2,3-dimethoxy-cinnamic acid ethyl ester | 39059-72-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2,3-dimethoxy-cinnamic acid ethyl ester
• 英文别名: 2,3-Dimethoxy-zimtsaeure-aethylester；Ethyl 3-(2,3-dimethoxyphenyl)prop-2-enoate；ethyl 3-(2,3-dimethoxyphenyl)prop-2-enoate
• CAS: 39059-72-8
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: ZRPIWXVGAWRSMB-UHFFFAOYSA-N

物化性质

• 熔点：
  45-46 °C(Solvent: Ethanol)
• 沸点：
  184-185 °C(Press: 15 Torr)
• 密度：
  1.099±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,3-dimethoxy-cinnamic acid ethyl ester 在 二硫化碳 、 溴 作用下， 生成 2,3-Dimethoxyphenyl-propargylsaeure
  参考文献：
  名称：

  Ruhemann, Chemische Berichte, 1920, vol. 53, p. 280

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-二甲氧基苯甲醛 在 盐酸 、 sodium acetate 作用下， 生成 2,3-dimethoxy-cinnamic acid ethyl ester
  参考文献：
  名称：

  Dexamethasone prophylaxis of nausea and vomiting after epidural morphine for post-Cesarean analgesia

  摘要：

  Purpose: To determine the minimum effective dose of dexamethasone in preventing nausea and vomiting associated with epidural morphine for post-Cesarean analgesia.Method: One hundred and eighty parturients (n=45 in each of four groups) requiring epidural morphine for post Cesarean analgesia were enrolled in this randomized, double blinded, placebo-controlled study. At the end of surgery, parturients received either dexamethasone, at doses of 10 mg, 5 mg, 2.5 mg, or saline iv. Three milligrams epidural morphine were given to all parturients for postoperative analgesia, The incidence of PONV and side effects were estimated for 24 hr after delivery by blinded, trained nurse anesthetists.Results: Parturients who received dexamethasone, either 10 mg or 5 mg were different from those who received saline alone in the following parameters: the total incidence of nausea and vomiting, incidence of > 4 vomiting episodes, number the of parturients requiring rescue antiemetics, and the total number of parturients with no vomiting and/or no antiemetic medication (P < 0.05 to P < 0.01 ), The differences between dexamethasone 10 mg and 5 mg were not significant. Dexamethasone 2.5 mg was partially effective.Conclusion: Dexamethasone, 5 mg iv, is suggested as the minimum effective dose in preventing nausea and vomiting associated with epidural morphine for post-Cesarean analgesia.

  DOI：

  10.1007/bf03019733

文献信息

• S,O-Ligand-Promoted Palladium-Catalyzed C–H Functionalization Reactions of Nondirected Arenes
  作者：Kananat Naksomboon、Carolina Valderas、Melania Gómez-Martínez、Yolanda Álvarez-Casao、M. Ángeles Fernández-Ibáñez

  DOI：10.1021/acscatal.7b02356

  日期：2017.9.1

  Pd(II)-catalyzed C–H functionalization of nondirected arenes has been realized using an inexpensive and easily accessible type of bidentate S,O-ligand. The catalytic system shows high efficiency in the C–H olefination reaction of electron-rich and electron-poor arenes. This methodology is operationally simple, scalable, and can be used in late-stage functionalization of complex molecules. The broad

  Pd（II）催化的非定向芳烃的C–H功能化已通过使用廉价且易于获得的双齿S，O-配体实现。催化体系在富电子和贫电子的芳烃的C–H烯化反应中显示出很高的效率。这种方法操作简单，可扩展，可用于复杂分子的后期功能化。该催化剂的广泛适用性已在其他转化中得到了证明，例如Pd（II）催化的C–H乙酰氧基化和烯丙基化反应。
• Rate acceleration of organic reaction by immediate solvent evaporation
  作者：Akihiro Orita、Genta Uehara、Kai Miwa、Junzo Otera

  DOI：10.1039/b609567d

  日期：——

  Several types of organic reactions were accelerated by immediate evaporation of solvents because of remarkable enhancement of molecule-to-molecule contacts between reactants.

  由于显着提高了反应物之间的分子与分子之间的接触，可通过立即蒸发溶剂来加速几种类型的有机反应。
• Synthesis of Some Phenylpropanoid Glycosides (PPGs) and Their Acetylcholinesterase/Xanthine Oxidase Inhibitory Activities
  作者：Xiao-Dong Li、Shuai-Tao Kang、Guo-Yu Li、Xian Li、Jin-Hui Wang

  DOI：10.3390/molecules16053580

  日期：——

  In this research, three categories of phenylpropanoid glycosides (PPGs) were designed and synthesized with PPGs isolated from Rhodiola rosea L. as lead compounds. Their inhibitory abilities toward acetylcholinesterase (AChE) and xanthine oxidase (XOD) were also tested. Some of the synthetic PPGs exhibited excellent enzyme inhibitory abilities.

  在这项研究中，设计和合成了三类苯丙素糖苷（PPGs），以从红景天中分离的PPGs作为先导化合物。同时测试了它们对乙酰胆碱酯酶（AChE）和黄嘌呤氧化酶（XOD）的抑制能力。部分合成PPGs表现出了优异的酶抑制能力。