作（包括驾驶汽车）的患者用药无任何限制，或可对从事危险机器操作（包括驾驶汽车）的患者用药。
• MEDICAMENT FOR TREATMENT OF MULTIPLE SCLEROSIS
  申请人：NIPPON CHEMIPHAR CO., LTD.

  公开号：US20210121478A1

  公开（公告）日：2021-04-29

  A medicament for preventive and/or therapeutic treatment of multiple sclerosis, especially a pain accompanying multiple sclerosis such as neuropathic pain, which contains a compound having a P2X4 receptor antagonist activity such as a compound represented by the general formula (IH), or a salt thereof, or a hydrate or solvate thereof as an active ingredient.
• US9382236B2
  申请人：——

  公开号：US9382236B2

  公开（公告）日：2016-07-05
• US9969700B2
  申请人：——

  公开号：US9969700B2

  公开（公告）日：2018-05-15