5-(6-chloro-1-hexyloxy)-2-(4-hydroxyphenyl)pyrimidine | 1221433-09-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(6-chloro-1-hexyloxy)-2-(4-hydroxyphenyl)pyrimidine
• CAS: 1221433-09-5
• 化学式: C₁₆H₁₉ClN₂O₂
• 分子量: 306.792
• InChiKey: UVWIQDHBXXHWDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.03
• 重原子数：
  21.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  55.24
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  5-(6-chloro-1-hexyloxy)-2-(4-hydroxyphenyl)pyrimidine 、 11-(1,1,1,3,3,5,5-heptamethyltrisiloxanyl)-undecanol 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以51%的产率得到5-(6-chloro-1-hexyloxy)-2-(4-(11-(1,1,1,3,3,5,5-heptamethyltrisiloxanyl)undecyloxy)phenyl)pyrimidine
  参考文献：
  名称：

  Design of Liquid Crystals with “de Vries-like” Properties: Frustration between SmA- and SmC-Promoting Elements

  摘要：

  According to a new design strategy for "de Vries-like" liquid crystal materials, which are characterized by a maximum layer contraction of <= 1% upon transition from the SmA phase to the SmC phase, we report the synthesis and characterization of two homologous series of organosiloxane mesogens. The design of these new materials is based on a frustration between one structural element that promotes the formation of a SmC phase (a trisiloxane-terminated side-chain) and one that promotes the formation of a SmA phase (either a chloro-terminated side-chain or a 5-phenylpyrimidine core). Measurements of smectic layer spacing d as a function of temperature by small-angle X-ray scattering (SAXS) combined with optical tilt angle measurements revealed that the mesogens 5-(4-(11-(1,1,1,3,3,5,5-heptamethyltrisiloxanyl)-undecyloxy)phenyl)-2-(1-alkyloxy)pyrimidine (3(n)) undergo SmA-SmC phase transitions with maximum layer contractions ranging from 0.5% to 1.4%. A comparison of reduction factors R and f suggests that this behavior is due in part to a pronounced negative thermal expansion in the SmC phase that counterbalances the layer contraction caused by increasing tilt. SAXS measurements also revealed that compounds 3(n) are characterized by low orientational and high translational order, which is consistent with theoretical predictions that such materials should exhibit de Vries-like properties. The R values for series 3(n) are comparable to, and even lower than, those reported for established de Vries-like materials such as the perfluorinated 2-phenylpyrimidine material 3M 8422.

  DOI：

  10.1021/ja9087727
• 作为产物：
  描述：

  6-氯-1-己醇 、 2-（4-羟基苯基）-5-嘧啶醇 在 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以61%的产率得到5-(6-chloro-1-hexyloxy)-2-(4-hydroxyphenyl)pyrimidine
  参考文献：
  名称：

  Design of Liquid Crystals with “de Vries-like” Properties: Frustration between SmA- and SmC-Promoting Elements

  摘要：

  According to a new design strategy for "de Vries-like" liquid crystal materials, which are characterized by a maximum layer contraction of <= 1% upon transition from the SmA phase to the SmC phase, we report the synthesis and characterization of two homologous series of organosiloxane mesogens. The design of these new materials is based on a frustration between one structural element that promotes the formation of a SmC phase (a trisiloxane-terminated side-chain) and one that promotes the formation of a SmA phase (either a chloro-terminated side-chain or a 5-phenylpyrimidine core). Measurements of smectic layer spacing d as a function of temperature by small-angle X-ray scattering (SAXS) combined with optical tilt angle measurements revealed that the mesogens 5-(4-(11-(1,1,1,3,3,5,5-heptamethyltrisiloxanyl)-undecyloxy)phenyl)-2-(1-alkyloxy)pyrimidine (3(n)) undergo SmA-SmC phase transitions with maximum layer contractions ranging from 0.5% to 1.4%. A comparison of reduction factors R and f suggests that this behavior is due in part to a pronounced negative thermal expansion in the SmC phase that counterbalances the layer contraction caused by increasing tilt. SAXS measurements also revealed that compounds 3(n) are characterized by low orientational and high translational order, which is consistent with theoretical predictions that such materials should exhibit de Vries-like properties. The R values for series 3(n) are comparable to, and even lower than, those reported for established de Vries-like materials such as the perfluorinated 2-phenylpyrimidine material 3M 8422.

  DOI：

  10.1021/ja9087727