| 852311-20-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 852311-20-7
• 化学式: C₄₆H₇₈F₃N₇O₁₉
• 分子量: 1090.16
• InChiKey: SNWOBTYGFDRDOT-MGENDDLXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  75.0
• 可旋转键数：
  11.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  350.95
• 氢给体数：
  10.0
• 氢受体数：
  19.0

反应信息

• 作为反应物：
  描述：

  在 ammonium hydroxide 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  A proof of the specificity of kanamycin-ribosomal RNA interaction with designed synthetic analogs and the antibacterial activity

  摘要：

  The binding specificity of designed synthetic kanamycins with model RNA sequences (wild-type and point-mutated type) derived from the 16S ribosomal A-site was evaluated using surface plasmon resonance imaging. It was observed that kanamycins have nonspecific and multiple interactions with RNA hairpins and that the binding potency is not always proportional to the antimicrobial activity. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.043
• 作为产物：
  描述：

  2',3,6'-tri-N-t-butoxycarbonyl-3''-trifluoroacetyl-dibekacin 、 N,N′-二-Boc-硫脲 在 三乙胺 、 mercury dichloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以67%的产率得到
  参考文献：
  名称：

  A proof of the specificity of kanamycin-ribosomal RNA interaction with designed synthetic analogs and the antibacterial activity

  摘要：

  The binding specificity of designed synthetic kanamycins with model RNA sequences (wild-type and point-mutated type) derived from the 16S ribosomal A-site was evaluated using surface plasmon resonance imaging. It was observed that kanamycins have nonspecific and multiple interactions with RNA hairpins and that the binding potency is not always proportional to the antimicrobial activity. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.043