2-[4-(chloromethyl)phenoxy]pyrimidine | 725232-09-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[4-(chloromethyl)phenoxy]pyrimidine
• CAS: 725232-09-7
• 化学式: C₁₁H₉ClN₂O
• 分子量: 220.658
• InChiKey: CDGNNFYCLMOZEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[4-(chloromethyl)phenoxy]pyrimidine 、 4-氧代哌啶酮盐酸盐 在 N,N-二异丙基乙胺 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 生成 1-[(4-pyrimidin-2-yloxyphenyl)methyl]piperidin-4-one
  参考文献：
  名称：

  [EN] N-SUBSTITUTED AZACYCLES
  [FR] AZACYCLES N-SUBSTITUES

  摘要：

  公开号：

  WO2005036961A3
• 作为产物：
  描述：

  (4-pyrimidin-2-yloxyphenyl)methan-1-ol 在 吡啶 、 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 2-[4-(chloromethyl)phenoxy]pyrimidine
  参考文献：
  名称：

  [EN] N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL) PIPERIDINES AND PYRIDINES
  [FR] N-(ARYLMETHYL SUBSTITUE)-4-(METHYL DISUBSTITUE) PIPERIDINES ET PYRIDINES ASSOCIEES

  摘要：

  现在已经发现，某些新型的N-(取代芳基)-4(二取代甲基)哌啶和吡啶衍生物具有意想不到的杀虫活性。这些化合物由公式(I)表示：其中m、n、q、r和s分别独立地从0或1中选择；p为0、1、2或3；A为C或CH；B、D、E、R、R1、R2、R3、R4、R5、R6、R7和R8在此处均有完整描述。此外，还披露了包含公式I中至少一种化合物的杀虫有效量的组合物，以及可选地含有至少一种第二化合物的有效量，其中至少一种杀虫兼容载体；以及控制昆虫的方法，包括将上述组合物应用于昆虫存在或预计存在的地点。

  公开号：

  WO2004060371A1

文献信息

• [EN] N-(SUBSTITUTED ARYLMETHYL)-4-(DISUBSTITUTED METHYL) PIPERIDINES AND PYRIDINES<br/>[FR] N-(ARYLMETHYL SUBSTITUE)-4-(METHYL DISUBSTITUE) PIPERIDINES ET PYRIDINES ASSOCIEES
  申请人：FMC CORP

  公开号：WO2004060371A1

  公开（公告）日：2004-07-22

  It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected fronn 0 or 1 ; and p is 0, 1, 2, or 3; A is C or CH; and B, D, E, R, R1, R2, R3, R4, R5, R6, R7 and R8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  现在已经发现，某些新型的N-(取代芳基)-4(二取代甲基)哌啶和吡啶衍生物具有意想不到的杀虫活性。这些化合物由公式(I)表示：其中m、n、q、r和s分别独立地从0或1中选择；p为0、1、2或3；A为C或CH；B、D、E、R、R1、R2、R3、R4、R5、R6、R7和R8在此处均有完整描述。此外，还披露了包含公式I中至少一种化合物的杀虫有效量的组合物，以及可选地含有至少一种第二化合物的有效量，其中至少一种杀虫兼容载体；以及控制昆虫的方法，包括将上述组合物应用于昆虫存在或预计存在的地点。
• N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines
  申请人：Ding Ping

  公开号：US20060135504A1

  公开（公告）日：2006-06-22

  It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected from 0 or 1; and p is 0, 1, 2, or 3; A is C or CH; and B, D, E, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  现已发现某些新型N-(取代芳基)-4(二取代甲基)哌啶和吡啶衍生物具有出乎意料的杀虫活性。这些化合物由式(I)表示：其中m、n、q、r和s独立地选自0或1；p为0、1、2或3；A为C或CH；B、D、E、R、R1、R2、R3、R4、R5、R6、R7和R8在此完整描述。此外，还公开了包含式(I)中至少一种化合物的杀虫有效量和可选的第二种化合物的有效量，以及至少一种杀虫兼容载体的组合物；以及控制昆虫的方法，包括将所述组合物应用于昆虫存在或预计存在的地点。
• N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines
  申请人：Ding Ping

  公开号：US20060166962A1

  公开（公告）日：2006-07-27

  It has now been found that certain novel N-(substituted aryl)-4-(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): wherein m, n, q, r, and s are independently selected from 0 or 1; and p is 0, 1, 2, or 3; A is CH or N; and B, D, E, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  现在已经发现某些新型N-（取代芳基）-4-（二取代甲基）哌啶和吡啶衍生物具有意外的杀虫活性。这些化合物由公式（I）表示：其中m、n、q、r和s独立地选自0或1；p为0、1、2或3；A为CH或N；B、D、E、R、R1、R2、R3、R4、R5、R6、R7和R8在此完全描述。此外，还披露了包含公式I中至少一种化合物的杀虫有效量的组合物，以及可选地，至少一种第二化合物的有效量，具有至少一种杀虫兼容载体；以及用于控制昆虫的方法，包括将所述组合物施用到昆虫存在或预计存在的地点。
• N-Substituted Azacycles
  申请人：Theodoridis George

  公开号：US20090215821A1

  公开（公告）日：2009-08-27

  N-substituted azacycle derivative compounds represented by formula (I): wherein m, q, r, t and u are independently selected from 0 or 1; and p is 0, 1, 2, or 3; and A, B, D, X, Y, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 are fully described herein. The compounds being particularly useful in compositions comprising an insecticidally effective amount of at least one compound of formula I, and an insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  式（I）所代表的N-取代的杂环衍生物化合物：其中m、q、r、t和u独立地选择0或1；p为0、1、2或3；A、B、D、X、Y、R、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11在此完全描述。该化合物在包含式I至少一种化合物的杀虫有效量和杀虫相容载体的组合物中特别有用；以及控制昆虫的方法，包括将所述组合物应用于昆虫存在或预计存在的场所。
• N-substituted azacycles
  申请人：FMC Corporation

  公开号：US08119563B2

  公开（公告）日：2012-02-21

  N-substituted azacycle derivative compounds represented by formula (I): wherein m, q, r, t and u are independently selected from 0 or 1; and p is 0, 1, 2, or 3; and A, B, D, X, Y, R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are fully described herein. The compounds being particularly useful in compositions comprising an insecticidally effective amount of at least one compound of formula I, and an insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  公式（I）所代表的N取代的杂环衍生物化合物： 其中m，q，r，t和u独立地选择0或1；p为0、1、2或3；A、B、D、X、Y、R、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11在此完全描述。本发明还公开了包含公式（I）中至少一种化合物的杀虫有效量以及杀虫剂相容载体的组合物，这些化合物在控制昆虫的方法中应用于昆虫存在或预计存在的场所。