5-(O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)hydroxymethyl)-5-(N-(benzyloxycarbonyl)sarcosinamido)-2-phenyl-1,3-dioxane | 170124-34-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-(O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)hydroxymethyl)-5-(N-(benzyloxycarbonyl)sarcosinamido)-2-phenyl-1,3-dioxane
• CAS: 170124-34-2
• 化学式: C₃₆H₄₄N₂O₁₅
• 分子量: 744.75
• InChiKey: MVWHSDYNPXCZDP-VVKKWFLJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.96
• 重原子数：
  53.0
• 可旋转键数：
  14.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  200.76
• 氢给体数：
  1.0
• 氢受体数：
  15.0

反应信息

• 作为反应物：
  描述：

  5-(O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)hydroxymethyl)-5-(N-(benzyloxycarbonyl)sarcosinamido)-2-phenyl-1,3-dioxane 在 palladium on activated charcoal 4-二甲氨基吡啶 、 氢气 、 sodium methylate 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 8.0h， 生成
  参考文献：
  名称：

  Vesicles and other supramolecular systems made from double-tailed synthetic glycolipids derived from galactosylated tris(hydroxymethyl)aminomethane

  摘要：

  A series of double-tailed hydrocarbon glycolipids derived from tris(hydroxymethyl)aminomethane (Tris) have been prepared. These amphiphiles consist of three parts: a hydrophilic head derived from mono- or polygalactosylated Tris, a linking arm of peptidic nature and a hydrophobic double tail composed of 12 or 18 carbon atom chains. The ability of the new glycolipids to disperse in water, the morphology of the self-assemblies they form and the stability of the latter were shown to depend largely on the volumetric ratio between hydrophilic head and hydrophobic tails. Comparative studies of such substrates allowed a better understanding of the relative role of the various parameters that govern the formation of tubular systems relative to vesicular organizations. In all cases, the introduction of oligomeric galactosylated heads favoured stable vesicular systems over tubules.

  DOI：

  10.1016/0009-3084(95)02475-x
• 作为产物：
  描述：

  N-(benzyloxycarbonyl)sarcosyl tris(hydroxymethyl)aminomethane 在 calcium sulfate 、 氰化汞 、 对甲苯磺酸 作用下， 以 乙腈 为溶剂， 反应 24.0h， 生成 5-(O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)hydroxymethyl)-5-(N-(benzyloxycarbonyl)sarcosinamido)-2-phenyl-1,3-dioxane
  参考文献：
  名称：

  Vesicles and other supramolecular systems made from double-tailed synthetic glycolipids derived from galactosylated tris(hydroxymethyl)aminomethane

  摘要：

  A series of double-tailed hydrocarbon glycolipids derived from tris(hydroxymethyl)aminomethane (Tris) have been prepared. These amphiphiles consist of three parts: a hydrophilic head derived from mono- or polygalactosylated Tris, a linking arm of peptidic nature and a hydrophobic double tail composed of 12 or 18 carbon atom chains. The ability of the new glycolipids to disperse in water, the morphology of the self-assemblies they form and the stability of the latter were shown to depend largely on the volumetric ratio between hydrophilic head and hydrophobic tails. Comparative studies of such substrates allowed a better understanding of the relative role of the various parameters that govern the formation of tubular systems relative to vesicular organizations. In all cases, the introduction of oligomeric galactosylated heads favoured stable vesicular systems over tubules.

  DOI：

  10.1016/0009-3084(95)02475-x