2-sec-butylindole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-sec-butylindole
• 英文别名: 2-butan-2-yl-1H-indole
• 化学式: C₁₂H₁₅N
• 分子量: 173.258
• InChiKey: NCROCYRINMLLDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-sec-butylindole 在 lithium aluminium tetrahydride 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-sec-butyltryptamine
  参考文献：
  名称：

  Deconstruction of the α4β2 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator Desformylflustrabromine

  摘要：

  Desformylflustrabromine (dFBr; 1), perhaps the first selective positive allosteric modulator of alpha 4 beta 2 neuronal nicotinic acetylcholine (nACh) receptors, was deconstructed to determine which structural features contribute to its actions on receptors expressed in Xenopus ooycytes using two-electrode voltage clamp techniques. Although the intact structure of 1 was found to be optimal, several deconstructed analogs retained activity. Neither the 6-bromo substituent nor the entire 2-position chain is required for activity. In particular, reduction of the olefinic side chain of 1, as seen with 6, not only resulted in retention of activity/potency but in enhanced selectivity for alpha 4 beta 2 versus alpha 7 nACh receptors. Pharmacophoric features for the allosteric modulation of alpha 4 beta 2 nACh receptors by 1 were identified.

  DOI：

  10.1021/jm200834x
• 作为产物：
  描述：

  2-乙基吲哚 、 甲丁醚 在 正丁基锂 、 potassium tert-butylate 作用下， 以 正己烷 为溶剂， 以59%的产率得到2-sec-butylindole
  参考文献：
  名称：

  Ethylation of the Indole Dianions by Alkyl Methyl Ethers

  摘要：

  DOI：

  10.1021/jo00131a004

文献信息

• [EN] COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME<br/>[FR] COMPOSITIONS PERMETTANT DE FAVORISER LA TRANSLECTURE DE CODONS DE TERMINAISON PRÉMATURÉE, ET LEURS PROCÉDÉS D'UTILISATION
  申请人：THE CENTRE FOR DRUG RES AND DEV

  公开号：WO2017049409A1

  公开（公告）日：2017-03-30

  Disclosed are compounds of general formula (I) that promote readthrough of a premature termination codon (PTC) of an RNA molecule in a translation system, and their use, alone or in combination with other compounds, such as aminoglycoside, to treat diseases or disorders ameliorated by modulation of a premature termination codon (PTC) of an RNA molecule in a translation system. The disorder or disease may be Dystrophic epidermolysis bullosa, Batten disease, Duchenne muscular dystrophy, cancer, and spinal muscular atrophy. Ar-L-B (I)

  公开了通式(I)的化合物，它们能够促进RNA分子在翻译系统中过早终止密码子(PTC)的通读，以及它们单独或与其他化合物如氨基糖苷的组合使用，用于治疗通过调节翻译系统中RNA分子的过早终止密码子(PTC)而得到改善的疾病或失调。该疾病或失调可能是营养不良性表皮松解症、贝敦病、杜氏肌营养不良症、癌症和脊髓性肌萎缩症。Ar-L-B (I)
• [EN] RSV POLYMERASE INHIBITORS<br/>[FR] INHIBITEURS POLYMERASE RSV
  申请人：BOEHRINGER INGELHEIM CA LTD

  公开号：WO2005042530A1

  公开（公告）日：2005-05-12

  Compounds or enantiomers of formula (I) or a salt thereof: wherein R1, R2, R3, R4 and R5 are as defined herein, are useful for the manufacture of a medicament for the treatment or prevention of respiratory syncytial virus infection in a mammal.

  化合物或式(I)的对映体或盐：其中R1、R2、R3、R4和R5如本文所定义，可用于制造用于治疗或预防哺乳动物呼吸道合胞病毒感染的药物。
• [EN] PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AGONISTS, METHOD OF PREPARATION AND USES THEREOF<br/>[FR] AGONISTES DU RÉCEPTEUR GAMMA ACTIVÉ PAR LES PROLIFÉRATEURS DES PEROXYSOMES, LEUR PROCÉDÉ DE PRÉPARATION ET LEURS UTILISATIONS
  申请人：UNIV D'AIX-MARSEILLE

  公开号：WO2018011230A1

  公开（公告）日：2018-01-18

  The present invention relates to new peroxisome proliferator-activated receptor gamma (PPARϒ) agonists, and their uses as in the prevention and/or treatment of type 2 diabetes, impaired glucose tolerance, insulin resistance syndrome, hyperlipidemia, metabolic syndrome, visceral obesity, obesity, hyperlipidemia and hypertriglyceridemia. The preparation said compounds is also described.

  本发明涉及新的过氧化物酶增殖物激活受体γ（PPARϒ）激动剂，以及它们在预防和/或治疗2型糖尿病、糖耐量受损、胰岛素抵抗综合征、高脂血症、代谢综合征、内脏肥胖、肥胖、高脂血症和高甘油三酯血症方面的用途。还描述了制备这些化合物的方法。
• A facile one-pot method to synthesise 2-alkylated indole and 2,2′-bis(indolyl)methane derivatives using ketones as electrophiles and their anion sensing ability
  作者：Sinan Bayindir、Nurullah Saracoglu

  DOI：10.1039/c6ra16192h

  日期：——

  Indole derivatives are of great importance because of their biological activity and application in technology. This study explores the synthesis of 2-alkylated indoles derivatives and 2,2′-bis(indolyl)methanes, and their application in anion sensing. The synthesis of a wide range of 2-alkylated indoles and some 2,2′-bis(indolyl)methanes, which cannot be synthesized by previously reported methods, was

  吲哚衍生物由于其生物活性和在技术中的应用而具有重要意义。这项研究探索2-烷基化的吲哚衍生物和2,2'-双（吲哚基）甲烷的合成及其在阴离子传感中的应用。不能通过先前报道的方法合成的范围广泛的2-烷基化的吲哚和一些2,2'-双（吲哚基）甲烷的合成是首次使用吲哚环向亲电取代的偶极交换来完成的。某些吲哚衍生物表现出选择性识别和感测能力朝˚F -和HSO 4 -通过肉眼检测的颜色变化的阴离子。还使用UV-Vis光谱和1对吲哚衍生物的感测细节进行了评估1 H NMR滴定技术。
• Dihydroxypyrimidine carboxamide inhibitors of HIV integrase
  申请人：Di Francesco E. Maria

  公开号：US20070083045A1

  公开（公告）日：2007-04-12

  4,5-Dihydroxypyrimidine-6-carboxamides of formula: are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein R 1 , R 2 , R 3 and R 4 are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

  本文描述了式子中R1，R2，R3和R4被定义的4,5-二羟基嘧啶-6-羧酰胺化合物，其作为HIV整合酶抑制剂和HIV复制抑制剂。这些化合物对于预防和治疗HIV感染以及预防、延迟AIDS发病和治疗AIDS非常有用。这些化合物可以作为化合物本身或药物可接受的盐形式用于对抗HIV感染和AIDS。这些化合物及其盐可以与其他抗病毒药物、免疫调节剂、抗生素或疫苗组合使用，作为制药组合物的成分。本文还描述了预防、治疗或延迟AIDS发病以及预防或治疗HIV感染的方法。