1-Hydroxymethyl-4-methyl-cyclohexanol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Hydroxymethyl-4-methyl-cyclohexanol
• 英文别名: 1-Hydroxy-4-methyl-1-hydroxymethyl-cyclohexan；4-Methyl-1-methylol-cyclohexanol-(1)；1-(Hydroxymethyl)-4-methylcyclohexanol；1-(hydroxymethyl)-4-methylcyclohexan-1-ol
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: XAQVBIBXZCFNDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-甲基-4-亚甲基环己烷 在 potassium permanganate 作用下， 生成 1-Hydroxymethyl-4-methyl-cyclohexanol
  参考文献：
  名称：

  Wallach; Evans, Justus Liebigs Annalen der Chemie, 1906, vol. 347, p. 346

  摘要：

  DOI：

文献信息

• [EN] SHIP1 MODULATORS AND METHODS RELATED THERETO<br/>[FR] MODULATEURS DE SHIP1 ET MÉTHODES ASSOCIÉES
  申请人：AQUINOX PHARMACEUTICALS INC

  公开号：WO2014143561A1

  公开（公告）日：2014-09-18

  Compounds of formula (I): where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

  式（I）的化合物：其中R1、R2、R3、R4a、R4b、R5、R6和R7如本文所定义，或其立体异构体或药学上可接受的盐，在本文中有描述。这些化合物具有SHIP1调节剂的活性，因此可用于治疗任何需要SHIP1调节的各种疾病、疾病或病况。还公开了包含式（I）化合物与药学上可接受的载体或稀释剂组合的组合物，以及通过向需要的动物施用这些化合物来进行SHIP1调节的方法。
• [EN] SHIP1 MODULATORS AND METHODS RELATED THERETO<br/>[FR] MODULATEURS DE SHIP1 ET PROCÉDÉS ASSOCIÉS
  申请人：AQUINOX PHARMACEUTICALS INC

  公开号：WO2014158654A1

  公开（公告）日：2014-10-02

  Compounds of formula (II): wherein A, R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds have activity as SHIP1 modulators, and thus may be useful in treating a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of the invention are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

  公式（II）的化合物：其中A、R1、R2、R5和R13如本文所述，或其立体异构体、对映体、互变异构体或其混合物，或其药用可接受的盐或溶剂化物，本文也描述了其他化合物。这些化合物具有作为SHIP1调节剂的活性，因此可能用于治疗多种可以从SHIP1调节中受益的疾病、失调或状况。还披露了包含本发明化合物的组合物，以及通过向需要的动物施用此类化合物来进行SHIP1调节的方法。
• Selective transition-metal-free vicinal cis-dihydroxylation of saturated hydrocarbons
  作者：Luis Bering、Andrey P. Antonchick

  DOI：10.1039/c6sc03055f

  日期：——

  A transition-metal-free cis-dihydroxylation of saturated hydrocarbons under ambient reaction conditions has been developed. The described approach allows a direct and selective synthesis of vicinal diols. The new reaction thereby proceeds via radical iodination and a sequence of oxidation steps. A broad scope of one-pot dual C(sp3)–H bond functionalization for the selective synthesis of vicinal syn-diols

  已经开发了在环境反应条件下饱和烃的无过渡金属的顺式-二羟基化。所描述的方法允许邻位二醇的直接和选择性合成。因此，新反应通过自由基碘化和一系列氧化步骤进行。广泛范围的一锅双C（sp 3）– H键功能化的邻位合成二醇的选择性合成。
• METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE
  申请人：DAIICHI SANKYO COMPANY, LIMITED

  公开号：US20160194331A1

  公开（公告）日：2016-07-07

  The present invention is intended to provide a method for efficiently producing and providing a compound having a spirooxindole skeleton, for example, a compound having a spirooxindole skeleton and having antitumor activity that inhibits the interaction between Mdm2 protein and p53 protein, or an intermediate thereof, using an asymmetric catalyst. A compound having an optically active tricyclic dispiroindole skeleton is efficiently obtained through a catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

  本发明旨在提供一种有效生产和提供具有螺环氧吲哚骨架的化合物的方法，例如，利用不对称催化剂制备具有螺环氧吲哚骨架并具有抗肿瘤活性的化合物，该化合物抑制Mdm2蛋白与p53蛋白之间的相互作用，或其中间体。通过使用酮亚胺作为反应底物，并使用手性配体和Lewis酸进行催化不对称1,3-二极环加成反应，有效地获得具有光学活性的三环二螺吲哚骨架的化合物。
• Stereochemical preference of yeast epoxide hydrolase for the O-axial C3 epimers of 1-oxaspiro[2.5]octanes
  作者：Carel A. G. M. Weijers、Paul M. Könst、Maurice C. R. Franssen、Ernst J. R. Sudhölter

  DOI：10.1039/b709742e

  日期：——

  1-oxaspiro[2.5]octanes was investigated. O-axial C3 Epimers were hydrolyzed faster than the O-equatorial C3 epimers. The stereochemical preference was greatly dependent on the type of substitution on the cyclohexane ring. The preference of YEH for O-axial C3 epimers, found throughout this study, illustrates the effectiveness of YEH in enzymatic detoxification of spiroepoxides.

  1-氧杂螺[2.5]辛烷部分是许多具有生物活性的螺环氧化物化合物中的常见基序。立体化学在这些螺环氧化物的作用中起重要作用，因为O轴C3差向异构体主要负责生物活性。有鉴于此，研究了来自Rhodotorula glutinis的酵母环氧水解酶（YEH）对各种1-oxaspiro [2.5]辛烷的O轴和O赤道C3差向异构体的反应性。O轴C3差向异构体的水解速度快于O赤道C3差向异构体。立体化学偏好在很大程度上取决于环己烷环上的取代类型。贯穿本研究发现，YEH对O轴C3差向异构体的偏爱说明了YEH在螺环氧化物酶解毒中的有效性。