(1S,2R)-1-amino-6-nitro-2,3-dihydro-1H-inden-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (1S,2R)-1-amino-6-nitro-2,3-dihydro-1H-inden-2-ol
• 化学式: C₉H₁₀N₂O₃
• 分子量: 194.19
• InChiKey: CZIPZPAAIMGXIV-BDAKNGLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  92.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (1S,2R)-1-amino-6-nitro-2,3-dihydro-1H-inden-2-ol 在 三乙胺 、 tin(ll) chloride 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 N-[(1R,2S)-6-amino-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-4-ethylbenzenesulfonamide
  参考文献：
  名称：

  Aryl sulfonamido indane inhibitors of the Kv1.5 ion channel

  摘要：

  A collection of aryl sulfonamido indanes based on the lead compound I was synthesized and evaluated for Kv1.5 inhibitory activity. Kv1.5 inhibitors have the potential to be atrium-selective agents for treatment of atrial fibrillation. (1R,2R)-1 has an IC50 of 0.033 mu M against Kv1.5 and is selective against other cardiac ion channels, including hERG. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.052
• 作为产物：
  描述：

  茚满 在 sodium tetrahydroborate 、 硫酸 、 硝酸 、 对甲苯磺酸 、 间氯过氧苯甲酸 作用下， 以 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 生成 (1S,2R)-1-amino-6-nitro-2,3-dihydro-1H-inden-2-ol
  参考文献：
  名称：

  Aryl sulfonamido indane inhibitors of the Kv1.5 ion channel

  摘要：

  A collection of aryl sulfonamido indanes based on the lead compound I was synthesized and evaluated for Kv1.5 inhibitory activity. Kv1.5 inhibitors have the potential to be atrium-selective agents for treatment of atrial fibrillation. (1R,2R)-1 has an IC50 of 0.033 mu M against Kv1.5 and is selective against other cardiac ion channels, including hERG. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.052

文献信息

• TRICYCLIC CARBAMATE JAK INHIBITORS
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20140363443A1

  公开（公告）日：2014-12-11

  The present disclosure relates to 2,4-pyrimidinediamines substituted with tricyclic carbamates and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, such as JAK2 or JAK3, is therapeutically useful.

  本公开涉及用三环氨基甲酸酯取代的2,4-嘧啶二胺及其组合物和方法，用于治疗需要治疗JAK通路调节或抑制JAK激酶（如JAK2或JAK3）的情况的治疗。
• US8846908B2
  申请人：——

  公开号：US8846908B2

  公开（公告）日：2014-09-30
• Aryl sulfonamido indane inhibitors of the Kv1.5 ion channel
  作者：Michael F. Gross、Serge Beaudoin、Grant McNaughton-Smith、George S. Amato、Neil A. Castle、Christine Huang、Anruo Zou、Weifeng Yu

  DOI：10.1016/j.bmcl.2007.02.052

  日期：2007.5

  A collection of aryl sulfonamido indanes based on the lead compound I was synthesized and evaluated for Kv1.5 inhibitory activity. Kv1.5 inhibitors have the potential to be atrium-selective agents for treatment of atrial fibrillation. (1R,2R)-1 has an IC50 of 0.033 mu M against Kv1.5 and is selective against other cardiac ion channels, including hERG. (c) 2007 Elsevier Ltd. All rights reserved.