Bis-<4-(pyridyloxy-(3))-phenyl>-ether | 112325-50-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Bis-<4-(pyridyloxy-(3))-phenyl>-ether
• 英文别名: 3-[4-(4-Pyridin-3-yloxyphenoxy)phenoxy]pyridine
• CAS: 112325-50-5
• 化学式: C₂₂H₁₆N₂O₃
• 分子量: 356.381
• InChiKey: RCDSZNLZMZOBFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Bis-<4-(pyridyloxy-(3))-phenyl>-ether 、 1-溴代庚烷 反应 24.0h， 以87%的产率得到
  参考文献：
  名称：

  Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer

  摘要：

  Novel gemini (tail-head-spacer-head-tail) bis-quaternary ammonium compounds with a 4,4'-oxydiphenol spacer between two pyridinium heads were synthesized and compared with commonly used antiseptics such as benzalkonium chloride and chlorhexidine gluconate. Analogues bearing C8H17, C9H19 and C10H21 aliphatic groups displayed potent broad spectrum in vitro activity against five bacterial strains and two fungi, with minimum inhibtory concentrations relatively independent of the counter ion.

  DOI：

  10.1016/j.mencom.2019.09.015
• 作为产物：
  描述：

  3-羟基吡啶 、 4,4'-二溴二苯醚 在 铜 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以77%的产率得到Bis-<4-(pyridyloxy-(3))-phenyl>-ether
  参考文献：
  名称：

  Synthesis and microbiological properties of novel bis-quaternary ammonium compounds based on 4,4′-oxydiphenol spacer

  摘要：

  Novel gemini (tail-head-spacer-head-tail) bis-quaternary ammonium compounds with a 4,4'-oxydiphenol spacer between two pyridinium heads were synthesized and compared with commonly used antiseptics such as benzalkonium chloride and chlorhexidine gluconate. Analogues bearing C8H17, C9H19 and C10H21 aliphatic groups displayed potent broad spectrum in vitro activity against five bacterial strains and two fungi, with minimum inhibtory concentrations relatively independent of the counter ion.

  DOI：

  10.1016/j.mencom.2019.09.015