(4-丙酰基苯氧基)-乙酸 | 6501-31-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (4-丙酰基苯氧基)-乙酸
• 英文名称: (4-Propionyl-phenoxy)-essigsaeure
• 英文别名: (4-Propionyl-phenoxy)-acetic acid；2-(4-propanoylphenoxy)acetic acid
• CAS: 6501-31-1
• 化学式: C₁₁H₁₂O₄
• mdl: MFCD00455856
• 分子量: 208.214
• InChiKey: FBTYYZZUMRUNGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  (4-丙酰基苯氧基)-乙酸 在 吗啉 、 sulfur 作用下， 生成 3-<4-Methoxycarbonyl-phenyl>-propionsaeure-methylester
  参考文献：
  名称：

  Tyler; Whittaker, Journal of Applied Chemistry, 1959, vol. 9, p. 594,595-599

  摘要：

  DOI：
• 作为产物：
  描述：

  碘乙酸 、 4-羟基苯丙酮 在 sodium hydroxide 、 盐酸 作用下， 生成 (4-丙酰基苯氧基)-乙酸
  参考文献：
  名称：

  Ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit—Potential anti-metastatic drugs

  摘要：

  A series of ethacrynic acid analogues, lacking the alpha,beta-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, MCF-7/AZ. Several of the analogues were already active in the low micromolar range, whereas ethacrynic acid itself shows no potential to inhibit the migration of these cancer cells. Preliminary studies show that the presence of one or more methoxy groups at the phenyl ring of ethacrynic acid is important in order for the ethacrynic acid analogues to demonstrate an inhibitory effect on the migration. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.01.144

文献信息

• ACTIVATOR OF ADIPONECTIN RECEPTOR
  申请人：THE UNIVERSITY OF TOKYO

  公开号：US20160214967A1

  公开（公告）日：2016-07-28

  An AdipoR activator for activating both AdipoR1 and AdipoR2 is provided. A compound represented by the following formula (1), wherein A is a substituted or unsubstituted aryl group or the like, Y 1 is (CHR 2 ) a — or the like, X is CH or N, R 1 is a C 1-7 alkyl group, m is an integer of 0-4, Y 2 is *—O—CH 2 —CONH—, *—CONH—(CH 2 ) b —CO— or the like, Z is a cyclic group, B may be a substituent of the cyclic group represented by Z, and n is an integer of 0-3.

  提供了一种用于激活AdipoR1和AdipoR2的AdipoR激活剂。以下式（1）表示的化合物，其中A是取代或未取代的芳基或类似物，Y1是（CHR2）a—或类似物，X是CH或N，R1是C1-7烷基基团，m是0-4的整数，Y2是*—O—CH2—CONH—，*—CONH—（CH2）b—CO—或类似物，Z是环基团，B可以是Z代表的环基团的取代基，n是0-3的整数。
• ADIPONECTIN RECEPTOR-ACTIVATING COMPOUND
  申请人：The University of Tokyo

  公开号：EP3053911A1

  公开（公告）日：2016-08-10

  An AdipoR activator for activating both AdipoR1 and AdipoR2 is provided. A compound represented by the following formula (1), wherein A is a substituted or unsubstituted aryl group or the like, Y1 is (CHR2)a- or the like, X is CH or N, R1 is a C1-7 alkyl group, m is an integer of 0-4, Y2 is *-O-CH2-CONH-, *-CONH-(CH2)b-CO- or the like, Z is a cyclic group, B may be a substituent of the cyclic group represented by Z, and n is an integer of 0-3.

  本发明提供了一种可同时激活 AdipoR1 和 AdipoR2 的 AdipoR 激活剂。一种由下式（1）代表的化合物，其中 A 是取代或未取代的芳基或类似物，Y1 是 (CHR2)a- 或类似物，X 是 CH 或 N，R1 是 C1-7 烷基，m 是 0-4 的整数，Y2 是 *-O-CH2-CONH-、*-CONH-(CH2)b-CO- 或类似物，Z 是环状基团，B 可以是 Z 所代表的环状基团的取代基，n 是 0-3 的整数。
• IMMOBILIZATION OF PHENOLIC COMPOUNDS
  申请人：Spago Nanomedical AB

  公开号：EP3838967A1

  公开（公告）日：2021-06-23

  The present disclosure relates to a method of immobilizing a phenolic compound having a Mw ≥ 500 g/mol, wherein the method comprises the steps of ionizing the phenolic compound by subjecting it to a base; and contacting, under agitation, the ionized phenolic compound with a cross-linked resin comprising the functionality of -C(=O)-CHXCH2R, wherein X is chosen from the group consisting of Br, Cl, I, CN, OMs, OTs, or OTf, and R is H, CH3 or an branched or unbranched alkyl having 1 to 8 carbon atoms, in the presence of a base and a solvent. The present disclosure also relates to a method of removing phenolic compounds having a Mw ≥ 500 g/mol from a composition comprising compounds having at least one alkoxysilane group. The present disclosure also relates to the use of a method according to the present disclosure as well as to a product, from which at least one phenolic compound having a Mw ≥ 500 g/mol has been removed by a method according to the present disclosure.

  本公开涉及一种固定化酚类化合物的方法，该酚类化合物的 Mw ≥ 500 g/mol；在搅拌下，将离子化的酚类化合物与交联树脂接触，交联树脂的官能度为 -C(＝O)-CHXCH2R，其中 X 选自 Br、Cl、I、CN、OMs、OTs 或 OTf 组成的组，R 为 H、CH3 或具有 1 至 8 个碳原子的支链或未支链烷基。本发明还涉及一种从包含至少有一个烷氧基硅烷基团的化合物的组合物中去除 Mw ≥ 500 g/mol 的酚类化合物的方法。本发明还涉及根据本发明公开的方法的使用以及产品，根据本发明公开的方法已从该产品中除去至少一种Mw≥500 g/mol的酚类化合物。
• KULIEV A. M.; SARDAROVA S. A.; MAMEDOV F. N.; GUSEJNOV M. S., V. SB. PRISADKI K SMAZOCH. MASLAM, VYP. 4. BAKU, EHLM, 1976, 116-120
  作者：KULIEV A. M.、 SARDAROVA S. A.、 MAMEDOV F. N.、 GUSEJNOV M. S.

  DOI：——

  日期：——
• US5973188A
  申请人：——

  公开号：US5973188A

  公开（公告）日：1999-10-26