(2R,3R,4R,5S,6S)-2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)-6-methyltetrahydro-2H-pyran-3,4,5-triyl triacetate | 1173186-39-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4R,5S,6S)-2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)-6-methyltetrahydro-2H-pyran-3,4,5-triyl triacetate
• CAS: 1173186-39-4
• 化学式: C₁₈H₂₉BrO₁₀
• 分子量: 485.326
• InChiKey: PWAARWAQLJKXPN-RNEPWOLLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.97
• 重原子数：
  29.0
• 可旋转键数：
  12.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  115.82
• 氢给体数：
  0.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  (2R,3R,4R,5S,6S)-2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)-6-methyltetrahydro-2H-pyran-3,4,5-triyl triacetate 、 三(三甲代甲硅烷基)亚磷酸盐 反应 5.0h， 以100%的产率得到[(2S,3S,4R,5R,6R)-4,5-diacetyloxy-2-methyl-6-[2-[2-[2-[oxido-bis(trimethylsilyloxy)phosphaniumyl]ethoxy]ethoxy]ethoxy]oxan-3-yl] acetate
  参考文献：
  名称：

  Water-Soluble Rhamnose-Coated Fe₃O₄ Nanoparticles

  摘要：

  Water-soluble biocompatible rhamnose-coated Fe3O4 nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.

  DOI：

  10.1021/ol900949y
• 作为产物：
  描述：

  在 四溴化碳 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 以89%的产率得到(2R,3R,4R,5S,6S)-2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)-6-methyltetrahydro-2H-pyran-3,4,5-triyl triacetate
  参考文献：
  名称：

  Water-Soluble Rhamnose-Coated Fe₃O₄ Nanoparticles

  摘要：

  Water-soluble biocompatible rhamnose-coated Fe3O4 nanoparticles of 4.0 nm are obtained by covalent anchorage of rhamnose on the nanoparticles surface via a phosphate linker. These nanoparticles present superparamagnetic behavior and nuclear relaxivities in the same order of magnitude as Endorem that make them potential magnetic resonance imaging (MRI) contrast agents of a second generation, where the saccharides represent also specific ligands able to target lectins on skin cells.

  DOI：

  10.1021/ol900949y