2-methoxy-2-methylheptane | 76589-16-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methoxy-2-methylheptane
• CAS: 76589-16-7
• 化学式: C₉H₂₀O
• 分子量: 144.257
• InChiKey: KJRACWZCOVHBQU-UHFFFAOYSA-N

物化性质

• 沸点：
  160.5℃ at 101.6kPa
• 密度：
  0.793 at 20℃
• LogP：
  3.7 at 25℃

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6-甲基-5-庚烯-2-酮 在 硫酸 、 一水合肼 、 potassium hydroxide 作用下， 以 二乙二醇 为溶剂， 反应 9.5h， 生成 2-methoxy-2-methylheptane
  参考文献：
  名称：

  [EN] NEW METHOD FOR SYNTHESIS OF 2-METHYL-2-HYDROXYHEPTANE AND 2-METHYL 2-ALKOXYHEPTANES
  [FR] NOUVEAU PROCÉDÉ DE SYNTHÈSE DE 2-MÉTHYL-2-HYDROXYHEPTANE ET DE 2-MÉTHYL-2-ALCOXYHEPTANES

  摘要：

  The present disclosure pertains to a new synthetic method for the preparation of 2-methyl-2-hydroxyheptane and 2-methyl-2-alkoxyheptanes, which are valuable commodities for use in flavors, fragrances and various personal care products, such as cosmetics.

  公开号：

  WO2022076892A1

文献信息

• [EN] QUINOXALINE-CONTAINING COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS<br/>[FR] COMPOSÉS CONTENANT DE LA QUINOXALINE EN TANT QU'INHIBITEURS DU VIRUS DE L'HÉPATITE C
  申请人：ENANTA PHARM INC

  公开号：WO2009064975A1

  公开（公告）日：2009-05-22

  The present invention discloses compounds of formula I and II or pharmaceutically acceptable salts, esters, or prodrugs thereof which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了抑制丝氨酸蛋白酶活性的I和II公式化合物，或其药物可接受的盐、酯或前药，尤其是抑制丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，并且也用作抗病毒剂。本发明进一步涉及包含前述化合物的药物组合物，用于给患有HCV感染的主体进行管理。本发明还涉及通过管理包含本发明化合物的药物组合物来治疗主体中的HCV感染的方法。
• [EN] FRAGRANCE AND FLAVOR MATERIALS<br/>[FR] MATÉRIAUX DE PARFUM ET D'ARÔME
  申请人：TAKASAGO INT CORPORATION USA

  公开号：WO2018119466A1

  公开（公告）日：2018-06-28

  The present disclosure is directed to the synthesis and application of undecavertol derivatives having unique and desired flavor and/or fragrant characteristics. The compounds of the present disclosure can be employed alone or incorporated as fragrance or flavor ingredients in fragrance or flavor compositions. The present disclosure is also directed to consumer products comprising such derivatives and/or fragrance or flavor compositions.

  本公开涉及合成和应用具有独特和理想风味和/或芳香特性的十一萜醇衍生物。本公开的化合物可以单独应用，也可以作为香精或风味成分并入香精或风味配方中。本公开还涉及包含这些衍生物和/或香精或风味配方的消费者产品。
• [EN] FRAGRANCE AND FLAVOR MATERIALS<br/>[FR] MATI ÈRES DE PARFUM ET D'ARÔME
  申请人：TAKASAGO INT CORPORATION USA

  公开号：WO2018119471A1

  公开（公告）日：2018-06-28

  The present disclosure is directed to the synthesis and application of ethyl linalool derivatives having unique and desired flavor and/or fragrance characteristics. The compounds of the present disclosure can be employed alone or incorporated as fragrance or flavor ingredients in fragrance or flavor compositions. The present disclosure is also directed to consumer products comprising such derivatives and/or fragrance or flavor compositions.

  本公开涉及合成和应用具有独特和理想风味和/或香味特性的乙基香叶醇衍生物。本公开的化合物可以单独使用，也可以作为香味或风味成分纳入香味或风味组合物中。本公开还涉及包含这种衍生物和/或香味或风味组合物的消费者产品。
• Nucleophilic Alkoxylations of Unactivated Alkyl Olefins and α‐Methyl Styrene by Photoredox Catalysis
  作者：Fabienne Seyfert、Mathis Mitha、Hans‐Achim Wagenknecht

  DOI：10.1002/ejoc.202001533

  日期：2021.2.5

  The photoredox catalytic addition of alcohols to non‐activated terminal alkyl olefins is obtained by the use of N,N‐diisobutylamino‐phenylphenothiazine. Its excited state redox potential is sufficiently high to promote the photoreduction.

  通过使用N，N-二异丁基氨基-苯基吩噻嗪可以将醇类光氧化还原催化加成到未活化的末端烷基烯烃上。其激发态氧化还原电势足够高以促进光还原。
• CB2-selective cannabinoid analogues
  申请人：Martin R. Billy

  公开号：US20050009903A1

  公开（公告）日：2005-01-13

  Cannabinoid analogues that exhibit specificity for the CB 2 cannabinoid receptor are provided. The analogues are 1-methoxy-, 1-deoxy-11-hydroxy- and 11-hydroxy-1-methoxy-Δ 8 -tetrahydrocannabinols and 1-alkyl-3(1-naphthoyl)indoles. The compounds are useful for the treatment of pain (especially pain resulting from inflammation) and cancer (especially glioma tumors).

  提供了对CB2大麻素受体具有特异性的大麻素类似物。这些类似物是1-甲氧基-、1-去氧-11-羟基-和11-羟基-1-甲氧基-Δ8-四氢大麻酚以及1-烷基-3(1-萘酰)吲哚。这些化合物对于治疗疼痛（尤其是由炎症引起的疼痛）和癌症（尤其是胶质瘤）具有用途。