Boc-Phe-NHC2H5 | 120125-08-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Phe-NHC2H5
• 英文别名: tert-butyl N-[(2S)-1-(ethylamino)-1-oxo-3-phenylpropan-2-yl]carbamate
• CAS: 120125-08-8
• 化学式: C₁₆H₂₄N₂O₃
• 分子量: 292.378
• InChiKey: FJMPOGOKGKPDGM-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Boc-Phe-NHC2H5 在 盐酸 作用下， 反应 0.5h， 生成 H-Phe-NHC2H5*HCl
  参考文献：
  名称：

  Studies on analgesic oligopeptides. V. Structure-activity relationship of tripeptide alkylamides, Tyr-D-Arg-Phe-X.

  摘要：

  通过溶液法合成了基于结构Tyr-D-Arg-Phe-X（X=OH，烷基酯，烷基酰胺或具有不同碳链的氨基酸）的21种类似物，并在小鼠皮下（s.c.）给药后测试了它们的镇痛活性。大多数三肽烷基酰胺在10 mg/kg，s.c.剂量下没有镇痛作用。然而，一些在烷基部分具有羟基的三肽烷基酰胺显示出比吗啡更大的活性。在烷基部分引入羧基也导致具有强效镇痛作用的四肽类似物，例如，X=β-丙氨酸的化合物在摩尔基础上比吗啡强33倍。这些结果表明，适当的碳链长度和在第四位存在氧原子对于D-Arg2-dermorphin类似物系列中的高镇痛活性是重要的。

  DOI：

  10.1248/cpb.36.4834
• 作为产物：
  描述：

  BOC-L-苯丙氨酸 、 乙胺 在 N-甲基吗啉 、 氯甲酸异丁酯 作用下， 以 四氢呋喃 为溶剂， 生成 Boc-Phe-NHC2H5
  参考文献：
  名称：

  通过Red-Al还原N -Boc保护的氨基酸衍生的仲酰胺有效制备手性二胺

  摘要：

  已经开发了选择性还原N -Boc保护的氨基酸衍生的仲酰胺的条件，从而避免了过度还原和环状脲副产物的形成。NK-1拮抗剂LY303870的有效形式合成证明了该方法。

  DOI：

  10.1016/j.tetlet.2006.01.056

文献信息

• [EN] DERIVATIVES OF DOLASTATIN 10 AND USES THEREOF<br/>[FR] DÉRIVÉS DE DOLASTATINE 10 ET UTILISATIONS DE CEUX-CI
  申请人：NEWBIO THERAPEUTICS INC

  公开号：WO2016192527A1

  公开（公告）日：2016-12-08

  Derivatives of dolastatin 10 and uses thereof, the structures of which are shown as formula I, II, III and IV are provided.

  多拉司丁10衍生物及其用途，其结构如公式I、II、III和IV所示。
• NOVEL REACTIVE ALGINIC ACID DERIVATIVES
  申请人：Mochida Pharmaceutical Co., Ltd.

  公开号：EP3778653A1

  公开（公告）日：2021-02-17

  The present invention provides alginic acid derivatives having a group represented by general formula (I) or general formula (II) (the right side of the dashed line is excluded in each formula) at a portion of the carboxyl groups in an alginic acid. Novel alginic acid derivatives are thereby provided.

  本发明提供的海藻酸衍生物在海藻酸的部分羧基上具有通式(I)或通式(II)所代表的基团（各式中均不包括虚线右侧）。由此提供了新型藻酸衍生物。
• Direct Joining of a Heterogeneous Pair of Supramolecular Nanotubes and Reaction Control of a Guest Compound by Transportation in the Nanochannels
  作者：Naohiro Kameta、Wuxiao Ding

  DOI：10.1246/bcsj.20190046

  日期：2019.6.15

  Abstract Four novel amino-acid lipids were synthesized and then self-assembled in water to produce four different types of supramolecular nanotubes. The nanotubes consisted of a single monolayer of amino-acid lipids packed in parallel and had similar inner diameters and membrane wall thicknesses but dissimilarly charged surfaces. Mixing of nanotubes that had cationic exterior surfaces with nanotubes that had anionic exterior surfaces resulted in aggregation of the nanotubes. In contrast, mixing of nanotubes with cationic interior surfaces and nanotubes with anionic interior surfaces resulted in end-to-end joining of the two types of nanotubes via electrostatic attractions at the open ends to form heterogeneous nanotubes. Time-lapse fluorescence microscopy confirmed that a fluorophore could be transported through the heterogeneous nanotubes, which had alternating acidic and basic nanochannel segments. In addition, acid–base reactions of the fluorophore could be precisely controlled during transport. This nanotube-joining technique should be useful not only for the construction of multifunctional hybrid nanotubes but also for the production of nanoreactors for chemical/biological reactions and nanodevices for analysis and separation.
• SUZUKI, KENJI;FUJITA, HIROKI;SASAKI, YUSUKE;SHIRATORI, MIKI;SAKURADA, SHI+, CHEM. AND PHARM. BULL., 36,(1988) N2, C. 4834-4840
  作者：SUZUKI, KENJI、FUJITA, HIROKI、SASAKI, YUSUKE、SHIRATORI, MIKI、SAKURADA, SHI+

  DOI：——

  日期：——
• US6953788B1
  申请人：——

  公开号：US6953788B1

  公开（公告）日：2005-10-11