1,6-二氯萘 | 2050-72-8

• 物质功能分类: 有机原料 - 烃类化合物及其衍生物 - 芳香烃
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1,6-二氯萘
• 英文名称: 1,6-dichloronaphthalene
• 英文别名: 1,6-Dichlor-naphthalin
• CAS: 2050-72-8
• 化学式: C₁₀H₆Cl₂
• 分子量: 197.064
• InChiKey: CEDZMDSZTVUPSP-UHFFFAOYSA-N

物化性质

• 熔点：
  49 °C
• 沸点：
  296.8±13.0 °C(Predicted)
• 密度：
  1.336±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（少许）、DMSO（少许）
• 保留指数：
  1639.6

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903999090

反应信息

• 作为反应物：
  描述：

  1,6-二氯萘 在 硝酸 作用下， 生成 4-氯邻苯二酸
  参考文献：
  名称：

  Cleve, 1878, # 5, p. 3

  摘要：

  DOI：
• 作为产物：
  描述：

  6-氯萘-1-磺酰氯 生成 1,6-二氯萘
  参考文献：
  名称：

  Armstrong; Wynne, Chemical news and journal of industrial science, 1895, vol. 71, p. 253

  摘要：

  DOI：

文献信息

• Novel Sulfonaminoquinoline Hepcidin Antagonists
  申请人：Buhr Wilm

  公开号：US20120214803A1

  公开（公告）日：2012-08-23

  The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.

  本发明涉及新型肝铁蛋白拮抗剂，包括它们的药物组合物以及将其用作药物治疗铁代谢紊乱，特别是铁缺乏病和贫血等疾病，特别是与慢性炎症性疾病相关的贫血。
• Identification of the Temporal Components of Seizure Onset in the Scalp EEG
  作者：Nora S. O'Neill、Zoltan J. Koles、Manouchehr Javidan

  DOI：10.1017/s0317167100001402

  日期：2001.8

  The identification of the earliest indication of rhythmical oscillations and paroxysmal events associated with an epileptic seizure is paramount in identifying the location of the seizure onset in the scalp EEG. In this work, data-dependent filters are designed that can help reveal obscure activity at the onset of seizures in problematic EEGs.

  Data-dependent filters were designed using temporal patterns common to selected segments from pre-ictal and ictal portions of the scalp EEG. Temporal patterns that accounted for more variance in the ictal segment than in the pre-ictal segment of the scalp EEG were used to form the filters.

  Application of the filters to the scalp EEG revealed temporal components in the seizure onset in the scalp recording that were not obvious in the unfiltered EEG. Examination of the filtered EEG enabled the onset of the seizure to be recognized earlier in the recording. The utility of the filters was confirmed qualitatively by comparing the scalp recording to the intracranial recording and quantitatively by calculating correlation coefficients between the scalp and intracranial recordings before and after filtering.

  The data-dependent approach to EEG filter design allows automatic detection of the basic frequencies present in the seizure onset. This approach is more effective than narrow band-pass filtering for eliminating artifactual and other interference that can obscure the onset of a seizure. Therefore, temporal-pattern filtering facilitates the identification of seizure onsets in challenging scalp EEGs.

  背景：识别与癫痫发作相关的节律性振荡和阵发性事件的最早迹象，对于确定头皮脑电图中癫痫发作的起始位置至关重要。方法：利用头皮脑电图发作前和发作期部分所选片段的共同时间模式设计了数据依赖性滤波器。结果：将滤波器应用于头皮脑电图，发现了头皮记录中癫痫发作开始的时间成分，而这些成分在未经滤波的脑电图中并不明显。对过滤后的脑电图进行检查，可以在记录中更早地识别出癫痫发作的起始时间。通过比较头皮记录和颅内记录，对滤波器的效用进行了定性确认；通过计算头皮记录和颅内记录在滤波前后的相关系数，对滤波器的效用进行了定量确认。与窄带通滤波器相比，这种方法能更有效地消除可能掩盖癫痫发作起始点的假性干扰和其他干扰。因此，时间模式滤波有助于在具有挑战性的头皮脑电图中识别癫痫发作的起始点。
• New reactivity patterns of copper(I) and other transition metal NHC complexes: application to ATRC and related reactions
  作者：James A. Bull、Michael G. Hutchings、Cristina Luján、Peter Quayle

  DOI：10.1016/j.tetlet.2007.12.084

  日期：2008.2

  Pre-formed transition metal–NHC complex is shown to be an effective catalyst for Atom Transfer Radical Cyclisation (ATRC) reactions.

  预先形成过渡金属- NHC络合物证明是一种有效的催化剂甲汤姆Ť转让（BOT）- [R adical Ç yclisation（ATRC）反应。
• An unusual decarboxylative benzannulation and biaryl formation during copper(I)-promoted halogen atom transfer radical cyclization of 2-allylaryl trichloroacetates
  作者：Ram N. Ram、Ram K. Tittal、Shailesh Upreti

  DOI：10.1016/j.tetlet.2007.09.058

  日期：2007.11

  CuCl/bpy-promoted halogen atom transfer radical cyclization of 2-allylaryl trichloroacetates in refluxing benzene gave benzannulated chloroarenes and benzannulated symmetrical biaryls along with reductive dehalogenation products. The unusual decarboxylative benzannulation and biaryl formation might be explained by a further intramolecular radical addition on the benzene ring of the eight-membered lactone

  在回流的苯中，CuCl / bpy促进的三氯乙酸2-烯丙基芳基酯的卤原子转移自由基环化反应生成苯并环化的氯芳烃和苯并环化的对称联芳基以及还原性脱卤产物。这种不寻常的脱羧苯并环化和联芳形成可能是由分子内进一步基加八元内酯中间体的苯环上进行说明，最初是通过8-形成内切- TRIG卤素原子转移自由基环化，然后进行脱羧反应，自由基二聚化和脱氯化氢反应。
• NAPHTHOBISCHALCOGENADIAZOLE DERIVATIVE AND PRODUCTION METHOD THEREFOR
  申请人：OSAKA UNIVERSITY

  公开号：US20190337966A1

  公开（公告）日：2019-11-07

  In order to provide a naphthobischalcogenadiazole derivative that can be used as an intermediate for producing a naphthobischalcogenadiazole compound into which a fluorine atom has been introduced, the naphthobischalcogenadiazole derivative in accordance with an aspect of the present invention is represented by a formula (I): where each of A 1 and A 2 is independently an oxygen atom, a sulfur atom, a selenium atom, or a tellurium atom; and each of X 1 and X 2 is independently a hydrogen atom, a halogen atom, a boronic acid group, a boronic acid ester group, a boronic acid diaminonaphthalene amide group, an N-methyliminodiacetic acid boronate group, a trifluoroborate salt group, or a triolborate salt group.

  为了提供一种可用作生产引入氟原子的萘基双硫/硒/碲-二唑化合物的中间体的萘基双硫/硒/碲-二唑衍生物，本发明的一个方面提供的萘基双硫/硒/碲-二唑衍生物由式(I)表示：其中，A1和A2分别独立地为氧原子、硫原子、硒原子或碲原子；X1和X2分别独立地为氢原子、卤素原子、硼酸基、硼酸酯基、硼酸二氨基萘酰胺基、N-甲基亚乙二酸硼酸酯基、三氟硼酸盐基或三羟基硼酸盐基。