cyclohexa-3,5-diene-1,2,4-triol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cyclohexa-3,5-diene-1,2,4-triol
• 英文别名: Dihydrohydroxyhydroquinone
• 化学式: C₆H₈O₃
• 分子量: 128.128
• InChiKey: SLJVVKBHGAXDME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  亚甲兰 在 Cu_0.04Ni_0.96MoO₄ 作用下， 以 水 为溶剂， 反应 3.0h， 生成 cyclohexa-3,5-diene-1,2,4-triol 、 5-氨基-2-羟基苯磺酸 、 3,7-diamino-10H-phenothiazine 5-oxide 、 3,7-bis(dimethylamino)-10H-phenothiazine 5-oxide 、 3,7-bis(methyl amino)-10H-phenothiazine 5-oxide 、 、 亚甲基蓝阳离子 、 Azure B 、 3-氨基苯磺酸 、 苯酚
  参考文献：
  名称：

  Cu-α-NiMoO4 photocatalyst for degradation of Methylene blue with pathways and antibacterial performance

  摘要：

  Cu doped alpha-NiMoO4 photocatalyst has been synthesized by microwave hydrothermal method. The existence of Cu2+ ions at lattice position of alpha-NiMoO4 was observed on the basis of XRD, HRTEM, SAED, and EDS analysis. The negative zeta potential values indicate the stability of samples. Solar light driven photocatalytic degradation of Methylene blue (MB) dye in water was used to evaluate the photocatalytic performance of Cu doped alpha-NiMoO4 photocatalyst. The results revealed that there is an optimum Cu (4 mol%) doping level leads to highly enhanced photocatalytic activity of Cu-alpha-NiMoO4, as compared to alpha-NiMoO4 host. The experiment also suggested that active species (OH center dot, O-2(center dot-) and h(+)) play a crucial role in the scavenging system. The reduced energy band gap, oxygen vacancy, high BET surface area, and efficient separation of photogenerated electron/hole are responsible for enhancement of photocatalytic performance. MB photodegradation intermediates were identified by high resolution-quadruple time of flight electrospray ionization mass spectrometry (HR-QTOF ESI/MS) in positive ion mode and degradation pathway was proposed. Antibacterial performance was analyzed against Gram-positive (methicillin resistant Staphylococcus aureus and Bacillus Subtilis) and Gram-negative bacteria (Pseudomonas aeruginosa) via well-diffusion method. The formation of larger inhibition zone by small quantity of photocatalyst powder proved the excellent antibacterial performance. The inactivation of microorganism were found in following order: B.Subtilis > S.aureus > P.aeruginosa. The result of our study suggested that copper doped alpha-NiMoO4 photocatalyst is suitable for degradation of organic contaminates as well as effective for growth inhibition of multidrug-resistant microorganisms. (C) 2017 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jphotochem.2017.08.004

文献信息

• Piperidine and piperazine carboxylates as FAAH inhibitors
  申请人：Astellas Pharma Inc.

  公开号：EP2607362A1

  公开（公告）日：2013-06-26

  [Problem] To provide a compound usable for treatment of diseases associated with fatty acid amide hydrolase (FAAH), especially for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain. [Means for Solution] We have found that a novel pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative and its pharmaceutically acceptable salt has a potent FAAH-inhibitory activity. Further, the pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivative of the present invention has an excellent effect for increasing an effective bladder capacity, an excellent effect for relieving urinary frequency and an excellent anti-allodynia effect, and is therefore usable for treatment of urinary frequency and urinary incontinence, overactive bladder and/or pain.

  [问题]提供一种可用于治疗与脂肪酸酰胺水解酶（FAAH）相关疾病的化合物，特别是用于治疗尿频和尿失禁、膀胱过度活动症和/或疼痛。 [解决方法]我们发现，一种新型吡啶基非芳香族含氮杂环-1-羧酸酯衍生物及其药学上可接受的盐具有强效的 FAAH 抑制活性。此外，本发明的吡啶基非芳香族含氮杂环-1-羧酸酯衍生物在增加有效膀胱容量方面效果显著，在缓解尿频方面效果显著，在抗排尿障碍方面效果显著，因此可用于治疗尿频和尿失禁、膀胱过度活动症和/或疼痛。
• Cu-α-NiMoO4 photocatalyst for degradation of Methylene blue with pathways and antibacterial performance
  作者：Schindra Kumar Ray、Dipesh Dhakal、Yuwaraj K. Kshetri、Soo Wohn Lee

  DOI：10.1016/j.jphotochem.2017.08.004

  日期：2017.11

  Cu doped alpha-NiMoO4 photocatalyst has been synthesized by microwave hydrothermal method. The existence of Cu2+ ions at lattice position of alpha-NiMoO4 was observed on the basis of XRD, HRTEM, SAED, and EDS analysis. The negative zeta potential values indicate the stability of samples. Solar light driven photocatalytic degradation of Methylene blue (MB) dye in water was used to evaluate the photocatalytic performance of Cu doped alpha-NiMoO4 photocatalyst. The results revealed that there is an optimum Cu (4 mol%) doping level leads to highly enhanced photocatalytic activity of Cu-alpha-NiMoO4, as compared to alpha-NiMoO4 host. The experiment also suggested that active species (OH center dot, O-2(center dot-) and h(+)) play a crucial role in the scavenging system. The reduced energy band gap, oxygen vacancy, high BET surface area, and efficient separation of photogenerated electron/hole are responsible for enhancement of photocatalytic performance. MB photodegradation intermediates were identified by high resolution-quadruple time of flight electrospray ionization mass spectrometry (HR-QTOF ESI/MS) in positive ion mode and degradation pathway was proposed. Antibacterial performance was analyzed against Gram-positive (methicillin resistant Staphylococcus aureus and Bacillus Subtilis) and Gram-negative bacteria (Pseudomonas aeruginosa) via well-diffusion method. The formation of larger inhibition zone by small quantity of photocatalyst powder proved the excellent antibacterial performance. The inactivation of microorganism were found in following order: B.Subtilis > S.aureus > P.aeruginosa. The result of our study suggested that copper doped alpha-NiMoO4 photocatalyst is suitable for degradation of organic contaminates as well as effective for growth inhibition of multidrug-resistant microorganisms. (C) 2017 Elsevier B.V. All rights reserved.