12-(4-fluorophenyl)-8,9,10,12-tetrahydro-7H-benzo[b][4,7]phenanthrolin-11-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 12-(4-fluorophenyl)-8,9,10,12-tetrahydro-7H-benzo[b][4,7]phenanthrolin-11-one
• 英文别名: 12-(4-fluorophenyl)-9,10-dihydrobenzo[b][4,7]phenanthrolin-11(7H,8H,12H)-one
• 化学式: C₂₂H₁₇FN₂O
• 分子量: 344.388
• InChiKey: PGAJBYMUKCCHKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对氟苯甲醛 以 乙醇 为溶剂， 反应 3.0h， 生成 12-(4-fluorophenyl)-8,9,10,12-tetrahydro-7H-benzo[b][4,7]phenanthrolin-11-one
  参考文献：
  名称：

  Condensation of fluorosubstituted benzaldehydes with amines and cyclic 1,3-diketones

  摘要：

  Condensation of fluorosubstituted benzaldehydes with 2-naphthyl or 6-quinolylamine and cyclic beta-diketones (,3-cyclohexanedione, dimedone, and 1,3-indandione) provided new fluoroderivatives of benzo[a]acridine, 4,7-phenanthroline, and benzo[f]indeno[1,2-b]quinoline. Forming in the course of the reaction fluorophenylmethylene-2-naphthyl-(or 6-quinolyl)amines, arylbis(cyclohexane-1,3-dion-2-yl)methanes, and 2-(fluorophenylmethylene)- 1,3-indandiones were isolated.

  DOI：

  10.1134/s107042800611011x

文献信息

• An efficient and facile microwave‐assisted synthesis of benzo[ <i>b</i> ][4,7]phenanthroline derivatives in water
  作者：Feng Shi、Dianxiang Zhou、Chunmei Li、Qingqing Shao、Longji Cao、Shujiang Tu

  DOI：10.1002/jhet.5570450217

  日期：2008.3

  A series of benzo[b][4,7]phenanthroline derivatives were synthesized via a three-component reaction of aromatic aldehydes, 6-aminoquinoline and either 1,3-cyclohexanedione or dimedone in water under microwave irradiation without use of any catalyst. This method has the advantages of short reaction time, high yields, low cost and environmental friendliness as well as easy operation.

  一系列的苯并[ b ] [4,7]菲咯啉衍生物的合成通过芳香醛的三组分反应，6-氨基喹啉，要么在微波辐射下在水中的1,3-环己二酮或双甲酮在不使用任何催化剂。该方法具有反应时间短，收率高，成本低，环境友好，操作简便的优点。
• Condensation of fluorosubstituted benzaldehydes with amines and cyclic 1,3-diketones
  作者：N. G. Kozlov、K. N. Gusak

  DOI：10.1134/s107042800611011x

  日期：2006.11

  Condensation of fluorosubstituted benzaldehydes with 2-naphthyl or 6-quinolylamine and cyclic beta-diketones (,3-cyclohexanedione, dimedone, and 1,3-indandione) provided new fluoroderivatives of benzo[a]acridine, 4,7-phenanthroline, and benzo[f]indeno[1,2-b]quinoline. Forming in the course of the reaction fluorophenylmethylene-2-naphthyl-(or 6-quinolyl)amines, arylbis(cyclohexane-1,3-dion-2-yl)methanes, and 2-(fluorophenylmethylene)- 1,3-indandiones were isolated.